L-DOPA effect on speech dysprosody in Parkinson's disease:an acoustic and aerodynamic study

International audienceWe try to quantify the changes induced by L-DOPA treatment in a large population of parkinsonian patients: - on pitch, intensity and oral airflow mean values during a sustained vowel task.- on speech dysprosody during a reading task (mean F0 and tonal range). - on subglottal pressure (assessed via the intra-oral pressure) during sentence production

Speech prosody impairments in Parkinson's disease : an acoustic analysis

International audienceBackground ; Prosodic features (pitch and intensity variation, pauses,rate) play a crucial role, besides the articulatory ones, on the intelligibility of ail languages around the world, namely in french.Objective : To indentify and to quantify the speech prosody impairments in Parkinson's disease (PD)Methods : 10 PD male patients (mean age : 57 y, mean disease duration : 9 y) were compared with 10 male controls (mean age : 59 y). AII subjects, after informed consent, were recorded during a loud voice reading task of a text (1 mn duration) with an acoustic system (EVA 2, SQ-lab, France). The PD patients were in OFF L. DOPA status (overnight washout > 12 hours). The distribution of tonal and intensity ranges (with mean fundamental frequency Fo in Hz and mean intensity in dB) were calculated, using the melodic tonal and intensity curves. The distribution and duration of silent pauses and the duration of vowels and consonants were also measured systematically from the acoustic signal. Statistical comparisons were made between PD patients and control sujects (paired Student's t test : significance at p Results : A significant reduction in mean Fo and in mean intensity was observed in PD patients, with lack of the upper part of the tonal range, thus resulting also in the reduction of variability in pitch and intensity. The silent pauses duration and the mean vowel duration were significantly increased in PD patients, whereas the mean consonant duration was decreased in PD patients. Conclusion : This acoustic approach can provide an objective and quantitative assessment of the speech dysprosody in Parkinson's disease, thus completing the classical perceptual assessment more focused on the articulatory disorders.Acknowledgments : this study was supported by PHRC 2003 and France Parkinson.<BR /

Chasing Gravitational Waves with the Chereknov Telescope Array

Presented at the 38th International Cosmic Ray Conference (ICRC 2023), 2023 (arXiv:2309.08219)2310.07413International audienceThe detection of gravitational waves from a binary neutron star merger by Advanced LIGO and Advanced Virgo (GW170817), along with the discovery of the electromagnetic counterparts of this gravitational wave event, ushered in a new era of multimessenger astronomy, providing the first direct evidence that BNS mergers are progenitors of short gamma-ray bursts (GRBs). Such events may also produce very-high-energy (VHE, > 100GeV) photons which have yet to be detected in coincidence with a gravitational wave signal. The Cherenkov Telescope Array (CTA) is a next-generation VHE observatory which aims to be indispensable in this search, with an unparalleled sensitivity and ability to slew anywhere on the sky within a few tens of seconds. New observing modes and follow-up strategies are being developed for CTA to rapidly cover localization areas of gravitational wave events that are typically larger than the CTA field of view. This work will evaluate and provide estimations on the expected number of of gravitational wave events that will be observable with CTA, considering both on- and off-axis emission. In addition, we will present and discuss the prospects of potential follow-up strategies with CTA

Sensitivity of the Cherenkov Telescope Array to the gamma-ray emission from neutrino sources detected by IceCube

Gamma-ray observations of the astrophysical neutrino sources are fundamentally important for understanding the underlying neutrino production mechanism. We investigate the Cherenkov Telescope Array (CTA) ability to detect the very-high-energy (VHE) gamma-ray counterparts to the neutrino-emitting Active Galaxies. The CTA performance under different configurations and array layouts is computed based on the neutrino and gamma-ray simulations of steady and transient types of sources, assuming that the neutrino events are detected with the IceCube neutrino telescope. The CTA detection probability is calculated for both CTA sites taking into account the visibility constraints. We find that, under optimal observing conditions, CTA could observe the VHE gamma-ray emission from at least 3 neutrino events per year

Chasing Gravitational Waves with the Chereknov Telescope Array

Presented at the 38th International Cosmic Ray Conference (ICRC 2023), 2023 (arXiv:2309.08219)2310.07413International audienceThe detection of gravitational waves from a binary neutron star merger by Advanced LIGO and Advanced Virgo (GW170817), along with the discovery of the electromagnetic counterparts of this gravitational wave event, ushered in a new era of multimessenger astronomy, providing the first direct evidence that BNS mergers are progenitors of short gamma-ray bursts (GRBs). Such events may also produce very-high-energy (VHE, > 100GeV) photons which have yet to be detected in coincidence with a gravitational wave signal. The Cherenkov Telescope Array (CTA) is a next-generation VHE observatory which aims to be indispensable in this search, with an unparalleled sensitivity and ability to slew anywhere on the sky within a few tens of seconds. New observing modes and follow-up strategies are being developed for CTA to rapidly cover localization areas of gravitational wave events that are typically larger than the CTA field of view. This work will evaluate and provide estimations on the expected number of of gravitational wave events that will be observable with CTA, considering both on- and off-axis emission. In addition, we will present and discuss the prospects of potential follow-up strategies with CTA

Interpolation of Instrument Response Functions for the Cherenkov Telescope Array in the Context of pyirf

The Cherenkov Telescope Array (CTA) will be the next generation ground-basedvery-high-energy gamma-ray observatory, constituted by tens of Imaging AtmosphericCherenkov Telescopes at two sites once its construction and commissioning are finished. Like its predecessors, CTA relies on Instrument Response Functions (IRFs) to relate the observed and reconstructed properties to the true ones of the primary gamma-ray photons. IRFs are needed for the proper reconstruction of spectral and spatial information of the observed sources and are thus among the data products issued to the observatory users. They are derived from Monte Carlo simulations, depend on observation conditions likethe telescope pointing direction or the atmospheric transparency and can evolve with time as hardware ages or is replaced. Producing a complete set of IRFs from simulations for every observation taken is a time-consuming task and not feasible when releasing data products on short timescales. Consequently, interpolation techniques on simulated IRFs are investigated to quickly estimate IRFs for specific observation conditions. However, as some of the IRFs constituents are given as probability distributions, specialized methods are needed. This contribution summarizes and compares the feasibility of multiple approaches to interpolate IRF components in the context of the pyirf python software package and IRFs simulated for the Large-Sized Telescope prototype (LST-1). We will also give an overview of the current functionalities implemented in pyirf

Expected exclusion limits to TeV dark matter from the Perseus Cluster with the Cherenkov Telescope Array

Clusters of galaxies are the largest gravitationally-bound structures in the Universe. They are composed of galaxies and gas (approximately 15% of the total mass) mostly dark matter (DM, accounts up to 85% of the total mass). If the DM is composed of Weakly Interacting Massive Particles (WIMPs), galaxy clusters represent one of the best targets to search for gamma-ray signals induced by the decay of WIMPs, with masses around the TeV scale. Due to its sensitivity and energy range of operation (from 20 GeV to 300 TeV), the Cherenkov Telescope Array (CTA) Observatory has a unique opportunity to test WIMPs with masses close to the unitarity limit. This will complement the searches for DM from other gamma-ray observatories as well as direct and collider experiments. The CTA Observatory is planning to search for gamma-ray emission, either its origin may be cosmic-ray (CR) or DM related, in the Perseus galaxy cluster during the first years of operation. In this poster, we will present the software created to perform the analysis using the \texttt{ctools} software and the corresponding results

Performance of a proposed event-type based analysis for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) will be the next-generation observatory in the field of very-high-energy (20 GeV to 300 TeV) gamma-ray astroparticle physics. Classically, data analysis in the field maximizes sensitivity by applying quality cuts on the data acquired. These cuts, optimized using Monte Carlo simulations, select higher quality events from the initial dataset. Subsequent steps of the analysis typically use the surviving events to calculate one set of instrument response functions (IRFs). An alternative approach is the use of event types, as implemented in experiments such as the Fermi-LAT. In this approach, events are divided into sub-samples based on their reconstruction quality, and a set of IRFs is calculated for each sub-sample. The sub-samples are then combined in a joint analysis, treating them as independent observations. This leads to an improvement in performance parameters such as sensitivity, angular and energy resolution. Data loss is reduced since lower quality events are included in the analysis as well, rather than discarded. In this study, machine learning methods will be used to classify events according to their expected angular reconstruction quality. We will report the impact on CTA high-level performance when applying such an event-type classification, compared to the classical procedure

Variability studies of active galactic nuclei from the long-term monitoring program with the Cherenkov Telescope Array

Blazars are active galactic nuclei (AGN) with a relativistic jet oriented toward the observer. This jet is composed of accelerated particles which can display emission over the entire electromagnetic spectrum. Spectral variability has been observed on short- and long-time scales in AGN, with a power spectral density (PSD) that can show a break at frequencies below the well-known red-noise process. This break frequency in the PSD has been observed in X-rays to scale with the accretion regime and the mass of the central black hole. It is expected that a break could also be seen in the very-high-energy gamma rays, but constraining the shape of the PSD in these wavelengths has not been possible with the current instruments. The Cherenkov Telescope Array (CTA) will be more sensitive by a factor of five to ten depending on energy than the current generation of imaging atmospheric Cherenkov telescopes, therefore it will be possible with CTA to reconstruct the PSD with a high accuracy, bringing new information about AGN variability. In this work, we focus on the AGN long-term monitoring program planned with CTA. The program is proposed to begin with early-start observing campaigns with CTA precursors. This would allow us to probe longer time scales on the AGN PSD