The Role of Lead Toxicity on Eruption Rate of Hypofunctional Incisors in Albino Wistar Rats

OBJECTIVES This objective of this study was to evaluate the role of a heavy metal- lead acetate in the eruption rate of hypo functional incisors in albino Wistar rats. METHODOLOGY An experimental study was done in animal house of Post Graduate Medical Institute, Lahore since March 2019 to March 2020. 34 adult albino Wistar rats were randomly divided into two groups (n=17 for each group) i.e., control and lead acetate group. Right mandibular incisors were selected for this study. Selected incisors were marked 1mm above the level of gingival papillae. The incisors were cut above this mark to make it hypo-functional. The readings were measured by digital Vernier caliper. This was considered as day 0. Incisors length was measured at day 0, 3, 6, 12 and 15 and eruption was calculated. The data was analyzed using SPSS version 22. RESULTS Eruption rate was similar throughout the study except last follow up. At the end of this study eruption of incisors in albino Wistar rats in control was 03.30±0.72mm, in lead 02.43±1.19mm. At day 15, the difference between control and lead group was statistically significant (p-value 0.033). CONCLUSION These results reveal that besides other causes of delayed tooth eruption excessive lead intoxication are also acausative factor of delayed tooth eruption

Ammonium chloride and urea based deep eutectic solvent: toxicological and antioxidant profile

In the present study, the toxicity potential of ammonium chloride and urea-based deep eutectic solvent (DES) was studied. A homogeneous DES solution was obtained by heating at 60°C for 20 minutes. Fourier Transform Infrared Spectroscopy (FTIR) analysis was used to verify the synthesis. The toxicity profiling of ammonium-based DES was performed using in vitro cell lines (fibroblast growth factor) and microbes (fungi, Gram positive and gram negative bacteria) and in vivo model organism (fish). DES was found to the had maximum zone of inhibition against tested bacterial (Staphylococcus aureus) and fungal strains (Candida albicans). Ammonium chloride-urea DES had higher LC50 against Cyprinus carpio. DES was found to have a higher percentage of cell viability at higher concentration along with DPPH scavenging activity of 92%. In conclusion, ammonium chloride-urea based DES had been successfully formed and found less harmful at higher concentrations, thus can be used as promising solvents in the future

Oil and Gas Potentials of Central Asian Republics and Relations with Pakistan

Purpose-The purpose of this paper is to explore the Oil and Gas potential of Central Asian Republics and to look to new opportunities for Pakistan if relations with CARs are more developed. Design/Methodology / Approach- Descriptive and analytical method is used based on secondary data from reports by EIA (U.S Energy Information Administration), B.P Statistical review of world energy June 2013, Academic papers, books and Newspaper articles etc. A mathematical equation and graphic usage is carried out to illustrate the energy resources of CARs and options are considered for Pakistan to develop better ties with Central Asian Republics. Findings-The paper provides the pen picture of energy richness of Central Asia’s its future growth and prosperity which is directly linked with the development of inter-state and intra-state infrastructure like road and rail. This paper also focus on the challenges at international and regional level and role of global powers those are creating hurdles for CARs to develop economic ties with Pakistan and other regional countries. The presence of US and NATO forces in the region and unrest in Afghanistan has also implications for trade. Research Limitations-This article is related to an energy potential map of CARs with special emphasized on oil and natural Gas resources. The factors those are affecting the Pakistan relations with CARs are also discussed but analysis of U.S interests in Central Asia, great game and control over Eurasia, regional conflicts and political instability are not extensively discussed. Originality/Value-This is the original work. The analysis provided in the paper is based on facts and information based on EIA and other secondary sources.&nbsp

China Central Asia Relations and opportunities for Pakistan

To investigate the strategic depth of China Central Asian relations in the changing paradigm of regional and international politics and to analyze the Pakistan relations with Central Asia and to provide options for CARs to grapple the economic advantages of this regional connectivity of Kashgar to Gwadar through Pakistan China Economic Corridor.&nbsp

Management of commode injuries of Achilles tendon: a newly established tertiary care hospital-based study

Background: The Achilles tendon is the largest and strongest tendon in the body, formed by the union of gastrocnemius and soleus. Despite its strength, the Achilles tendon is vulnerable to injury, due to its subcutaneous position and the high tensions placed on it. Common mode of Achilles tendon injury nowadays in India is slipping of the foot in Indian type of commode and is often fraught with complications due to the potential contamination of wound at the time of injury. The purpose of this study was to assess the clinical outcome and complications of open Achilles tendon injury with an Indian type commode.Methods: 30 patients who presented with open Achilles tendon injury between the ages of 10 to 55 years were included. All the patients were treated with emergency debridement, thorough washing and primary repair within 24 hours using Krackow technique.Results: Out of the 30 patients meeting the inclusion criteria, there was 1 case of superficial infection which resolved with antibiotics and serial dressings. Foreign body sensation was present in 3 patients at final follow-up. Hypertrophic scar formation was seen in one patient. There were no cases of re-rupture in our study. Mean ROM at ankle in saggital plane at final follow-up was 66.13 degrees.Conclusions: Commode injury is the most common cause of open Achilles tendon injury in Indian population. The complications can be minimized by early primary repair and should only be undertaken after thorough washing and debridement under proper antibiotic cover to contain the infection

Phenotypic Diversity among Fennel (Foeniculum Vulgare) Germplasm of Pakistan

Fennel is facing continuous challenge with reference to biotic and abiotic stresses that can be solved with the knowledge of available germplasm of fennel in the country or worldwide. Selection of fennel genotype on the basis of research interest can never been accomplished without gene pool. The aim of the present study was to explore the phenotypic diversity among selective fennel accession and identify lines having high yielding potential. In the present study thirty fennel accessions were sown in PGRI, NARC. Irrigation practice was carried out during the growing period. Data was recorded during different growth stages and after harvesting. Nine morphological parameters under study include plant height, number of umbels/plant, umbel diameter, rays produced/umbel, fruits produced/umble, fruit color and fruit shape. Statistical analysis was performed using ANOVA, Tukey Honest Significance Test and Multivariate cluster Analysis using Minitab Software version 20.0. High diversity was observed among the quantitative traits of thirty accessions. Qualitative traits of accessions from similar region had considerable resemblance. Fennel germplasm collected from Punjab gives outstanding performance with reference to phenotypic traits. Accessions were identified as potential sources including: 21293 (maximum plant height, Punjab, Jhang, Chiniot), 21209 ( great height, Punjab, Faisalabad), 21737 (short height, Punjab, Layyah, Karore Chak-84) 21699 (maximum number of rays/umbel, Punjab, Pakpattan) and 21722 (maximum number of umbels , Punjab, Narowal, Talwandi Bhandran in short 21722 due to high yield was identified as potential sources to be included in future breeding programs for the improvement of fennel varieties

Non-localizing Fever as Urinary Tract Infection in Children

Introduction: Urinary tract infection (UTI) is one of the commonly diagnosed bacterial infections of childhood. However, fever without a localizing point often remains the diagnostic dilemma and not diagnosing UTI could have devastating result for an otherwise easily manageable entity.Materials and Methods: All febrile children aged 2 months to 10 years without an apparent cause of fever were enrolled and evaluated for possible UTI.Results: A total of 304 children were recruited; 140 were males and 164 females. Of 304 who had fever without any apparent signs, 40 had UTI. The prevalence of UTI was 13.2% in the study group.Conclusions: Urinary tract infection presenting as fever without any focus was present in 13.2% of hospitalized patients favouring urine examination to rule out UTI in all febrile children without definite source of fever.Keywords: Child; E Coli; Fever; Urinary tract infections

Immature Platelet Fraction in Patients with Chronic Liver Disease, A Marker for Evaluating Cirrhotic Changes.

Objective: To evaluate the role of Immature platelet fraction in patients with chronic liver disease, a marker for evaluating cirrhotic changes. Methodology: This case control study was conducted at department of Pathology, Aziz Fatima Medical and Dental College, Faisalabad, over a period of Seven months from June 2020 to January 2021. A total of 126 participants were included in the study consisting of 63 patients with chronic liver disease in group A and 63 participants without any known disease in group B as control. The IPF master program in combination with XE-2100 multiparameter automatic hematology analyzer was used to measure the immature platelet fraction. Ethylene diamine tetraacetic acid was used to collect the blood sample for IPF measurement and was maintained till analysis on room temperature. Ten repeated analyses, immediately and after 24 hours were done for reproducibility of IPF%. Results: The mean age of liver disease patients was 52.35 ± 13.64 years and in control group the mean age was 51.62 ± 11.27 years. There was no significant (p-value > 0.05) difference between both groups based on age and gender. The hemoglobin level and red cell count was found to be significantly (p-value < 0.05) reduced in cases group. While white blood cells count was comparable in both groups. The mean platelet count was significantly (p-value < 0.05) less in cases group (163.5 ± 90.4 vs 233.4 ± 54.5 (x10*3/µl). The mean value of immature platelet fraction (IPF%) was significantly (p-value < 0.05) raised in cases group (5.62 ± 2.92 vs 3.06 ± 1.87). The multivariate discriminant analysis (MDA) score showed a significant (p-value < 0.05) association with chronic hepatis as compared to other liver related diseases. Conclusions: In chronic liver disease patients, there is an inverse relationship between platelet count and IPF% with decreased platelet count and increased IPF%. The proposed MDA function can be used to identify the cirrhotic changes in liver disease patients

N-Cyclo­hexyl­benzamide

The structure of the title compound, C13H17NO, features an anti disposition of the N—H and carbonyl groups. The amide group is twisted with respect to the benzene ring [N–C(=O)–C–C torsion angle = −30.8 (4)°]. In the crystal, C(4) chains propagating in [100] are formed by inter­molecular N–H⋯O hydrogen bonds. Weak C—H⋯π inter­actions link the chains into sheets

Pakistan-US Relations after 9/11: Points of Divergence

The research has explored the nature of US-Pakistan relationship particularly after the major event of 9/11 of 2001 in United States. It has highlighted the major points between Pakistan and the United States that have diverted them from each other in case of gaining their common goals in the region ranging from the containment of terrorism to the assurance of security and democracy. Through describing and analysing the facts and figures, mentioned in the published books, research articles, newspapers and other prevailing and relevant data and literature, the research has attempted to mention drone attacks by America in Pakistan‘s Tribal Areas, US-India strategic partnership, US covert military actions in Pakistan, US do more policy, nuclear proliferation, US‘ pressure tactics, US policy towards the Muslim world and America‘s antiIslamic propaganda as the points of divergence due to which Pakistan and United States are experiencing the lowest ebb of relations. The research is helpful for the students of foreign policy of Pakistan, current affairs and the American Studies. In addition to that, the reader will be able to know about the initiatives taken by the Pakistani and the US leadership that have caused deterioration to the cordial relationship of cold war, of late 1980s and mutual concerns to get rid of terrorism and militancy in the 21st century. The last section of this research paper prepared some of the recommendations which can be followed to restore the lost prestige of Pak – US relations based on the mutual understanding for achieving the common goals and to find a better position in the comity of nation