The substellar population of the young cluster lambda Orionis

By collecting optical and infrared photometry and low resolution spectroscopy, we have identified a large number of low mass stars and brown dwarf candidates belonging to the young cluster (~5 Myr) associated with the binary star lambda Orionis. The lowest mass object found is a M8.5 with an estimated mass of 0.02 Msun (~0.01 Msun for objects without spectroscopic confirmation). For those objects with spectroscopy, the measured strength of the Halpha emission line follows a distribution similar to other clusters with the same age range, with larger equivalent widths for cooler spectral types. Three of the brown dwarfs have Halpha emission equivalent widths of order 100 \AA, suggestive that they may have accretion disks and thus are the substellar equivalent of Classical T Tauri stars. We have derived the Initial Mass Function for the cluster. For the substellar regime, the index of the mass spectrum is alpha=0.60$+-0.06, very similar to other young associations.Comment: Astrophysica Journal, accepted April 2, 200

PRE‐dialysis survey on anaemia management

Background. The PRE‐dialysis survey on anaemia management (PRESAM) was designed to assess the care given to pre‐dialysis patients in the 12 months before haemodialysis or peritoneal dialysis, with emphasis on anaemia management. Methods. For this epidemiological study, a retrospective chart review was conducted for patients who started haemodialysis or peritoneal dialysis between 1 August, 1999 and 6 April, 2000. All adult patients who entered one of the 779 participating centres in 21 European countries, Israel or South Africa were included, except for patients who underwent dialysis only during an acute episode. In addition to demographic characteristics, the study examined the prevalence of anaemia, anaemia management including the use of iron supplementation and epoetin, source of referral to the dialysis centre, comorbidities and major clinical events. Results. A total of 4333 new dialysis patients were included in the survey. At the first visit to the dialysis centre, 68% of the patients had a haemoglobin (Hb) concentration ≤11.0 g/dl; Hb concentration was positively correlated with creatinine clearance rate (r=0.43, P<0.01). Patients who received epoetin had a mean Hb concentration of 8.8 g/dl at the start of epoetin treatment, and 96% of these patients had an Hb concentration ≤11.0 g/dl. Only 26.5% of the patients received epoetin before dialysis. The length of time under the care of a nephrologist was associated with meeting the European Best Practice Guidelines (EBPG) target Hb concentration, as well as receiving epoetin. Conclusions. Few pre‐dialysis patients met the EBPG target for Hb concentration, despite regular nephrology car

Caracteristicas de las epidemias de dengue en la ciudad de Santa Cruz (2003-2007)

Se realizó un análisis retrospectivo de las fichas clínico-epidemiológicas y de los resultados serológicos de los casos de dengue de la ciudad de Santa Cruz de la Sierra, durante el período de enero 2003 a octubre 2007. El objetivo es de analizar la evolución temporal espacial de los casos de dengue entre 2003-2007 y determinar los factores de riesgos de tipo demográficos. Se observó que desde el año 2003 el dengue se instaló en la ciudad de Santa Cruz y circuló cada año durante todo el año, incluso en temperada seca. Del 2003 al 2007 la infección viral sube y la precisión del diagnóstico mejora, el porcentaje de muestras positivas pasa de un 25,5% a un 49,4%. El número de casos notificados y casos confirmados son significativamente más importantes para las mujeres que para los hombres(p-<0,0001) y menos importantes en el grupo etáreo inferior a 10 años. El dengue fue más frecuente en el centro de la ciudad dentro del cuarto anillo y en seis zonas que cada año tienen un número de casos superior al medio de la ciudad. La diferenca de distribución de los casos positivos puede ser consecuencia de una información más baja de los casos, más marcada en la zona periférica. (résumé d'auteur

CyberKnife(® )radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters

BACKGROUND: Tumors of the skull base pose unique challenges to radiosurgical treatment because of their irregular shapes, proximity to critical structures and variable tumor volumes. In this study, we investigate whether acceptable treatment plans with excellent conformity and homogeneity can be generated for complex skull base tumors using the Cyberknife(® )radiosurgical system. METHODS: At Georgetown University Hospital from March 2002 through May 2005, the CyberKnife(® )was used to treat 80 patients with 82 base of skull lesions. Tumors were classified as simple or complex based on their proximity to adjacent critical structures. All planning and treatments were performed by the same radiosurgery team with the goal of minimizing dosage to adjacent critical structures and maximizing target coverage. Treatments were fractionated to allow for safer delivery of radiation to both large tumors and tumors in close proximity to critical structures. RESULTS: The CyberKnife(® )treatment planning system was capable of generating highly conformal and homogeneous plans for complex skull base tumors. The treatment planning parameters did not significantly vary between spherical and non-spherical target volumes. The treatment parameters obtained from the plans of the complex base of skull group, including new conformity index, homogeneity index and percentage tumor coverage, were not significantly different from those of the simple group. CONCLUSION: Our data indicate that CyberKnife(® )treatment plans with excellent homogeneity, conformity and percent target coverage can be obtained for complex skull base tumors. Longer follow-up will be required to determine the safety and efficacy of fractionated treatment of these lesions with this radiosurgical system

Spectral theory for a mathematical model of the weak interaction: The decay of the intermediate vector bosons W+/-, II

We do the spectral analysis of the Hamiltonian for the weak leptonic decay of the gauge bosons W+/-. Using Mourre theory, it is shown that the spectrum between the unique ground state and the first threshold is purely absolutely continuous. Neither sharp neutrino high energy cutoff nor infrared regularization are assumed.Comment: To appear in Ann. Henri Poincar\'

Treatment of malignant tumors of the skull base with multi-session radiosurgery

<p>Abstract</p> <p>Objective</p> <p>Malignant tumors that involve the skull base pose significant challenges to the clinician because of the proximity of critical neurovascular structures and limited effectiveness of surgical resection without major morbidity. The purpose of this study was to evaluate the efficacy and safety of multi-session radiosurgery in patients with malignancies of the skull base.</p> <p>Methods</p> <p>Clinical and radiographic data for 37 patients treated with image-guided, multi-session radiosurgery between January 2002 and December 2007 were reviewed retrospectively. Lesions were classified according to involvement with the bones of the base of the skull and proximity to the cranial nerves.</p> <p>Results</p> <p>Our cohort consisted of 37 patients. Six patients with follow-up periods less than four weeks were eliminated from statistical consideration, thus leaving the data from 31 patients to be analyzed. The median follow-up was 37 weeks. Ten patients (32%) were alive at the end of the follow-up period. At last follow-up, or the time of death from systemic disease, tumor regression or stable local disease was observed in 23 lesions, representing an overall tumor control rate of 74%. For the remainder of lesions, the median time to progression was 24 weeks. The median progression-free survival was 230 weeks. The median overall survival was 39 weeks. In the absence of tumor progression, there were no cranial nerve, brainstem or vascular complications referable specifically to CyberKnife^®radiosurgery.</p> <p>Conclusion</p> <p>Our experience suggests that multi-session radiosurgery for the treatment of malignant skull base tumors is comparable to other radiosurgical techniques in progression-free survival, local tumor control, and adverse effects.</p