ERP and four dimensions of absorptive capacity: lessons from a developing country

Enterprise resource planning systems can grant crucial strategic, operational and information-based benefits to adopting firms when implemented successfully. However, a failed implementation can often result in financial losses rather than profits. Until now, the research on the failures and successes were focused on implementations in large manufacturing and service organizations firms located in western countries, particularly in USA. Nevertheless, IT has gained intense diffusion to developing countries through declining hardware costs and increasing benefits that merits attention as much as developed countries. The aim of this study is to examine the implications of knowledge transfer in a developing country, Turkey, as a paradigm in the knowledge society with a focus on the implementation activities that foster successful installations. We suggest that absorptive capacity is an important characteristic of a firm that explains the success level of such a knowledge transfer.Publicad

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

New species of Annonaceae from Suriname

Arbor circ. 8 m alta. Ramuli novelli pilis sparsis adpressis, mox glabrescentes, nigrescentes. Petiolus crassus, rugosus, adpresse tomentosus, 6-9 mm longus; lamina chartacea, supra glabra et nitida praeter costam hirsutam, subtus pilis sparsis adpressis, anguste elliptica vel elliptica, 12-18 cm longa et 4.5-7 cm lata, apice sensim angustata in acumen 1 cm longum, basi late cuneata vel aliquantum rotundata et decurrens; costa supra paulo impressa, nervi secundarii utrinque 16-18, supra prominentes, subtus conspicue prominentes, reticulum venularum utrinque manifestum. Inflorescentiae axillares, (1)—2-florae; pedicelli stricti, sparse adpresse tomentosi, 1.2-1.5 cm longi, circ. ad tertiam inferiorem articulati. Sepala ovata, acuta, in vivo viridia, circ. 6 mm longa, extus sericea, intus apicem versus pubescentia ceterumque glabra et in sicco nigra, mox reflexa. Petala oblongo-obovata, apice rotundata, brunnea, extus sericea, intus tomentosa, interiora ad basim macula triangulari glabra, interiora circ. 1.5 cm longa, exteriora circ. 2 cm longa. Stamina 1.2 mm longa, disco connectivi umbonato, minute papilloso. Pistilla numerosa, circ. 2.5 mm longa, ovaria pilosa, styli glabri, stigmata setulosa. (Fructus ignotus). Suriname: Near confluence of Paloemeu and Tapanahoni Rivers, 3°20' N Lat., 55°27' W Long., riverside (Wessels Boer 1302, fl. April, holotype U)

Moutabea arianae, a new species of Polygalaceae from French Guiana and adjacent Brazil.

A new species of Moutabea (Polygalaceae), M. arianae, is described and illustrate

Curtia ayangannae, a new species of Gentianaceae from the Pakaraima Mountains, Guyana

A new species of Curtia (Gentianaceae: Saccifolieae), C. ayangannae L. Cobb & Jans.-Jac., from Mt Ayanganna, Guyana, is described and illustrated. The relationship between the genera Curtia, Tapeinostemon, and Saccifolium is discussed

Evaporation from a large lowland reservoir-observed dynamics and drivers during a warm summer

We study the controls on open water evaporation of a large lowland reservoir in the Netherlands. To this end, we analyse the dynamics of open water evaporation at two locations, Stavoren and Trintelhaven, at the border of Lake IJssel (1100ĝ€¯km2); eddy covariance systems were installed at these locations during the summer seasons of 2019 and 2020. These measurements were used to develop data-driven models for both locations. Such a statistical model is a clean and simple approach that can provide a direct indication of (and insight into) the most relevant input parameters involved in explaining the variance in open water evaporation, without making a priori assumptions regarding the process itself. We found that a combination of wind speed and the vertical vapour pressure gradient can explain most of the variability in observed hourly open water evaporation. This is in agreement with Dalton's model, which is a well-established model often used in oceanographic studies for calculating open water evaporation. Validation of the data-driven models demonstrates that a simple model using only two variables yields satisfactory results at Stavoren, with R2 values of 0.84 and 0.78 for hourly and daily data respectively. However, the validation results for Trintelhaven fall short, with R2 values of 0.67 and 0.65 for hourly and daily data respectively. Validation of the simple models that only use routinely measured meteorological variables shows adequate performance at hourly (R2Combining double low line0.78 at Stavoren and R2Combining double low line0.51 at Trintelhaven) and daily (R2Combining double low line0.82 at Stavoren and R2Combining double low line0.87 at Trintelhaven) timescales. These results for the summer periods show that open water evaporation is not directly coupled to global radiation at the hourly or daily timescale. Rather a combination of wind speed and vertical gradient of vapour pressure is the main driver at these timescales. We would like to stress the importance of including the correct drivers of open water evaporation in the parametrization in hydrological models in order to adequately represent the role of evaporation in the surface-Atmosphere coupling of inland waterbodies.Water Resource

Land Cover Control on the Drivers of Evaporation and Sensible Heat Fluxes: An Observation-Based Synthesis for the Netherlands

Land cover controls the land-atmosphere exchange of water and energy through the partitioning of solar energy into latent and sensible heat. Observations over all land cover types at the regional scale are required to study these turbulent flux dynamics over a landscape. Here, we aim to study how the control of daily and midday latent and sensible heat fluxes over different land cover types is distributed along three axes: energy availability, water availability and exchange efficiency. To this end, observations from 19 eddy covariance flux tower sites in the Netherlands, covering six different land cover types located within the same climatic zone, were used in a regression analysis to explain the observed dynamics and find the principle drivers. The resulting relative position of these sites along the three axes suggests that land cover partly explains the variance of daily and midday turbulent fluxes. We found that evaporation dynamics from grassland, peatland swamp and cropland sites could mostly be explained by energy availability. Forest evaporation can mainly be explained by water availability, urban evaporation by water availability and exchange efficiency, and open water evaporation can almost entirely be explained by exchange efficiency. We found that the sensible heat flux is less sensitive to land cover type. This demonstrates that the land-atmosphere interface plays an active role in the shedding of sensible heat. Our results contribute to a better understanding of the dynamics of evaporation over different land cover types and may help to optimize, and potentially simplify, models to predict evaporation.Water Resource