7 research outputs found
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- Abdulhakim E
- Abraham P
- Abramov G
- Abu Hassan MR
- Adamson K
- Adawi F
- Adkins K
- Adler A
- Adler A
- Agarwal P
- Ahn KJ
- Akpunonu B
- Albota A
- Albu J
- Alexander K
- Alexandru C
- Alfonsi F
- Alt I
- Alvarisqueta AF
- Alvarsson M
- Alversson M
- Ambos A
- Ambos A
- Ambrosio G
- Ambulkar S
- Anagnostis G
- Anastasi L
- Andersone I
- Arambam P
- Aravind S
- Araz M
- Arciszewska M
- Argoud G
- Arias P
- Armaganijan L
- Armstrong PW
- Armstrong PW
- Aroda V
- Artemiuk E
- Aschner Montoya P
- Aschner P
- Athwal R
- Aziz NA
- Azizad M
- Babenko A
- Badat A
- Badenhoop K
- Bahit M
- Baker J
- Bakiner O
- Balaji V
- Balode A
- Baltramonaitiene K
- Banerji MA
- Barbarash O
- Barros P
- Barsiene L
- Bartkowiak A Jr
- Bashkin A
- Batch B
- Bays H
- Beaven A
- Behn P
- Behnke T
- Beijerbacht H
- Benatar J
- Bender G
- Berdan L
- Bergenstal R
- Bernardez S
- Bernecki G
- Bester F
- Bethel A
- Bethel MA
- Bhargava A
- Bias D
- Binnekamp M
- Birkeland K
- Blach E
- Blagden M
- Blicharski T
- Bobeva R
- Bolster E
- Bondar I
- Borges JL
- Bostandzhieva R
- Botella M
- Botero Lopez R
- Brabec T
- Braun M
- Breedveld R
- Brieger D
- Brito F
- Brychta T
- Buchanan P
- Buganova I
- Bundy C
- Bunster Balocchi LB
- Burgess L
- Busch R
- Buse JB
- Buse JB
- Bushnell C
- Cagide AL
- Calella PR
- Califf RM
- Califf S
- Campbell C
- Canella JP
- Cantero MC
- Carpentier A
- Carroll P
- Cavalot F
- Ceponis J
- Chacra A
- Chadha C
- Chan JC
- Chang M
- Chen JF
- Chen LL
- Cheng C
- Cheung W
- Chiasson JL
- Chizhov P
- Choi KM
- Chou CW
- Christopher J
- Christopher J
- Chuang LM
- Chuang LM
- Chung C
- Cinlikov I
- Cipullo MA
- Civeira Murillo F
- Claudi T
- Clayton T
- Clergeot A
- Cohen A
- Cohen J
- Cole B
- Colman P
- Comlekci A
- Connery L
- Constance C
- Cooper L
- Cooperman M
- Cornel J
- Cornel JH
- Coronel Arroyo JA
- Costa e Forti A
- Couffinhal T
- Courreges JP
- Crenier L
- Crisan C
- Cure CA
- Cushman W
- Cutfield R
- Cypryk K
- Dabrowska M
- DAgostino R
- Dalan R
- Daly M
- Darawsha M
- Darbyshire J
- Davies M
- Davies M
- Davis T
- Dayamani P
- De Jong D
- De Lemos J
- De Looze F
- de Loredo L
- De Meireles M
- de Teresa L
- Dean J
- DeHart D
- Del Cañizo FJ
- Del Vecchio L
- Delibasi T
- Delibasi T
- dEmden M
- Demin A
- Den Hartog F
- Descamps O
- Deshpande M
- Detweiler R
- DeVore A
- Dezső E
- Distiller L
- Distiller L
- Dong J
- Donovan D
- Dora S
- Doran Z
- Dreval A
- Dreval AV
- Dshabrailov J
- Dudás M
- Dugano-Daphnis P
- Dulin M
- Dumas R
- Dumitrescu A
- Dunn F
- Eapen Z
- Eaton C
- Eglite R
- Eizyk E
- Eliaschewitz FG
- Ellis G
- Engel SS
- Engel SS
- Erickson B
- Ershova O
- Escobar Cerda EE
- Eskenazi L
- Estevez R
- Extremera BG
- Fabry J
- Feinglos M
- Felício JS
- Ferariu IE
- Filteau P
- Fonseca V
- Force R
- Forker A
- Fosbol E
- Fouche L
- Fox D
- Frisinghelli A
- Fuchs S
- Fulcher G
- Földesi I
- Fülöp T
- Gabriel J
- Gambardella S
- Garceau C
- Garces Flores EE
- Garcia R
- Garg J
- Garg J
- Garvey T
- Gaudiani L
- Ge J
- Gelersztein ES
- Georgieva M
- Gersamija A
- Gerstein HC
- Gerstman M
- Getaneh A
- Gillblad A
- Gillings S
- Gimeno EJ
- Goff D
- Goff D
- Goldberg A
- Goldman S
- Goldstein BJ
- Gorban de Lapertosa SB
- Gouet D
- Govender P
- Govind U
- Grado CR
- Gratsiansky N
- Gray R
- Green J
- Green J
- Green JB
- Gregory V
- Griz LH
- Groop L
- Guimaraes P
- Guler S
- Guo X
- Gómez Medina AM
- Górny G
- Górska M
- Hairston K
- Halvorsen S
- Halvorsen S
- Hamann A
- Hamilton A
- Han SJ
- Hanefeld M
- Hanefeld M
- Hannan K
- Harman-Boehm I
- Harris R
- Harrison R
- Harvey P
- Hasalova Zapletalova J
- Haught W
- Havelkova J
- Hawes J
- Hayden S
- Hayek T
- Hejnicova K
- Henshaw C
- Hermans W
- Hess P
- Hidalgo H Jr
- Higgins A
- Himpel-Boenninghoff A
- Hirsch B
- Hissa MN
- Ho AY
- Ho LT
- Hola O
- Holman RR
- Holman RR
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- Hornackova M
- Horvathova V
- Horvathova V
- Houchin V
- Hramiak I
- Hramiak I
- Hrdina T
- Hristova D
- Hsieh IC
- Huang BH
- Huang CL
- Huang CN
- Hussein Z
- Huynh T
- Hyland K
- Iliev D
- Ilieva E
- Ismail IS
- Ison R
- Istad H
- Jaap A
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- Jaffe A
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- Jafry B
- Jakuboniene N
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- Jakubowska I
- Jan C
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- Jegere B
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- Kamke W
- Kang HJ
- Kantola I
- Kapsner P
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- Kasperk C
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- Kaufman KD
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- Kaye W
- Keenan J
- Kellnerova I
- Kennedy I
- Kerrane J
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- Ketova G
- Keymeulen B
- Kietselaer B
- Kiiroja K
- Kilvert A
- Kim DM
- Kim IJ
- Kim MH
- Kitowska-Koterla J
- Klyver MI
- Knobler H
- Ko T
- Kociol R
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- Kong AP
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- Kotelnikov M
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- Krahulec B
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- Krebs J
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- Krzyzagorska E
- Kudalkar H
- Kumar A
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- Labroo A
- Lachin JM
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- Lai WT
- Lam YY
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- Lanno R
- Larrazabal Miranda Adel P
- Lasiene J
- Lau EY
- Lauro D
- Lazzarini V
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- Lee IK
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- Leitane I
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- Leiter L
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- Lembo G
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- Leotta S
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- Levinger A
- Levinson L
- Lewis S
- Li QM
- Lillestol M
- Lindsay R
- Litchfield J
- Liubenova L
- Lo PH
- Lokhnygina Y
- Lopes R
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- Luedemann J
- Lunt H
- Lupusoru DA
- Luttrell L
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- Madu I
- Maffei LE
- Mahaffey K
- Mahendran KA
- Maldonado N
- Manchanda M
- Manning P
- Marre M
- Martin-Hidalgo A
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- Mathieu C
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- McFarron D
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- McGuire DK
- McGuire DK
- McKnight J
- McMurray JJ
- McNeill R
- Mehta R
- Melloni C
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- Mikulkova I
- Miller D
- Millward B
- Milton J
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- Misinkova I
- Misra A
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- Mohamed M
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- Mohan V
- Molina DI
- Mondillo S
- Morales Alvarado JM
- Morales C
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- Morugova T
- Moses R
- Mosseri M
- Moulin P
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- Nikitov Z
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- Oerter EM
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- Ohlsson-Önerud Å
- Olivares Cañon CM
- Oparil S
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- Osei K
- Ossum Gronert J
- Ott P
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- Oviedo AI
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- Panarotto D
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- Pantlikova C
- Papademetriou V
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- Park Y
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- Paschen B
- Past M
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- Pasternak D
- Patel C
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- Pei D
- Pekarskiy S
- Pencina MJ
- Pentela-Nowicka J
- Perez Amador GA
- Perhonen M
- Pesarchick J
- Peterson ED
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- Petr M
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- Potthoff Cárdenas SH
- Prather K
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- Proietto J
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- Punthakee Z
- Purewal T
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- Raisinghani A
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- Ramanathan GR
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- Ravikumar C
- Rechkova E
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- Reddy NK
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- Rees P
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- Rendell M
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- Rheeder P
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- Robitaille Y
- Rodbard H
- Rodbard HW
- Rodriguez Venegas ME
- Roe M
- Rohlf J
- Rojas Lingan G
- Ronner E
- Rorick T
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- Roseman H
- Rovira A
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- Saavedra Gajardo VA
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- Sadler L
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- Sathyapalan T
- Saunders K
- Sawicki A
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- Scheen A
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- Suryaprakash G
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- Sweeney ME
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- Teterovska D
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- Tranche S
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- Truffa A
- Tsang CC
- Tsao J
- Tsur A
- Turcinek R
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- Turova E
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- Urina Triana MA
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- Van der Heijden R
- Van Der Merwe A
- Van Gaal L
- Van Hessen M
- van Kempen W
- Van Zyl L
- Varanauskiene E
- Vejvodova J
- Velichka D
- Velickiene D
- Veresiu IA
- Veresiu IA
- Vico ML
- Vides H
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- Viljoen M
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- Viswanath D
- Vizel S
- Vo A
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- Vélez Pelaez S
- Wainstein J
- Wainstein J
- Waites J
- Waitman JN
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- Weber Silva DM
- Weintraub H
- Weisnagel S
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- Westerberg Maldonado BH
- White H
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- Wilding J
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- Wolfley A
- Woo V
- Wood M
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- Wurziger J
- Wysham C
- Yakov A
- Yale JF
- Yang T
- Yang WY
- Yared K
- Yeung VT
- Yilmaz M
- Yoo SJ
- Yupanqui Lozno H
- Zachoval R
- Zadionchenko V
- Zak R
- Zavaroni DZ
- Zheng SX
- Ziegler O
- Zimanova J
- Zimmerman R
- Zinman B
- Śmiałowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG
- Author
- A Yamauchi
- AH Schinkel
- ALHJ Aarnoudse
- B F McBride
- B Houltz
- BA Schoonderwoerd
- C Kimchi-Sarfaty
- C Marzolini
- C Napolitano
- D Li
- D M Roden
- D Tishler
- DH Kim
- DM Roden
- DM Roden
- E Jazwinska-Tarnawska
- EL Woodahl
- H Kusuhara
- H Potschka
- JS Mitcheson
- JW Sohn
- KA Kim
- KE Lasser
- L Elens
- LMS Chan
- M Grube
- M Niemi
- M Zhou
- N Bozina
- OP Hamill
- P Yang
- R Clinckers
- RB Kim
- RH Ho
- RR Makkar
- S Rajamani
- SG Priori
- SW Yeola
- T Illmer
- T Seo
- T Yang
- T Yang
- TD Gbadebo
- TJ Cha
- W Haverkamp
- W Shimizu
- Y Kurata
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- \u15amia\u142owski A.
- Abdulhakim E.
- Abraham P.
- Abramov G.
- Abu Hassan M.
- Adamson K.
- Adawi F.
- Adkins K.
- Adler A.
- Adler A.
- Agarwal P.
- Ahn K.
- Akpunonu B.
- Albota A.
- Albu J.
- Alexander K.
- Alexandru C.
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- Alvarisqueta A.
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- Del Ca\uf1izo F.
- Del Vecchio L.
- Delibasi T.
- Delibasi T.
- Demden M.
- Demin A.
- Den Hartog F.
- Descamps O.
- Deshpande M.
- Detweiler R.
- Devore A.
- Dezs\u151 E.
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- Distiller L.
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- Ziegler O.
- Zimanova J.
- Zimmerman R.
- Zinman B.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND
Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin,
a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2
diabetes and cardiovascular disease.
METHODS
In this randomized, double-blind study, we assigned 14,671 patients to add either
sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic
therapy was encouraged as required, aimed at reaching individually appropriate
glycemic targets in all patients. To determine whether sitagliptin was noninferior
to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The
primary cardiovascular outcome was a composite of cardiovascular death, nonfatal
myocardial infarction, nonfatal stroke, or hospitalization for unstable angina.
RESULTS
During a median follow-up of 3.0 years, there was a small difference in glycated
hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo,
120.29 percentage points; 95% confidence interval [CI], 120.32 to 120.27). Overall,
the primary outcome occurred in 839 patients in the sitagliptin group (11.4%;
4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per
100 person-years). Sitagliptin was noninferior to placebo for the primary composite
cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001).
Rates of hospitalization for heart failure did not differ between the two groups
(hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P=0.98). There were no significant
between-group differences in rates of acute pancreatitis (P=0.07) or pancreatic
cancer (P=0.32).
CONCLUSIONS
Among patients with type 2 diabetes and established cardiovascular disease, adding
sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular
events, hospitalization for heart failure, or other adverse events.
(Funded by Merck Sharp & Dohme; TECOS ClinicalTrials.gov number, NCT00790205.
Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure.
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- Zhao R P
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- Zhilyaev E
- Zilahi Z
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- Zuraw B
- Zámolyi K
- Édes I
- Šuch S
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 06/01/2015
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- Araújo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
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- Atar D
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- Atkinson C
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- Augusto Alves da Costa F
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- Christian T. Ruff
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- Zheng ZQ
- Zhou SX
- Zhukova N
- Zhurba S
- Zidkova E
- Zidkova E
- Ziegler K
- Zielinski M
- Zienciuk-Krajka A
- Zimmermann EB
- Zimmermann S
- Zoghi M
- Zoghi M
- Zondag M
- Zotova I
- Zubeeva G
- Zyatenkova E
- Åkerberg A
- Östberg S
- Ŝpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
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- Publication venue
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