Sensitivity of Indian summer monsoon simulation to physical parameterization schemes in the WRF model

A set of 17 experiments, using various combinations of physical parameterization schemes in the Weather Research and Forecasting (WRF) model, were carried out to choose a combination suitable for simulating the Indian summer monsoon. The model experiments, forced with the ERA-Interim reanalysis data, were at 30 km horizontal resolution. The WRF model experiments were initialized on 1 May of each year and integrated until 30 September to cover the entire monsoon season for the years 1982 to 2013. The results indicate that the simulated Indian summer monsoon precipitation and 2 m air temperature are sensitive to the physical parameterization schemes in the WRF model and that choosing the correct combination of physical parameterization schemes is essential for simulating the Indian summer monsoon realistically. Our analysis shows that a model setup with the Kain-Fritsch cumulus scheme, a radiation package with the Dudhia shortwave and Rapid Radiative Transfer Model longwave schemes, the Yonsei State University planetary boundary layer scheme, the WRF Single-Moment 3-class microphysics scheme, the revised MM5 Monin-Obukhov surface layer scheme, and the Unified Noah land surface model is suitable for simulating the precipitation realistically. The model setup with a combination of these physical parameterization schemes was found to have smaller biases and root mean square errors in the simulated precipitation, along with a realistic simulation of intraseasonal and interannual variability of precipitation. The results of this study will be useful to researchers and forecasters using the WRF model to improve the Indian summer monsoon simulations/forecasts over the Indian region

Wealth Mobility in America: A View from the National Longitudinal Survey

We depict and analyze wealth mobility in a national sample of nearly 4,000 households interviewed by the National Longitudinal Survey over a ten year period from the mid 1960s to the mid 1970s. A transition matrix, the Shorrocks measure, average decile position for various subgroups, and wealth in period two compared with wealth in period one are used to describe patterns of wealth mobility. These results and regression models of change in percentile position, of persistence in the top, of movement into the top, of persistence into the bottom, and of movement into the bottom identify winners and losers. The losers include single people, blacks, and those who experienced marital disruption, while winners were the skilled and more educated. These findings have implications for the interpretation of cross-sectional measures of inequality, the explanation of long-term trends in wealth mobility, and the consequences of recent trends in the wage structure.

Hexonic derivatives as human GABA-AT inhibitors: A molecular docking approach

Human ?-aminobutyric acid aminotransferase (GABA-AT), a pyridoxal phosphate dependent enzyme is responsible for the degradation of the inhibitory neurotransmitter GABA. Currently, GABA-AT is a potential drug target for epilepsy due to the selective inhibition in brain. In this computational study, we mainly focus on screening of novel lead candidates against GABA-AT using hexonic derivatives. Structure based virtual screening is performed in Vina that screened top hits based on least binding affinity. Further re-docking on hits is performed in AutoDock results in identification of leads with favorable binding energy and hydrogen bond interactions confirmed the effective inhibition. In conclusion, leads 3-aminohex-5-enoic acid and AG-E-60842 can acts as specific leads for GABA-AT and assist in discovery of novel anti-epileptic drugs

Bioremediation of Penicillin-Contaminated Poultry Faecal Waste using Betalactamase-Producing Bacteria

The widespread use of antibiotics in poultry farming has led to the contamination of the environment with antibiotic residues, posing significant risks to human health and contributing to the development of antibiotic resistance. In this study, we aimed to isolate betalactamase-producing bacteria from poultry faecal waste samples obtained from local poultry processing industries in Namakkal, Tamilnadu, India. The potential isolates were further characterized for betalactamase enzyme activity and their ability to degrade penicillin, a commonly used antibiotic in the poultry industry. Twenty poultry faecal waste samples were collected from regular poultry waste dumping sites. Microorganisms were isolated from these samples using the serial dilution and plating method on nutrient agar media. The isolated bacterial colonies were purified to obtain pure cultures for further analysis. The betalactamase-producing isolates were identified using the iodometric tube method, and four out of ten isolates showed positive results for betalactamase activity. These positive isolates were subjected to enzyme assay, and isolate 10 exhibited the highest enzyme activity with a concentration of 43U/ml, followed by isolate 7 with 30.5U/ml of enzyme. The potential betalactamase-producing isolate 10 was selected for its application in the degradation of penicillin in poultry faecal waste. The faecal waste samples were collected from the antibiotic-contaminated area of a poultry farm. After the addition of separated crude enzyme (5ml of 100U), the faecal sample was incubated for 15 days under specific conditions. HPLC analysis revealed a significant degradation of penicillin in the test sample treated with the betalactamase enzyme, with a degradation percentage of 48.6%. The results of this study indicate that betalactamase-producing bacteria can effectively degrade penicillin in poultry faecal waste. This bioremediation approach presents a potential solution to reduce antibiotic pollution in the environment and mitigate the risk of antibiotic resistance. Further research and application of such enzymatic degradation methods could contribute to sustainable and eco-friendly waste management practices in the poultry industry

Exploring the Antimicrobial Potential of Phyllanthus emblica L. (Amla) using Molecular Docking Studies against Shrimp Pathogens

Vibriosis is a major problem in shrimp farm. Farmers indiscriminately use hormones, antibiotics, disinfectants and other chemicals in fish feed and culture water to protect their crops. E. coli and Aeromonas sp were highly predominant isolates. Herbs act as agents in aquaculture to control or reduce pathogen infections. The results of phytochemicals screening of fruit extract of Phyllanthus emblica showed the presence of various phytchemicals. Phyllanthus emblica extract shows anti-bacterial properties against biofilm producing shrimp pathogens. Among the 10 bacterial genera, E. coli and P.aeruginosa were highly suppressed. The extracts exhibited the bacteria growth inhibitory activity in a dose-dependent manner. The compound sitosterol has potent antibiofilm activity was showed by molecular docking, which revealed a significant binding energy and interaction (-8.4 Kcal/mol) between it and key biofilm-forming protein. Diving analysis was done using the chemical compounds found in GCMS analysis

A national study on the prevalence of obesity among 16,127 Malaysians

A population-based cross-sectional study was conducted in all states of Malaysia with the aim to determine the prevalence of obesity among Malaysians aged fifteen years and above and factors associated. A stratified two stage cluster sampling design with proportional allocation was used. Trained interviewers using a standardized protocol obtained the weight and height measurements and other relevant information. Subjects with a body mass index ≥ 30 kg/m2 were labelled as obese. The results show that the overall national prevalence of obesity among Malaysians aged 15 years old and above was 11.7% (95% CI = 11.1 - 12.4%). The prevalence of obesity was significantly higher in females (13.8%) as compared to 9.6% in males (p< 0.0001). Prevalence of obesity was highest amongst the Malays (13.6%) and Indians (13.5%) followed by the indigenous group of "Sarawak Bumiputra" (10.8%) and the Chinese (8.5%). The indigenous group of "Sabah Bumiputra" had the lowest prevalence of 7.3%. These differences are statistically significant (p< 0.0001). Logistic regression analysis results show that there was a significant association between obesity and age, gender, ethnicity urban/rural status and smoking status. The prevalence of obesity amongst those aged ≥ 18 years old has markedly increased by 280% since the last National Health and Morbidity Survey in 1996. Conclusion: The overall prevalence of obesity in Malaysia is very high as compared to 1996. There is an urgent need for a comprehensive integrated population-based intervention program to ameliorate the growing problem of obesity in Malaysians

The Role of Economic Trade-Offs in the Audit Opinion Decision: An Empirical Analysis

We extend existing audit opinion models by incorporating economic tradeoffs that arise in the auditor's qualification (modification) decision. Prior qualification studies (e.g., Dopuch, Holthausen, and Leftwich [1987]; Bell and Tabor [1991]) do not investigate whether the opinion issued is influenced by particular trade-offs facing an auditor. On the one hand, the audit firm faces the risk of losing the client if it issues a qualification, and on the other, failing to qualify exposes the auditor to lawsuits and reputation loss. We model the auditor's qualification decision as a two-stage model. We estimate a bivariate model that breaks down the probability of qualifying into two components: (1) the probability that the client deserves a qualified opinion based on the audit and (2) the probability that the auditor reports a qualified opinion, given the auditor considers that the client deserves such an opinion. We hypothesize that the second-stage decision to qualify or not is influenced by factors such as the auditor's risk of litigation, the type (Big Six or not) of auditor, the extent of outsider ownership, the share of public debt in total debt, the relative importance of the client in the auditor's portfolio, and the future growth rate of the client. Our results indicate that the auditor's litigation risk, the extent of outsider ownership, the relative importance of the client in the auditor's portfolio, and future growth are important factors in the audit opinion decision. Estimated mean and median probabilities indicate significantly higher values of reporting probabilities for qualified as compared to unqualified firms, suggesting that the second stage is an important component of the qualification decision. </jats:p