Comparative Life Cycle Assessment of Direct and Indirect Solar Water Disinfection Processes in Developing Countries

In July 2010, the UN General Assembly recognized the universal human right to sufficient water for health and sanitation (UN…, 2010). The reliable disinfection of this water plays a critical role in public health (Carter and Miller, 2005), and this study investigates the use of four ultraviolet (UV) disinfection methods for use in international development and disaster relief. The study focuses on the life cycle impacts of four direct and indirect solar ultraviolet disinfection systems. Direct solar disinfection refers to exposure of water to solar radiation, while indirect solar disinfection collects solar energy and uses this to power a UV lamp disinfection reactor. These four systems were compared to chlorine disinfection and automobile distribution as baseline methods. Existing literature was used to define a life cycle functional unit for each system, which quantified the material use, infrastructure required, and life cycle of the components of each system. The impact of each system was then defined in the Life Cycle Analysis software SimaPro. Analyses compared the use of each technology at “community, school, small group, and family” scales. Due to the significant impact that end-of-use of a system can have on rural communities, an end-of-life analysis was conducted in addition to the quantitative life cycle analysis. Life cycle analysis shows that both direct and indirect UV disinfection methods vary dramatically over several categories of impact assessment. End of life analysis and this variation highlight the extremely complicated process of designing the appropriate disinfection system for use in developing countries

The impact of clinical data on the evaluation of tibial fracture healing

<p>Abstract</p> <p>Background</p> <p>Radiographic healing is a common outcome measure in orthopedic trials and adjudication by outcome assessors is often conducted on the basis of plain films alone. The degree to which this process reflects clinical practice, in which both plain films and clinical notes are available, is uncertain. We explored the effect of adding clinical notes to radiographs in the adjudication process of a feasibility trial of tibial shaft fractures.</p> <p>Methods</p> <p>Radiographic and clinical data from a multicenter randomized controlled trial of 51 patients with operatively treated tibial fractures formed the basis of the study data. At the completion of the trial, serial radiographs (anteroposterior and lateral) were independently evaluated for progression of fracture healing, defined as bridging of at least 3 of 4 cortices, by an adjudication committee comprised of 3 blinded orthopaedic trauma surgeons. Immediately after determination of radiographic time to healing, each surgeon was provided with clinical notes associated with each radiographic follow up visit and asked to re-visit their initial impression. Consensus was achieved for both adjudications. We calculated the percentage of time to healing consensus decisions that changed after evaluation of clinical notes. We further examined the contents of clinical notes and their relative influence on the committee's decisions.</p> <p>Results</p> <p>47 of 51 patients were determined to have healed radiographically during the trial follow-up period, and consideration of clinical notes resulted in a change of 40% (19 of 47) of time to healing consensus decisions; however, revised decisions were equally likely to support an earlier or a later time to healing. Clinical notes that resulted in a change to either a 'healed' or a 'not healed' decision contained significantly more comments of either pain resolution or deterioration, respectively, resumption of or failure to resume weightbearing, or either return or no return to work/pre-injury activities (p < 0.001).</p> <p>Conclusions</p> <p>The addition of clinical notes to the adjudication of radiographic fracture healing changed the outcome decision in a substantial number of cases. Orthopedic trialists should consider the addition of clinical notes to adjudication material in studies of fracture healing in order to enhance the generalizability of their results.</p> <p>Trial Registration</p> <p>The TRUST trial was registered [ID <a href="http://www.clinicaltrials.gov/ct2/show/NCT00667849">NCT00667849</a>] at <url>http://clinicaltrials.gov/ct2/show/NCT00667849</url></p

Water Supply in Developing Countries: Student Experiences in the Dominican Republic

In 2010, the United Nations established access to safe drinking water as a basic human right; however, many areas around the globe still lack access. The interdisciplinary service-learning course “Water Supply in Developing Countries” was established at Purdue in 2012 to address the complex issue of water insecurity around the world. Over the past five years, the course has produced teams involving students from nursing, engineering, agricultural economics, biology, and food science working together to develop sustainable, community-scale drinking water treatment systems. In partnership with Aqua Clara International, the student team in 2017 established a drinking water treatment system at the Ana Julia Diaz Luna primary school in the rural community of Las Cañas, Dominican Republic. In addition to the focus on a physical water system, they also collaborated with local educators to design a water, sanitation, and hygiene (WASH) education program. Students guided development of sustainable economic strategies to utilize the system for generation of revenue to reinvest in maintenance and improvements. The observations and lessons learned from the completed stages of this project have been applied to improve the effectiveness and efficiency of subsequent interventions

Medical students’ challenges and suggestions regarding research training: a synthesis of comments from a cross-sectional survey

Background: We previously reported on a cross-sectional study of students from the Michael G. DeGroote School of Medicine at McMaster University that found most respondents wanted more opportunities to participate in research. Students provided additional comments that we synthesized to enrich the findings of our quantitative analysis.&nbsp;&nbsp; Methods: From our previously administered 13-item, online questionnaire, run across three campuses in Ontario, Canada, 498 of 618 medical students completed our survey and 360 (72%) provided optional written comments, which we synthesized using thematic analysis in this current study.&nbsp; Results: Major themes that emerged were: (1) Active student participation to identify research opportunities and interested mentors are needed; (2) Types of research involvement; (3) Uncertainty whether research training translates into useable skills; (4) Desire for a formalized research curriculum and centralization of research opportunities across campuses.&nbsp; Conclusion: Programs should stress to interested students the importance of actively looking for research opportunities and consider both large and small-group educational sessions

Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials

Objective To determine the efficacy of low intensity pulsed ultrasonography for healing of fractures

Predictors of in-hospital mortality among patients with pulmonary tuberculosis : a systematic review and meta-analysis

Background: There is uncertainty regarding which factors are associated with in-hospital mortality among patients with pulmonary TB (PTB). The aim of this systematic review and meta-analysis is to identify predictors of in-hospital mortality among patients with PTB. Methods: We searched MEDLINE, EMBASE, and Global Health, for cohort and case-control studies that reported risk factors for inhospital mortality in PTB. We pooled all factors that were assessed for an association, and presented relative associations as pooled odds ratios (ORs). Results: We identified 2,969 records, of which we retrieved 51 in full text; 11 cohort studies that evaluated 5,468 patients proved eligible. Moderate quality evidence suggested an association with co-morbid malignancy and in-hospital mortality (OR 1.85; 95% CI 1.01–3.40). Low quality evidence showed no association with positive sputum smear (OR 0.99; 95% CI 0.40–2.48), or male sex (OR 1.09, 95% CI 0.84–1.41), and very low quality evidence showed no association with diabetes mellitus (OR 1.31, 95% IC 0.38–4.46), and previous TB infection (OR 2.66, 95% CI 0.48–14.87). Conclusion: Co-morbid malignancy was associated with increased risk of in-hospital death among pulmonary TB patients. There is insufficient evidence to confirm positive sputum smear, male sex, diabetes mellitus, and previous TB infection as predictors of in-hospital mortality in TB patients

Predicting Time on Prolonged Benefits for Injured Workers with Acute Back Pain

Introduction Some workers with work-related compensated back pain (BP) experience a troubling course of disability. Factors associated with delayed recovery among workers with work-related compensated BP were explored. Methods This is a cohort study of workers with compensated BP in 2005 in Ontario, Canada. Follow up was 2æyears. Data was collected from employers, employees and health-care providers by the Workplace Safety and Insurance Board (WSIB). Exclusion criteria were: (1) no-lost-time claims, (2) \u3e30ædays between injury and claim filing, (3) 65æyears. Using proportional hazard models, we examined the prognostic value of information collected in the first 4æweeks after injury. Outcome measures were time on benefits during the first episode and time until recurrence after the first episode. Results Of 6,657 workers, 1,442 were still on full benefits after 4æweeks. Our final model containing age, physical demands, opioid prescription, union membership, availability of a return-to-work program, employer doubt about work-relatedness of injury, worker?s recovery expectations, participation in a rehabilitation program and communication of functional ability was able to identify prolonged claims to a fair degree [area under the curve (AUC)æ=æ.79, 95æ% confidence interval (CI) .74?.84]. A model containing age, sex, physical demands, opioid prescription and communication of functional ability was less successful at predicting time until recurrence (AUCæ=æ.61, 95æ% CI .57, .65). Conclusions Factors contained in information currently collected by the WSIB during the first 4æweeks on benefits can predict prolonged claims, but not recurrent claims. Electronic supplementary material The online version of this article (doi:10.1007/s10926-014-9534-5) contains supplementary material, which is available to authorized users

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus : systematic review and meta-analysis of randomised and non-randomised studies

Objective To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus. Design Systematic review and meta-analysis. Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov. Eligibility criteria Randomised and non-randomised controlled clinical trials, prospective or retrospective cohort studies, and case-control studies of treatment with glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors in adults with type 2 diabetes mellitus compared with placebo, lifestyle modification, or active anti-diabetic drugs. Data collection and analysis Pairs of trained reviewers independently screened for eligible studies, assessed risk of bias, and extracted data. A modified Cochrane tool for randomised controlled trials and a modified version of the Newcastle-Ottawa scale for observational studies were used to assess bias. We pooled data from randomised controlled trials using Peto odds ratios, and conducted four prespecified subgroup analyses and a post hoc subgroup analysis. Because of variation in outcome measures and forms of data, we describe the results of observational studies without a pooled analysis. Results 60 studies (n=353 639), consisting of 55 randomised controlled trials (n=33 350) and five observational studies (three retrospective cohort studies, and two case-control studies; n=320 289) were included. Pooled estimates of 55 randomised controlled trials (at low or moderate risk of bias involving 37 pancreatitis events, raw event rate 0.11%) did not suggest an increased risk of pancreatitis with incretins versus control (odds ratio 1.11, 95% confidence interval 0.57 to 2.17). Estimates by type of incretin suggested similar results (1.05 (0.37 to 2.94) for GLP-1 agonists v control; 1.06 (0.46 to 2.45) for DPP-4 inhibitors v control). Analyses according to the type of control, mode, duration of treatment, and individual incretin agents suggested no differential effect by subgroups, and sensitivity analyses by alternative statistical modelling and effect measures did not show important differences in effect estimates. Three retrospective cohort studies (moderate to high risk of bias, involving 1466 pancreatitis events, raw event rate 0.47%) also did not suggest an increased risk of pancreatitis associated with either exenatide (adjusted odds ratios 0.93 (0.63 to 1.36) in one study and 0.9 (0.6 to 1.5) in another) or sitagliptin (adjusted hazard ratio 1.0, 0.7 to 1.3); a case-control study at moderate risk of bias (1003 cases, 4012 controls) also suggested no significant association (adjusted odds ratio 0.98, 0.69 to 1.38). Another case-control study (1269 cases, 1269 controls) at moderate risk of bias, however, suggested that the use of either exenatide or sitagliptin was associated with significantly increased odds of acute pancreatitis (use within two years v no use, adjusted odds ratio 2.07, 1.36 to 3.13). Conclusions The available evidence suggests that the incidence of pancreatitis among patients using incretins is low and that the drugs do not increase the risk of pancreatitis. Current evidence, however, is not definitive, and more carefully designed and conducted observational studies are warranted to definitively establish the extent, if any, of increased risk