6,739 research outputs found

    Dopamine receptors in a songbird brain.

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    Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior. In songbirds, dopamine is released into the striatal song nucleus Area X, and the levels depend on social contexts of undirected and directed singing. This differential release is associated with differential expression of activity-dependent genes, such as egr1 (avian zenk), which in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all avian dopamine receptors: the D1 (D1A, D1B, D1D) and D2 (D2, D3, D4) families. Comparative sequence analyses of predicted proteins revealed expected phylogenetic relationships, in which the D1 family exists as single exon and the D2 family exists as spliced exon genes. In both zebra finch and chicken, the D1A, D1B, and D2 receptors were highly expressed in the striatum, the D1D and D3 throughout the pallium and within the mesopallium, respectively, and the D4 mainly in the cerebellum. Furthermore, within the zebra finch, all receptors, except for D4, showed differential expression in song nuclei relative to the surrounding regions and developmentally regulated expression that decreased for most receptors during the sensory acquisition and sensorimotor phases of song learning. Within Area X, half of the cells expressed both D1A and D2 receptors, and a higher proportion of the D1A-only-containing neurons expressed egr1 during undirected but not during directed singing. Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context-dependent behaviors

    The Stripe 82 1-2 GHz Very Large Array Snapshot Survey: Multiwavelength Counterparts

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    We have combined spectrosopic and photometric data from the Sloan Digital Sky Survey (SDSS) with 1.41.4 GHz radio observations, conducted as part of the Stripe 82 121-2 GHz Snapshot Survey using the Karl G. Jansky Very Large Array (VLA), which covers 100\sim100 sq degrees, to a flux limit of 88 μ\muJy rms. Cross-matching the 1176811\,768 radio source components with optical data via visual inspection results in a final sample of 47954\,795 cross-matched objects, of which 19961\,996 have spectroscopic redshifts and 27992\,799 objects have photometric redshifts. Three previously undiscovered Giant Radio Galaxies (GRGs) were found during the cross-matching process, which would have been missed using automated techniques. For the objects with spectroscopy we separate radio-loud Active Galactic Nuclei (AGN) and star-forming galaxies (SFGs) using three diagnostics and then further divide our radio-loud AGN into the HERG and LERG populations. A control matched sample of HERGs and LERGs, matched on stellar mass, redshift and radio luminosity, reveals that the host galaxies of LERGs are redder and more concentrated than HERGs. By combining with near-infrared data, we demonstrate that LERGs also follow a tight KzK-z relationship. These results imply the LERG population are hosted by population of massive, passively evolving early-type galaxies. We go on to show that HERGs, LERGs, QSOs and star-forming galaxies in our sample all reside in different regions of a WISE colour-colour diagram. This cross-matched sample bridges the gap between previous `wide but shallow' and `deep but narrow' samples and will be useful for a number of future investigations.Comment: 17 pages, 19 figures. Resubmitted to MNRAS after the initial comment

    Characterization of Hypertension Risk Factors at the Committee on Temporary Shelter

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    Introduction: The health of homeless populations is at risk due to a high prevalence of undiagnosed hypertension (HTN) and cardiovascular disease (CVD). The interaction of housing and socioeconomic status with the risk factors for HTN and CVD remains unclear. Prevention of HTN through a healthy diet, exercise, adequate sleep, and avoidance of tobacco has been well described, but financial limitations and competing priorities for shelter and food make blood pressure (BP) control difficult for this population. By characterizing the risk factors and awareness of hypertension within the homeless population at the Committee on Temporary Shelter Daystation (COTS) in Burlington, Vermont, we may be able to identify promising avenues for therapeutic intervention.https://scholarworks.uvm.edu/comphp_gallery/1226/thumbnail.jp

    A kinematical approach to gravitational lensing using new formulae for refractive index and acceleration

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    This paper uses the Schwarzschild metric to derive an effective refractive index and acceleration vector that account for relativistic deflection of light rays, in an otherwise classical kinematic framework. The new refractive index and the known path equation are integrated to give accurate results for travel time and deflection angle, respectively. A new formula for coordinate acceleration is derived which describes the path of a massless test particle in the vicinity of a spherically symmetric mass density distribution. A standard ray-shooting technique is used to compare the deflection angle and time delay predicted by this new formula with the previously calculated values, and with standard first order approximations. Finally, the ray shooting method is used in theoretical examples of strong and weak lensing, reproducing known observer-plane caustic patterns for multiple masses.Comment: 11 pages, 7 figures, MNRAS accepte

    Shapes and Shears, Stars and Smears: Optimal Measurements for Weak Lensing

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    We present the theoretical and analytical bases of optimal techniques to measure weak gravitational shear from images of galaxies. We first characterize the geometric space of shears and ellipticity, then use this geometric interpretation to analyse images. The steps of this analysis include: measurement of object shapes on images, combining measurements of a given galaxy on different images, estimating the underlying shear from an ensemble of galaxy shapes, and compensating for the systematic effects of image distortion, bias from PSF asymmetries, and `"dilution" of the signal by the seeing. These methods minimize the ellipticity measurement noise, provide calculable shear uncertainty estimates, and allow removal of systematic contamination by PSF effects to arbitrary precision. Galaxy images and PSFs are decomposed into a family of orthogonal 2d Gaussian-based functions, making the PSF correction and shape measurement relatively straightforward and computationally efficient. We also discuss sources of noise-induced bias in weak lensing measurements and provide a solution for these and previously identified biases.Comment: Version accepted to AJ. Minor fixes, plus a simpler method of shape weighting. Version with full vector figures available via http://www.astro.lsa.umich.edu/users/garyb/PUBLICATIONS

    Weak gravitational lensing with the Square Kilometre Array

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    We investigate the capabilities of various stages of the SKA to perform world-leading weak gravitational lensing surveys. We outline a way forward to develop the tools needed for pursuing weak lensing in the radio band. We identify the key analysis challenges and the key pathfinder experiments that will allow us to address them in the run up to the SKA. We identify and summarize the unique and potentially very powerful aspects of radio weak lensing surveys, facilitated by the SKA, that can solve major challenges in the field of weak lensing. These include the use of polarization and rotational velocity information to control intrinsic alignments, and the new area of weak lensing using intensity mapping experiments. We show how the SKA lensing surveys will both complement and enhance corresponding efforts in the optical wavebands through cross-correlation techniques and by way of extending the reach of weak lensing to high redshift.Comment: 19 pages, 6 figures. Cosmology Chapter, Advancing Astrophysics with the SKA (AASKA14) Conference, Giardini Naxos (Italy), June 9th-13th 201

    Practice-Focused, Constructivist Grounded Theory Methodology In Higher Education Leadership Research

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    A growing body of education research considers practices, however there is less focus on a methodology that enables practical analysis of practices. Use of practice theory is growing, particularly in work and organisational studies, but practice focused studies more frequently address theoretical than methodological agenda. This chapter proposes a practice-focused, constructivist grounded theory methodology as one approach which can address this gap. After first considering the ways in which, separately and in combination, practice-theory and constructivist grounded theory can support higher education leadership and management research, the chapter considers implementation of this methodology by drawing on a study into the practice of authority in higher education leadership. It concludes by considering some implications for the ways in which practices can be understood and the affordances and limitations of this methodology.Peer reviewe
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