5 research outputs found

    DESARROLLO DE PREMEZCLA DE HARINA DE TRIGO DURO OBTENIDA POR PROCESOS DE NIXTAMALIZADO TRADICIONAL Y MODIFICADO

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    Se hicieron pre-mezclas de harinas y se caracterizaron fisicoquímicamenteEn México, la producción de trigo tuvo un crecimiento promedio anual del 8.6% en 2014. El trigo es el cereal con mayor relevancia ocupando el segundo lugar con mayor volumen de producción y de consumo de grano en el país por ello es importante aprovechar este cereal para consumo humano. Las premezclas en la industria panadera son cada vez más usadas para la facilitación y minimización de errores en la elaboración de productos alimenticios. El presente estudio tuvo como objetivo aplicar el método de nixtamalización tradicional y modificado de trigo duro para la obtención de premezclas de harina con características físicas y químicas deseables para la industria panadera. Se nixtamalizaron muestras de 2 kg de trigo duro (contenido de humedad 12.7% y proteína 13.5%) con tratamiento modificado (1% CaOH2, 10 min, 60°C) y con tratamiento tradicional (1% CaOH2, 35 min, 95°C) dejándose en reposo por 16 horas ambos tratamientos y se realizaron premezclas con las harinas obtenidas y harina comercial Manitova®. Los resultados obtenidos en este estudio mostraron que se encontró diferencia significativa en el color y tamaño de grano, color de harina, contenido de gluten húmedo, y tamaño de partícula (p < 0.05) dependiendo el proceso de nixtamalización. También se encontró una mayor distribución de la red proteica en las premezclas de harinas elaboradas con trigo duro nixtamalizado modificado y la premezcla conteniendo 20% de trigo duro respecto al control y a la harina comercial, mientras que no hubo diferencia significativa en la capacidad de absorción de agua subjetiva en las diferentes harinas y premezclas

    The corporality of fear in boys and girls

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    El miedo es una emoción que hace parte del proceso evolutivo del hombre. Se manifiesta de diversas formas en cada sujeto de acuerdo su contexto social, cultural y familiar y cada individuo lo expresa de manera particular a través de su cuerpo, de sus palabras o de sus actos. Pero aun cuando sea algo natural, también puede desembocar en estados de malestar, de estrés y generar todo un conflicto emocional que afecta tanto de manera física como mental. Este trabajo busca conocer específicamente la mirada de los niños respecto a lo que es el miedo y cómo afecta su cuerpo, su desarrollo y su forma de vivir la realidad. Para ello se propusieron espacios de expresión donde el diálogo, la lectura, la escritura, el dibujo, entre otras herramientas, trazaron la ruta para aprender de los niños y niñas y a partir de sus narraciones establecer el mejor camino para ayudarlos a enfrentar sus temores y además romper el paradigma de juzgar a los niños por sentir miedo.Fear is an emotion that is part of the evolutionary process of man. It manifests itself in different ways in each subject according to their social, cultural and family context and each individual expresses it in a particular way through their body, their words or their actions. But even when it is something natural, it can also lead to states of discomfort, stress and generate an emotional conflict that affects both physically and mentally. This work seeks to know specifically the perspective of children regarding what fear is and how it affects their body, their development and their way of living reality. For this, spaces of expression were proposed where dialogue, reading, writing, drawing, among other tools, traced the route to learn from children and, based on their narrations, establish the best path to help them face their fears

    Preoperative concurrent radiation therapy and chemotherapy for bulky stage IB2, IIA, and IIB carcinoma of the uterine cervix with proximal parametrial invasion.

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    International audiencePURPOSE: To evaluate toxicity, local tumor control, and survival after preoperative chemoradiation for operable bulky cervical carcinoma. METHODS AND MATERIALS: Between December 1991 and July 2006, 92 patients with operable bulky stage IB2, IIA, and IIB cervical carcinoma without pelvic or para-aortic nodes on pretreatment imaging were treated. Treatment consisted of preoperative external beam pelvic radiation therapy (EBRT) and concomitant chemotherapy (CT) during the first and fourth weeks of radiation combining 5-fluorouracil and cisplatin. The pelvic radiation dose was 40.5 Gy over 4.5 weeks. EBRT was followed by low-dose rate uterovaginal brachytherapy with a total dose of 20 Gy in 62 patients. After a median rest period of 44 days, all patients underwent Class II modified radical hysterectomy with bilateral pelvic lymphadenectomy. Thirty patients who had not received preoperative uterovaginal brachytherapy underwent postoperative low-dose-rate vaginal brachytherapy at a dose of 20 Gy. The mean follow-up was 46 months. RESULTS: Pathologic residual tumor was observed in 43 patients. After multivariate analysis, additional preoperative uterovaginal brachytherapy was the single significant predictive factor for pathologic complete response rate (p = 0.019). The 2- and 5-year disease-free survival (DFS) rates were 80.4% and 72.2%, respectively. Pathologic residual cervical tumor was the single independent factor decreasing the probability of DFS (p = 0.020). Acute toxicities were moderate. Two severe ureteral complications requiring surgical intervention were observed. CONCLUSIONS: Concomitant chemoradiation followed by surgery for operable bulky stage I-II cervical carcinoma without clinical lymph node involvement can be used with acceptable toxicity. Pathologic complete response increases the probability of DFS

    Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

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    International audienceMemory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute to long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide SARS-CoV-2 immunoprofiling in Wuhan COVID-19 convalescents combining serological, cellular, and monoclonal antibody explorations revealed humoral immunity coordination. Detailed characterization of a hundred SARS-CoV-2 spike memory B-cell monoclonal antibodies uncovered diversity in their repertoire and antiviral functions. The latter were influenced by the targeted spike region with strong Fc-dependent effectors to the S2 subunit and potent neutralizers to the receptor-binding domain. Amongst those, Cv2.1169 and Cv2.3194 antibodies cross-neutralized SARS-CoV-2 variants of concern, including Omicron BA.1 and BA.2. Cv2.1169, isolated from a mucosa-derived IgA memory B cell demonstrated potency boost as IgA dimers and therapeutic efficacy as IgG antibodies in animal models. Structural data provided mechanistic clues to Cv2.1169 potency and breadth. Thus, potent broadly neutralizing IgA antibodies elicited in mucosal tissues can stem SARS-CoV-2 infection, and Cv2.1169 and Cv2.3194 are prime candidates for COVID-19 prevention and treatment
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