KELT-4Ab: An inflated Hot Jupiter transiting the bright (V~10) component of a hierarchical triple

We report the discovery of KELT-4Ab, an inflated, transiting Hot Jupiter orbiting the brightest component of a hierarchical triple stellar system. The host star is an F star with T_(eff) = 6206 ± 75 K, log g = 4.108 ± 0.014, [Fe/H] = -0.116_(-0.069)^(+0.065, M_* = 1.201_(-0.061)^(+0.067) M_☉, and R_* = 1.603_(-0.038)^(+0.039) R_☉. The best-fit linear ephemeris is BJD_(TDB); = 2456193.29157 ± 0.00021 + E(2.9895936 ± 0.0000048). With a magnitude of V ~ 10, a planetary radius of 1.699_(-0.045)^(+0.046); R_J, and a mass of 0.902_(-0.059)^(+0.060) M_J, it is the brightest host among the population of inflated Hot Jupiters (R_P > 1.5 R_J), making it a valuable discovery for probing the nature of inflated planets. In addition, its existence within a hierarchical triple and its proximity to Earth (210 pc) provide a unique opportunity for dynamical studies with continued monitoring with high resolution imaging and precision radial velocities. The projected separation between KELT-4A and KELT-4BC is 328 ± 16 AU and the projected separation between KELT-4B and KELT-4C is 10.30 ± 0.74 AU. Assuming face-on, circular orbits, their respective periods would be 3780 ± 290 and 29.4 ± 3.6 years and the astrometric motions relative to the epoch in this work of both the binary stars around each other and of the binary around the primary star would be detectable now and may provide meaningful constraints on the dynamics of the system

Single-cell epigenomic variability reveals functional cancer heterogeneity.

BackgroundCell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly create cancer heterogeneity but is difficult to detect and assess functionally.ResultsWe develop a strategy to bridge the gap between measurement and function in single-cell epigenomics. Using single-cell chromatin accessibility and RNA-seq data in K562 leukemic cells, we identify the cell surface marker CD24 as co-varying with chromatin accessibility changes linked to GATA transcription factors in single cells. Fluorescence-activated cell sorting of CD24 high versus low cells prospectively isolated GATA1 and GATA2 high versus low cells. GATA high versus low cells express differential gene regulatory networks, differential sensitivity to the drug imatinib mesylate, and differential self-renewal capacity. Lineage tracing experiments show that GATA/CD24hi cells have the capability to rapidly reconstitute the heterogeneity within the entire starting population, suggesting that GATA expression levels drive a phenotypically relevant source of epigenomic plasticity.ConclusionSingle-cell chromatin accessibility can guide prospective characterization of cancer heterogeneity. Epigenomic subpopulations in cancer impact drug sensitivity and the clonal dynamics of cancer evolution

Processing of invisible social cues.

AbstractSuccessful interactions between people are dependent on rapid recognition of social cues. We investigated whether head direction – a powerful social signal – is processed in the absence of conscious awareness. We used continuous flash interocular suppression to render stimuli invisible and compared the reaction time for face detection when faces were turned towards the viewer and turned slightly away. We found that faces turned towards the viewer break through suppression faster than faces that are turned away, regardless of eye direction. Our results suggest that detection of a face with attention directed at the viewer occurs even in the absence of awareness of that face. While previous work has demonstrated that stimuli that signal threat are processed without awareness, our data suggest that the social relevance of a face, defined more broadly, is evaluated in the absence of awareness

The impact of minority physician representation on minority patient health

Background: Before the COVID-19 pandemic, the medical profession underwent a physician burnout crisis. Post pandemic, physician burnout transformed into an epidemic that has contributed to the inability of physician supply to meet patient demand in the USA. Recent studies by the American Medical Association predict by 2034, a widespread physician shortage across both primary care and non-primary care specialties (AAMC, 2021). As a result, medical institutions have implemented programs to address this shortage. While this shortage is concerning and needs to be addressed, it isn’t the only shortage at hand. Minorities are deeply underrepresented in the medical field with respect to their proportions in the overall USA population. The ongoing physician shortage further exacerbates the disproportionate number of minority physicians. Furthermore, minority underrepresentation isn’t confined to the profession but is also observed among students in medical schools across the United States. Simultaneously, these same underrepresented minority groups disproportionately experience mortality and disability from disease at higher rates compared to their White counterparts (Smedley, 2001). This study analyzes the inverse relationship between the amount minority physicians present in a community and the prevalence of disease among these same minority populations. It also seeks to understand how representation impacts minority health outcomes. Aim: Involving minority communities in the development and implementation of healthcare policies and programs can lead to better healthcare outcomes for those communities. Methods: A systematic literature review was conducted using PubMed, Scopus, and EBSCOhost databases using keywords [(“MINORITY PHYSICIAN” OR “UNDERREPRESENTED MINORITY PHYSICIANS”)] AND [(“MINORITY PATIENTS” OR “MINORITY PATIENT HEALTH OUTCOMES”) AND (“COMMUNITY-BASED PARTICIPATORY RESEARCH”)] Results: The excess burden of illness in minority populations can be contributed to numerous complex factors, including but not limited to socioeconomic inequality, environmental and occupational exposures, discrimination, health risk factors, and less access to health insurance and healthcare. Practical, actionable strategies to address these disparities should include the engagement of families in leadership roles, provision of comprehensive healthcare, cross-sectoral institutional and community collaborations, and the use of community-based participatory research (CBPR) methods. CBPR has demonstrated promise in enhancing the effectiveness of interventions. However, the challenge remains to understand how and what type of partnerships and participation most effectively enhance the integration of science and practice to eliminate disparities. Discussion: Researchers, community leaders, and healthcare professionals are integral in delivering quality healthcare to minority communities. Researchers must be culturally competent enough to be able to go out into these communities and collect accurate data about these communities. Researchers must find effective strategies and methodologies to gain the trust of the minority community that their research is directly impacting. This can effectively be done by working with local community leaders and community organizations. Local community leaders have the responsibility of voicing the issues and barriers that the community has in accessing quality healthcare. Healthcare professionals have a responsibility to take the research data and work with community leaders to find effective ways to address disparities. In some cases, they may even have to seek funding through government agencies to ensure long-term solutions

An Eccentric Hot Jupiter Orbiting the Subgiant HD 185269

We report the detection of a Jupiter-mass planet in a 6.838 day orbit around the 1.28 solar mass subgiant HD 185269. The eccentricity of HD 185269b (e = 0.30) is unusually large compared to other planets within 0.1 AU of their stars. Photometric observations demonstrate that the star is constant to +/-0.0001 mag on the radial velocity period, strengthening our interpretation of a planetary companion. This planet was detected as part of our radial velocity survey of evolved stars located on the subgiant branch of the H-R diagram--also known as the Hertzsprung Gap. These stars, which have masses between 1.2 and 2.5 solar masses, play an important role in the investigation of the frequency of extrasolar planets as a function of stellar mass.Comment: 18 pages, 4 figures, 3 tables, ApJ in press (scheduled for Dec 2006, v652n2

The economic impact of periprosthetic infection in total hip arthroplasty

© 2020 Canadian Medical Association. All rights reserved. Background: Periprosthetic joint infection (PJI) is the third leading cause of total hip arthroplasty (THA) failure. Although controversial, 2-stage revision remains the gold standard treatment for PJI in most situations. To date, there have been few studies describing the economic impact of PJI in today\u27s health care environment. The purpose of the current study was to obtain an accurate estimate of the institutional cost associated with the management of PJI in THA and to assess the economic burden of PJI compared with primary uncomplicated THA. Methods: We conducted a review of primary THA cases and 2-stage revision THA for PJI at our institution. Patients were matched for age and body mass index. All costs associated with each procedure were recorded. Descriptive statistics were used to summarize the collected data. Mean costs, length of stay, clinic visits and readmission rates associated with the 2 cohorts were compared. Results: Fifty consecutive cases of revision THA were matched with 50 cases of uncomplicated primary THA between 2006 and 2014. Compared with the primary THA cohort, PJI was associated with a significant increase in mean length of hospital stay (26.5 v. 2.0 d, p \u3c 0.001), mean number of clinic visits (9.2 v. 3.8, p \u3c 0.001), number of readmissions (12 v. 1, p \u3c 0.001) and average overall cost (Can$38 107 v. Can$6764, t = 8.3, p \u3c 0.001). Conclusion: Treatment of PJI is a tremendous economic burden. Our data suggest a 5-fold increase in hospital expenditure in the management of PJI compared with primary uncomplicated THA

The Cloud Absorption Radiometer HDF Data User's Guide

The purpose of this document is to describe the Cloud Absorption Radiometer (CAR) Instrument, methods used in the CAR Hierarchical Data Format (HDF) data processing, the structure and format of the CAR HDF data files, and methods for accessing the data. Examples of CAR applications and their results are also presented. The CAR instrument is a multiwavelength scanning radiometer that measures the angular distributions of scattered radiation

An interleaved sampling scheme for the characterization of single qubit dynamics

In this paper, we demonstrate that interleaved sampling techniques can be used to characterize the Hamiltonian of a qubit and its environmental decoherence rate. The technique offers a significant advantage in terms of the number of measurements that are required to characterize a qubit. When compared to the standard Nyquist-Shannon sampling rate, the saving in the total measurement time for the interleaved method is approximately proportional to the ratio of the sample rates.Comment: 9 pages, 4 figure

Prioritized Detection of Personally Familiar Faces

We investigated whether personally familiar faces are preferentially processed in conditions of reduced attentional resources and in the absence of conscious awareness. In the first experiment, we used Rapid Serial Visual Presentation (RSVP) to test the susceptibility of familiar faces and faces of strangers to the attentional blink. In the second experiment, we used continuous flash interocular suppression to render stimuli invisible and measured face detection time for personally familiar faces as compared to faces of strangers. In both experiments we found an advantage for detection of personally familiar faces as compared to faces of strangers. Our data suggest that the identity of faces is processed with reduced attentional resources and even in the absence of awareness. Our results show that this facilitated processing of familiar faces cannot be attributed to detection of low-level visual features and that a learned unique configuration of facial features can influence preconscious perceptual processing