Structure, tools, discourse and practices: a multidimensional comparative approach to EU territorial governance

The concept of "EU territorial governance" has been recently adopted by planners and decision-makers to indicate the occurrence of a complex, multifaceted and largely undefined process of spatial planning and development activities guided, at various levels, in the European Union's institutional context. Building on a EU territorial governance conceptual framework elaborated by the authors in previous work, which individuates the specific „channels‟ of interaction that convey change in European countries, on the one hand, and institutional progress at the EU level, on the other hand, the contribution aims to shed some light on the differential impact exerted by such channels as they manifests in relation to different Member States domestic contexts. It does so by adopting three different national contexts as case studies, representative of as many „ideal types‟ of planning system traditions existing in Europe - namely , „comprehensive integrated‟ (Germany), „urbanism‟ (Italy), plus a supposed „Central and Eastern European socialist transition‟ type (Poland) - and providing a comparative analysis of the elements that, in relation to each of them, influence the evolution of European spatial planning and spatial planning domestic contexts within the complex framework of EU territorial governanc

Structure, tools, discourse and practices: a multidimensional comparative approach to EU territorial governance

The concept of "EU territorial governance" has been recently adopted by planners and decision-makers to indicate the occurrence of a complex, multifaceted and largely undefined process of spatial planning and development activities guided, at various levels, in the European Union's institutional context. Building on a EU territorial governance conceptual framework elaborated by the authors in previous work, which individuates the specific „channels‟ of interaction that convey change in European countries, on the one hand, and institutional progress at the EU level, on the other hand, the contribution aims to shed some light on the differential impact exerted by such channels as they manifests in relation to different Member States domestic contexts. It does so by adopting three different national contexts as case studies, representative of as many „ideal types‟ of planning system traditions existing in Europe – namely , „comprehensive integrated‟ (Germany), „urbanism‟ (Italy), plus a supposed „Central and Eastern European socialist transition‟ type (Poland) – and providing a comparative analysis of the elements that, in relation to each of them, influence the evolution of European spatial planning and spatial planning domestic contexts within the complex framework of EU territorial governance

Influence of correlations on molecular recognition

The influence of the patchiness and correlations in the distribution of hydrophobic and polar residues at the interface between two rigid biomolecules on their recognition ability is investigated in idealised coarse-grained lattice models. A general two-stage approach is utilised where an ensemble of probe molecules is designed first and the recognition ability of the probe ensemble is related to the free energy of association with both the target molecule and a different rival molecule in a second step. The influence of correlation effects are investigated using numerical Monte Carlo techniques and mean field methods. Correlations lead to different optimum characteristic lengths of the hydrophobic and polar patches for the mutual design of the two biomolecules on the one hand and their recognition ability in the presence of other molecules on the other hand.Comment: 15 pages, 5 figure

Does One Size Fit All? Drug Resistance and Standard Treatments: Results of Six Tuberculosis Programmes in Former Soviet Countries.

SETTING: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance. OBJECTIVE: To discuss the relevance of the DOTS strategy in settings with a high prevalence of drug resistance. DESIGN: Retrospective analysis of one-year treatment outcomes of short-course chemotherapy (SCC) and results of drug susceptibility testing (DST) surveys of six programmes located in the former Soviet Union: Kemerovo prison, Russia; Abkhasia, Georgia; Nagorno-Karabagh, Azerbaijan; Karakalpakstan, Uzbekistan; Dashoguz Velayat, Turkmenistan; and South Kazakhstan Oblast, Kazakhstan. Results are reported for new and previously treated smear-positive patients. RESULTS: Treatment outcomes of 3090 patients and DST results of 1383 patients were collected. Treatment success rates ranged between 87% and 61%, in Nagorno-Karabagh and Kemerovo, respectively, and failure rates between 7% and 23%. Any drug resistance ranged between 66% and 31% in the same programmes. MDR rates ranged between 28% in Karakalpakstan and Kemerovo prison and 4% in Nagorno-Karabagh. CONCLUSION: These results show the limits of SCC in settings with a high prevalence of drug resistance. They demonstrate that adapting treatment according to resistance patterns, access to reliable culture, DST and good quality second-line drugs are necessary

Walking automata in free inverse monoids

International audienceWalking automata, be they running over words, trees or even graphs, possibly extended with pebbles that can be dropped and lifted on vertices, have long been defined and studied in Computer Science. However, questions concerning walking automata are surprisingly complex to solve. In this paper, we study a generic notion of walking automata over graphs whose semantics naturally lays within inverse semigroup theory. Then, from the simplest notion of walking automata on birooted trees, that is, elements of free inverse monoids, to the more general cases of walking automata on birooted finite subgraphs of Cayley's graphs of groups, that is, elements of free E-unitary inverse monoids, we provide a robust algebraic framework in which various classes of recognizable or regular languages of birooted graphs can uniformly be defined and related one with the other

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer

Genetic and epigenetic changes deregulate RNA and protein expression in cancer cells. In this regard, tumors exhibit an abnormal proteome in comparison to the corresponding normal tissues. Translation control is a crucial step in the regulation of gene expression regulation under normal and pathological conditions that ultimately determines cellular fate. In this context, evidence shows that transfer and ribosomal RNA (tRNA and rRNA) modifications affect the efficacy and fidelity of translation. The number of RNA modifications increases with the complexity of organisms, suggesting an evolutionary diversification of the possibilities for fine-tuning the functions of coding and non-coding RNAs. In this review, we focus on alterations of modifications of transfer and ribosomal RNA that affect translation in human cancer. This variation in the RNA modification status can be the result of altered modifier expression (writers, readers or erasers), but also due to components of the machineries (C/D or H/ACA boxes) or alterations of proteins involved in modifier expression. Broadening our understanding of the mechanisms by which site-specific modifications modulate ribosome activity in the context of tumorigenesis will enable us to enrich our knowledge about how ribosomes can influence cell fate and form the basis of new therapeutic opportunities

ESPON Project 2.3.1., Application and effects of the ESDP in Member States. First Interim Report

This First Interim Report includes the initial results of the project “Application and Effects of the ESDP in the Member States” within the ESPON Programme 2000-2006. The focus of the study is the application of the European Spatial Development Perspective (ESDP), which was adopted at the Potsdam European Council meeting in May 1999

Alpine Space Prospective Study. Sustainable territorial development in the Alpine Space: Towards long term transnational cooperation

This "Prospective Study" argues that a long term transnational cooperation will be able to pursue the sustainable territorial development in the Alpine Space only at the condition of a substantial improvement of the current experience. This regards an increased awareness of the complexity of issues and challenges currently at stake in the Alpine area but especially, in this light, the capacity of involving all relevant institutional and socioeconomic stakeholders in the building of shared transnational strategie