Total synthesis of zincophorin*

Abstract: A total synthesis of the naturally occurring ionophore zincophorin has been realized. The key steps are an intramolecular oxymercuration of a cyclopropanemethanol for the elaboration of the tetrahydropyran ring and a Carroll-Claisen rearrangement to control the configuration of the double bond at C20-C21 as well as the stereogenic center at C21

Cobalt-Catalyzed alpha-Arylation of Substituted alpha-Bromo alpha-Fluoro beta-Lactams with Diaryl Zinc Reagents : Generalization to Functionalized Bromo Derivatives

A cobalt-catalyzed cross-coupling of alpha-bromo alpha-fluoro beta-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of beta-lactams. The substrate scope was expanded to alpha-bromo lactams and amides, alpha-bromo lactones and esters as well asN- and O-containing heterocycles.Peer reviewe

Mecanismo de accion de los macrolidos citotoxicos amphinolidas X y J

Trabajo presentado en el XI Congreso de la Sociedad de Biofísica de España: "XXV años y más allá", celebrado en Murcia (España) , del 1 al 4 de junio de 201

Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J

Peer reviewe