Kejahatan Phising dalam Dunia Cyber Crime dan Sistem Hukum di Indonesia

Cyber Crime merupakan kejahatan yang timbul karena dampak negatif pemanfaatan teknologi internet. Cyber Crime ini bukan hanya kejahatan terhadap komputer tetapi juga kejahatan terhadap sistem jaringan komputer dan pengguna. Pelaku Cyber Crime saat ini melakukan kejahatan tersebut bukan hanya karna mempraktikkan keahlian yang dimiliki tetapi juga karena motif lain seperti uang, dendam, politik, iseng, dan sebagainya. Salah satu bentuk kejahatan teknologi ialah kejahatan phising (pengelabuan) terhadap situs online seperti website. Metode pengumpulan data dilakukan dengan mengumpulkan dokumen dari jurnal, artikel, makalah, dan lain-lain. Oleh karena itu, hasil penelitian penulis diharapkan dapat memberikan kontribusi minimal bagi mereka yang ingin mendalami permasalahan Cyber Law di Indonesia. Latar belakang terjadinya kejahatan di dunia maya yaitu saling terhubungnya antara jaringan yang satu dengan yang lain sehingga memudahkan pelaku kejahatan untuk melakukan aksinya. Selain itu, tidak meratanya penyebaran teknologi menjadi salah satu factor terjadinya Cyber Crime

Addressing the major information technology challenges of electronic textbooks

Electronic textbooks (e-Textbooks) are digitized forms of textbooks which are envisioned to replace existing paper-based textbooks. After intensive literature review, together with interview results, our study has figured out four major IT-based challenges associated with e-Textbooks in its pursuit to replace the traditional textbooks, namely standardizing format of content, improving service reliability, improving quality and accuracy of content, and improving readability. This paper also provides an extensive review on how these challenges have been approached using existing e-Textbook solutions, such as N-Screen services, cloud computing, open market place, P2P between devices and HTML5. For each solution, we develop a usage scenario in which users apply the aforementioned technologies to interact with e-Textbooks and share contents among themselves. This article aims to provide a strong foundation for further investigations into the development and distribution of e-Textbooks for eventual successful adoption of e-Textbooks in school education

Can an electronic textbooks be part of K-12 education?: Challenges, technological solutions and open issues

An electronic textbook (e-Textbook) is a digitized (or electronic) form of textbook, which normally needs an endorsement by the national or state government when it is used in the K-12 education system. E-Textbooks have been envisioned to replace existing paper-based textbooks due to its educational advantages. Hence, it is of paramount importance for the relevant parties (i.e. national and state governments, or school districts) to draw a comprehensive roadmap of technologies necessary for the successful adoption of e-Textbooks nationwide. This paper provides a brief overview of e-Textbooks and subsequently an extensive discussion on challenges associated with e-Textbooks in the pursuit of replacing traditional textbooks with e-Textbooks. This paper further provides an extensive review on how the challenges have been approached using existing e-Textbook technologies, such as multi-touch technology, e-Paper, Web 2.0 and cloud computing. Literature review and interview have been conducted to identify the challenges of e Textbooks implementation in terms of e-Textbook usage levels and the reasons of its refusal. There were 180 students and 20 academic staff participated as a sample for interviews. Eight categories of key challenges were identified. Subsequently, assessment was performed on how the evolving e-Textbook technology has been applied to address the key challenges and problems. This article aims to provide a strong foundation for further investigations in e-Textbooks for successful adoption of e-Textbooks in school education

Commercial leases in the UK regions: business as usual?

PurposeThe purpose of this paper is to analyse the changing nature of commercial leases with specific reference to the landlord and tenant relationship, lease lengths and incentivisation in the post-recessionary UK property market.Design/methodology/approachThe research applies data analysis utilising the Estates Gazette Interactive database coupled with survey analysis conducted across three UK cities to investigate and compare the changing nature of the commercial property leasing market and the landlord and tenant relationship.FindingsThe empirical analysis highlights that recessionary conditions prevalent in the market from the 2007 global crisis has caused a reassessment of lease structures, leading to shorter lease terms and increased use of incentives, as tenants have been empowered to negotiate more flexible leases due to their stronger market position.Originality/valueThis paper builds upon previous research conducted back in 2005, investigating commercial leases in the market up-cycle. The recent volatility in the commercial property sector requires fresh insights and in-depth analysis of lease patterns, length and covenant strength, which is fundamental for investor decision-making. In addition, past research has tended to consider solely landlord or occupier perspectives, whereas this research offers new insight into the landlord–tenant lease negotiation process.</jats:sec

Subtractive hybridization identifies stem cell-associated genes in an acute myeloid leukemia with poor prognosis

Introduction: Current prognostic markers have improved survival prediction, however, it has not advanced treatment strategies. Gene expression profiling may identify biological markers suitable as therapeutic targets. Leukaemia stem cell is associated with adverse outcome, however, its biological characteristics are still being investigated. We observed higher in vitro cell viability in acute myeloid leukaemia (AML) samples with poor prognosis, which may be stem cell related. Objective: The objective of this study was to profile highly expressed genes in an AML sample of poor prognosis/high viability and compare with a sample of good prognosis/low viability. Method: Subtractive hybridization was performed on two AML samples with high blast counts (>80%), a poor prognosis, PP (disease free survival, DFS12 months) sample. The PP sample had higher CD34+ counts (73% vs 46%) and higher cell viability than the GP sample. cDNA libraries were subsequently cloned and sequenced. Results: cDNA subtracted from the PP samples was identified as genes active during fetal/embryonic development (LCOR, CNOT1, ORMDL1), HOX-related genes (HOXA3, PBX3, SF3B1), hematopoiesis (SELL, IL-3RA) and aerobic lycolysis/hypoxia (PGK1, HIGD1A) -associated genes. Majority of GP clones isolated contained genes involved in oxidative phosphorylation, OXPHOS (COXs, ATPs, MTND4 and MTRNR2), protein synthesis (including ribosomal proteins, initiating and elongation factors), chromatin remodeling (H2AFZ, PTMA), cell motility (MALAT1, CALM2, TMSB4X), and mitochondria (HSPA9, MPO) genes. Conclusion: Thus, the PP sample exhibited stem cell-like features while the GP sample showed cells at a high level of cell activity. These genes are potential prognostic markers and targets for therapy

The Effects of Sports Simulation on Motor Competency: Bandura’s Social Cognitive Theory

The constant growth of video games allows concept innovations such as sports simulation, incorporating realism into video games. In line with this, a study suggests that digital sports can be a tool to improve motor skills, to which Bandura\u27s Social Cognitive of Observational Learning (BCST) became the key concept in both. Therefore, the researchers focused on studying the effects of sports simulation in enhancing motor competencies through BCST. In attaining this, the researchers aim to discover the effects of NBA2k22 on the fundamental basketball skills of novice players and identify how Bandura\u27s Theory contributes to the motor learning and competency of an individual through sports simulation games. For the study, the researchers utilized a sequential explanatory design—a quasi-experimental and simple case study design for the quantitative and qualitative portion of the study, respectively. Three individuals were gathered to perform three tests. Namely, the accuracy pass test, speed dribble test, and bounce pass test for both the pre-test and post-test to assess their skill levels for each movement. The subjects underwent a 2-week intervention wherein each individual played two hours of NBA2k22 MyCareer. Afterward, the subjects were put in a semi-structured interview, further assessing their improvement. The findings of the study support the hypothesis that sports simulation video games have an effect on the dribbling and passing skills of novice basketball players

OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia

Spermatocytic seminoma (SS) is a rare testicular neoplasm that occurs predominantly in older men. In this study, we aimed to shed light on the histogenesis of SS by investigating the developmental expression of protein markers that identify distinct subpopulations of human spermatogonia in the normal adult testis. We analysed the expression pattern of OCT2, SSX2-4, and SAGE1 in 36 SS cases and four intratubular SS (ISS) as well as a series of normal testis samples throughout development. We describe for the first time two different types of SS characterized by OCT2 or SSX2-4 immunoexpression. These findings are consistent with the mutually exclusive antigenic profile of these markers during different stages of testicular development and in the normal adult testis. OCT2 was expressed predominantly in Adark spermatogonia, SSX2-4 was present in Apale and B spermatogonia and leptotene spermatocytes, whilst SAGE1 was exclusively present in a subset of post-pubertal germ cells, most likely B spermatogonia. The presence of OCT2 and SSX2-4 in distinct subsets of germ cells implies that these markers represent germ cells at different maturation stages. Analysis of SAGE1 and SSX2-4 in ISS showed spatial differences suggesting ongoing maturation of germ cells during progression of SS tumourigenesis. We conclude that the expression pattern of OCT2, SSX2-4, and SAGE1 supports the origin of SS from spermatogonia and provides new evidence for heterogeneity of this tumour, potentially linked either to the cellular origin of SS or to partial differentiation during tumour progression, including a hitherto unknown OCT2-positive variant of the tumour likely derived from Adark spermatogonia. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd

Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?

We recently provided the first description of a nuclear mechanism used by Protein Kinase C-theta (PKC-θ) to mediate T cell gene expression. In this mode, PKC-θ tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LSD1, and the adaptor molecule 14-3-3ζ at regulatory regions of inducible immune response genes. Moreover, our genome-wide analysis identified many novel PKC-θ target genes and microRNAs implicated in T cell development, differentiation, apoptosis, and proliferation. We have expanded our ChIP-on-chip analysis and have now identified a transcription factor motif containing NF-κB binding sites that may facilitate recruitment of PKC-θ to chromatin at coding genes. Furthermore, NF-κB association with chromatin appears to be a prerequisite for the assembly of the PKC-θ active complex. In contrast, a distinct NF-κB-containing module appears to operate at PKC-θ targeted microRNA genes, and here NF-κB negatively regulates microRNA gene transcription. Our efforts are also focusing on distinguishing between the nuclear and cytoplasmic functions of PKCs to ascertain how these kinases may synergize their roles as both cytoplasmic signaling proteins and their functions on the chromatin template, together enabling rapid induction of eukaryotic genes. We have identified an alternative sequence within PKC-θ that appears to be important for nuclear translocation of this kinase. Understanding the molecular mechanisms used by signal transduction kinases to elicit specific and distinct transcriptional programs in T cells will enable scientists to refine current therapeutic strategies for autoimmune diseases and cancer