Oscillations and translation of a free cylinder in a confined flow

An oscillatory instability has been observed experimentally on an horizontal cylinder free to move and rotate between two parallel vertical walls of distance H; its characteristics differ both from vortex shedding driven oscillations and from those of tethered cylinders in the same geometry. The vertical motion of the cylinder, its rotation about its axis and its transverse motion across the gap have been investigated as a function of its diameter D, its density s, of the mean vertical velocity U of the fluid and of its viscosity. For a blockage ratio D/H above 0.5 and a Reynolds number Re larger then 14, oscillations of the rolling angle of the cylinder about its axis and of its transverse coordinate in the gap are observed together with periodic variations of the vertical velocity. Their frequency f is the same for the sedimentation of the cylinder in a static fluid (U = 0) and for a non-zero mean flow (U 6= 0). The Strouhal number St associated to the oscillation varies as 1/Re with : St.Re = 3 $\pm$ 0.15. The corresponding period 1/f is then independent of U and corresponds to a characteristic viscous diffusion time over a distance ~ D, implying a strong influence of the viscosity. These characteristics differ from those of vortex shedding and tethered cylinders for which St is instead roughly constant with Re and higher than here

Influence of confinement on the oscillations of a free cylinder in a viscous flow

We demonstrate and study experimentally two instabilities of a horizontal free cylinder in a vertical viscous Hele-Shaw flow; we show that they depend critically on the confinement of the flow with a different influence of transverse and lateral confinement characterized respectively by the ratios of the diameter (resp. the length) of the cylinder to the gap (resp. the width) of the cell. The onset of the instabilities depends largely on the transverse confinement: for a parameter between 0.4 and 0.6, one observes transverse horizontal oscillations of the cylinder perpendicular to the walls: their frequency is constant with the lateral and transverse confinements at a given cylinder velocity. This instability is shown to be locally two-dimensional and controlled by the local relative velocity between the cylinder and the fluids: it occurs down to Reynolds numbers based on the cell gap ≃ 15, far below the corresponding 2D vortex shedding thresholds (150−250) for fixed cylinders between parallel planes. Above transverse confinements of the order of 0.55, we observe a fluttering motion with periodic oscillations of the tilt angle of the cylinder from the horizontal and of its horizontal position: their frequency decreases strongly as the lateral confinement increases but is independent of the transverse confinement and the cylinder velocity.Fil: Gianorio, Luciano. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: D'angelo, María Verónica. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cachile, Mario Andres. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hulin, Jean Pierre. Universite Paris Sud; FranciaFil: Auradou, Harold. Universite Paris Sud; Franci

Dispersion enhancement and damping by buoyancy driven flows in 2D networks of capillaries

The influence of a small relative density difference on the displacement of two miscible liquids is studied experimentally in transparent 2D networks of micro channels. Both stable displacements in which the denser fluid enters at the bottom of the cell and displaces the lighter one and unstable displacements in which the lighter fluid is injected at the bottom and displaces the denser one are realized. Except at the lowest mean flow velocity U, the average $C(x,t)$ of the relative concentration satisfies a convection-dispersion equation. The dispersion coefficient is studied as function of the relative magnitude of fluid velocity and of the velocity of buoyancy driven fluid motion. A model is suggested and its applicability to previous results obtained in 3D media is discussed

Muscle activation during gait in children with Duchenne muscular dystrophy

The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity

Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Biomarker-based differential diagnosis of the most common forms of dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim of this study was to develop and interpret a ML algorithm capable of differentiating Alzheimer's dementia, frontotemporal dementia, dementia with Lewy bodies and cognitively normal control subjects based on sociodemographic, clinical, and magnetic resonance imaging (MRI) variables. 506 subjects from 5 databases were included. MRI images were processed with FreeSurfer, LPA, and TRACULA to obtain brain volumes and thicknesses, white matter lesions and diffusion metrics. MRI metrics were used in conjunction with clinical and demographic data to perform differential diagnosis based on a Support Vector Machine model called MUQUBIA (Multimodal Quantification of Brain whIte matter biomArkers). Age, gender, Clinical Dementia Rating (CDR) Dementia Staging Instrument, and 19 imaging features formed the best set of discriminative features. The predictive model performed with an overall Area Under the Curve of 98%, high overall precision (88%), recall (88%), and F1 scores (88%) in the test group, and good Label Ranking Average Precision score (0.95) in a subset of neuropathologically assessed patients. The results of MUQUBIA were explained by the SHapley Additive exPlanations (SHAP) method. The MUQUBIA algorithm successfully classified various dementias with good performance using cost-effective clinical and MRI information, and with independent validation, has the potential to assist physicians in their clinical diagnosis