14 research outputs found
Reviewing evidence of marine ecosystem change off South Africa
Recent changes have been observed in South African marine ecosystems. The main pressures on these
ecosystems are fishing, climate change, pollution, ocean acidification and mining. The best long-term datasets are
for trends in fishing pressures but there are many gaps, especially for non-commercial species. Fishing pressures
have varied over time, depending on the species being caught. Little information exists for trends in other
anthropogenic pressures. Field observations of environmental variables are limited in time and space. Remotely
sensed satellite data have improved spatial and temporal coverage but the time-series are still too short to
distinguish long-term trends from interannual and decadal variability. There are indications of recent cooling on the
West and South coasts and warming on the East Coast over a period of 20 - 30 years. Oxygen concentrations on the
West Coast have decreased over this period. Observed changes in offshore marine communities include southward
and eastward changes in species distributions, changes in abundance of species, and probable alterations in
foodweb dynamics. Causes of observed changes are difficult to attribute. Full understanding of marine ecosystem
change requires ongoing and effective data collection, management and archiving, and coordination in carrying out
ecosystem research.DHE
Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course
The âisomorphic subtype of diffuse astrocytomaâ was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas. Immunohistochemically, they were GFAP-positive, MAP2-, OLIG2- and CD34-negative, nuclear ATRX-expression was retained and proliferation was low. All 24 cases sequenced were IDH-wildtype. In cluster analyses of DNA methylation data, isomorphic diffuse gliomas formed a group clearly distinct from other glial/glio-neuronal brain tumours and normal hemispheric tissue, most closely related to paediatric MYB/MYBL1-altered diffuse astrocytomas and angiocentric gliomas. Half of the isomorphic diffuse gliomas had copy number alterations of MYBL1 or MYB (13/25, 52%). Gene fusions of MYBL1 or MYB with various gene partners were identified in 11/22 (50%) and were associated with an increased RNA-expression of the respective MYB-family gene. Integrating copy number alterations and available RNA sequencing data, 20/26 (77%) of isomorphic diffuse gliomas demonstrated MYBL1 (54%) or MYB (23%) alterations. Clinically, 89% of patients were seizure-free after surgery and all had a good outcome. In summary, we here define a distinct benign tumour class belonging to the family of MYB/MYBL1-altered gliomas. Isomorphic diffuse glioma occurs both in children and adults, has a concise morphology, frequent MYBL1 and MYB alterations and a specific DNA methylation profile. As an exclusively histological diagnosis may be very challenging and as paediatric MYB/MYBL1-altered diffuse astrocytomas may have the same gene fusions, we consider DNA methylation profiling very helpful for their identification
Spatial patterns in the biology of the chokka squid, Loligo reynaudii on the Agulhas Bank, South Africa
Although migration patterns for various life history stages of the chokka squid (Loligo reynaudii) have been previously presented, there has been limited comparison of spatial variation in biological parameters. Based on data from research surveys; size ranges of juveniles, subadults and adults on the Agulhas Bank were estimated and presented spatially. The bulk of the results appear to largely support the current acceptance of the life cycle with an annual pattern of squid hatching in the east, migrating westwards to offshore feeding grounds on the Central and Western Agulhas Bank and the west coast and subsequent return migration to the eastern inshore areas to spawn. The number of adult animals in deeper water, particularly in autumn in the central study area probably represents squid spawning in deeper waters and over a greater area than is currently targeted by the fishery. The distribution of life history stages and different feeding areas does not rule out the possibility that discrete populations of L. reynaudii with different biological characteristics inhabit the western and eastern regions of the Agulhas Bank. In this hypothesis, some mixing of the populations does occur but generally squid from the western Agulhas Bank may occur in smaller numbers, grow more slowly and mature at a larger size. Spawning occurs on the western portion of the Agulhas Bank, and juveniles grow and mature on the west coast and the central Agulhas Bank. Future research requirements include the elucidation of the age structure of chokka squid both spatially and temporally, and a comparison of the statolith chemistry and genetic characterization between adults from different spawning areas across the Agulhas Bank
A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors
Advances and Perspectives of the use of the entomopathogenic fungi beauveria bassiana and metarhizium anisopliae for the control of arthropod pests in poultry production
Serial spawning and batch fecundity of merluccius capensis and m. Paradoxus
Histological analysis of the ovaries and the presence of multiple modes in oocyte size frequency distribution of Cape hake Merluccius capensis and M. paradoxus indicates that they are serial spawners. Batch fecundity,calculated by means of the âhydrated oocyte methodâ, was positively correlated to ovary-free fish mass and total fish length. The mean relative fecundity (ovary-free mass) of M. capensis and M. paradoxus was 160 ± 12and 306 ± 25 eggs.g-1 respectively