24 research outputs found
Supplementary material for the article: JanoviÄ, B. S.; Collins, A. R.; VujÄiÄ, Z. M.; VujÄiÄ, M. T. Acidic Horseradish Peroxidase Activity Abolishes Genotoxicity of Common Dyes. Journal of Hazardous Materials 2017, 321, 576ā585. https://doi.org/10.1016/j.jhazmat.2016.09.037
Supplementary material for: [10.1016/j.jhazmat.2016.09.037]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2356]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3189
Supplementary material for the article: ÄobeljiÄ, B.; MilenkoviÄ, M.; Pevec, A.; Turel, I.; VujÄiÄ, M.; JanoviÄ, B.; GligorijeviÄ, N.; SladiÄ, D.; RaduloviÄ, S.; JovanoviÄ, K.; et al. Investigation of Antitumor Potential of Ni(II) Complexes with Tridentate PNO Acylhydrazones of 2-(Diphenylphosphino)Benzaldehyde and Monodentate Pseudohalides. Journal of Biological Inorganic Chemistry 2016, 21 (2), 145ā162. https://doi.org/10.1007/s00775-015-1315-x
Supplementary material for: [https://doi.org/10.1007/s00775-015-1315-x]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1906
PO-129 In vitro radiosensitivity and repair kinetics of PBMCs from prostate cancer patients and healthy donors evaluated by comet assay
A high cellular radiosensitivity is connected with a risk for development of severe side effects after radiotherapy. In this study we have attempted to find a correlation between the initial radiosensitivity of in vitro irradiated peripheral blood mononuclear cells (PBMC) of prostate cancer patients and the adverse side effects of radiotherapy
A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells
A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies. Compared to 1, cisplatin (CDDP) does not achieve cell death in 2D cultured AsPC-1 cells, while induces different pattern of cell cycle changes and caspase activation in 2D cultured MCF-7 cells, implying that these two compounds do not share similar mechanism of action. Additionally, 1 acts as a powerful inducer of mitochondrial superoxide production with dissipated trans-membrane potential in the majority of the treated cells already after 6 h of incubation. On 3D tumors, 1 displays a superior activity against CSC model, and at 100 M induces disintegration of spheroids within 2 days of incubation. Fluorescence spectroscopy, along with molecular docking show that compound 1 binds to the minor groove of DNA. Compound 1 binds to the human serum albumin (HSA) showing that the HSA can effectively transport and store 1 in the human body. Thus, our current study strongly supports further investigations on antitumor activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer
Supplementary material for the article: BjelogrliÄ, S. K.; TodoroviÄ, T.; CvijetiÄ, I.; RodiÄ, M. V.; VujÄiÄ, M.; MarkoviÄ, S. B.; AraÅ”kov, J.; JanoviÄ, B.; Emhemmed, F.; Muller, C. D.; et al. A Novel Binuclear Hydrazone-Based Cd(II) Complex Is a Strong pro-Apoptotic Inducer with Significant Activity against 2D and 3D Pancreatic Cancer Stem Cells. Journal of Inorganic Biochemistry 2019, 190, 45ā66. https://doi.org/10.1016/j.jinorgbio.2018.10.002
Supplementary material for: [https://www.sciencedirect.com/science/article/pii/S016201341830360X?via%3Dihub]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/355]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/2796
Supplementary data for article: MarkoviÄ, V.; JaniÄijeviÄ, A.; StanojkoviÄ, T.; Kolundzija, B.; SladiÄ, D.; VujÄiÄ, M.; JanoviÄ, B.; JoksoviÄ, L.; Djurdjevic, P. T.; TodoroviÄ, N.; et al. Synthesis, Cytotoxic Activity and DNA-Interaction Studies of Novel Anthraquinone-Thiosemicarbazones with Tautomerizable Methylene Group. European Journal of Medicinal Chemistry 2013, 64, 228ā238. https://doi.org/10.1016/j.ejmech.2013.03.071
Supplementary material for: [https://doi.org/10.1016/j.ejmech.2013.03.071]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1370
PO-410 Cytotoxicity and genotoxicity of new gadolinium, iron oxide, cobalt ferrite and graphene oxide nanoparticles on some tumour cell lines in vitro
Nanoparticles (NPs) are increasingly used in cancer
therapy as delivery agents and in the diagnosis of malignant diseases
as contrast agents for magnetic resonance imaging (MRI).
The aim of this work was in vitro assessments of Gd-NPs, Fe-
NPs, CoFe-NPs and Graphene Oxide-NPs cytotoxicity and genotoxicity
on some tumour and normal human cell lines.Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June ā 3 July 201
Supplementary material for the article: ÄobeljiÄ, B.; MilenkoviÄ, M.; Pevec, A.; Turel, I.; VujÄiÄ, M.; JanoviÄ, B.; GligorijeviÄ, N.; SladiÄ, D.; RaduloviÄ, S.; JovanoviÄ, K.; et al. Investigation of Antitumor Potential of Ni(II) Complexes with Tridentate PNO Acylhydrazones of 2-(Diphenylphosphino)Benzaldehyde and Monodentate Pseudohalides. Journal of Biological Inorganic Chemistry 2016, 21 (2), 145ā162. https://doi.org/10.1007/s00775-015-1315-x
Supplementary material for: [https://doi.org/10.1007/s00775-015-1315-x]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1906
Supplementary data for the article: MarkoviÄ, V.; Debeljak, N.; StanojkoviÄ, T.; Kolundžija, B.; SladiÄ, D.; VujÄiÄ, M.; JanoviÄ, B.; TaniÄ, N.; PeroviÄ, M.; TeÅ”iÄ, V.; et al. Anthraquinone-Chalcone Hybrids: Synthesis, Preliminary Antiproliferative Evaluation and DNA-Interaction Studies. European Journal of Medicinal Chemistry 2015, 89, 401ā410. https://doi.org/10.1016/j.ejmech.2014.10.055
Supplementary material for: [https://doi.org/10.1016/j.ejmech.2014.10.055]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1903