Cronología y temporalidad de los recintos de fosos prehistóricos: el caso de Marroquíes Bajos (Jaén)

The time spans of the so-called ditched enclosures are key to a better understanding of a type of site characterised by complex palimpsests. Several conclusions can be drawn from the 16 radiocarbon dates obtained from Ditch 4 at Marroquíes Bajos. According to Bayesian modelling, the filling process began in 2510-2310 cal BC at 2 σ and ended in 2115-1795 cal BC at 2 σ, making them the most recent ditched enclosure with depositional activity in Iberia. Comparison with the dating from other sections of Ditch 4 challenges the traditional assumption that radiocarbon samples obtained from deposits at the bottom of the ditch provide the best dates for its construction. The process by which different sections of the same Ditch 4 were filled at different times suggests that its general outline is more the result of an aggregation of segments than of a single build-up.La temporalidad de los denominados recintos de fosos es un aspecto clave para la correcta compresión de un tipo de yacimiento caracterizado por auténticos palimpsestos de complicada secuenciación. La serie de 16 dataciones radiocarbónicas obtenidas en el Foso 4 de Marroquíes Bajos ha permitido establecer varias conclusiones. Según la modelización bayesiana el inicio del proceso de colmatación se sitúa entre el 2510-2310 cal BC a 2 σ y su final entre el 2115-1795 cal BC a 2 σ, convirtiéndose en el más reciente de los recintos de fosos peninsulares. La comparación con las dataciones existentes para otros tramos del Foso 4 invalida la pretensión de fechar la construcción de los fosos a partir de las dataciones obtenidas en los depósitos asociados a su base. Las secuencias temporalmente diferenciadas en la colmatación de diferentes tramos de un mismo foso sugiere que su configuración es más el resultado de agregados de segmentos que construcciones unitarias

Elaboración de un manual de prácticas para su utilización en asignaturas impartidas por el Departamento de Parasitología

Esta propuesta se presenta como segunda fase del proyecto 20-115, desarrollado durante el periodo 2020-2022 (Plan FIDO UGR). Durante dicho proyecto se han digitalizado 1500 imágenes de parásitos que engloban multitud de especies, incluyendo: protozoos, trematodos, cestodos, nematodos y artrópodos, así como 12000 fotografías necesarias para obtener otras tantas imágenes por la técnica del apilado. Con el ingente material producido se ha elaborado un protocolo de prácticas común para ser utilizado por el alumnado que realice sus prácticas en asignaturas impartidas por el Departamento de Parasitología.Vicerrectorado de Calidad, Innovación Docente y Estudios de Grado-Universidad de Granad

Measures of Resting State EEG Rhythms for Clinical Trials in Alzheimer’s Disease:Recommendations of an Expert Panel

The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12Hz) and widespread delta (<4Hz) and theta (4-8Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and "interrelatedness" rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Advancements in dementia research, diagnostics and care in Latin America : highlights from the 2023 Alzheimer's association international conference satellite symposium in Mexico City

While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics and care. In 2023, the Alzheimer’s Association hosted its eighth Satellite Symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm. A wide range of topics were covered, including epidemiology, social determinants, dementia national plans, risk reduction, genetics, biomarkers, biobanks, and advancements in treatments. Large initiatives in the region including intra-country support showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care and implement affordable biomarkers in the region was highlighted