Ethno medicinal plants with anticonvulsant activity through GABAergic mechanism- A review

Humanity has used immemorial plants for their relieving and healing powers from era and we still depend on their healing properties. Plants with number of active constituents have a direct therapeutic impact on various body organs. Brain is one of major organ linked to various disorders, one of them is epilepsy. Owing to undesirable side effects, high expense and reduced effectiveness of conventional drugs, traditional plants are deemed appropriate for the treatment of epilepsy. The potential of natural products for the treatment of epilepsy can be an excellent alternative for the development of safe and effective anti-epileptic drugs. The present bibliographic review presents the data upto 2021. Plants were screened for citing the research work done for epilepsy, efficacy of plants along with their mechanism of action, plant profile, part used, dose, extract used, toxicity study and model used. Also isolated compounds have been compiled along with their structure. A total of 120 review and research articles of plants which revealed their effective therapeutic effects on epilepsy through GABAergic transmission belonging to families lamiaceae(11), fabaceae(5), zingiberaceae(3), moraceae(3), verbenaceae(3), and apiaceae(2). The data discussed might be useful in formulating new chemical entity for the treatment of epilepsy. The documentation of isolated compounds may provide new drug molecules for market with lesser cost and more efficacy

The Sien And Sollen Of CSR In India

Corporate Social Responsibility (CSR) has emerged as a new hallmark of good governance, focusing on corporate responsiveness and societal norms for a nation's economic growth and development. It is a way forward for eco- efficiency and social equity following the "Triple Bottom Line Approach," which maintains a balance between economic, environmental, and social imperatives. The purpose of this paper is to renounce the ideological meaning and provide concluding remarks on CSR's contribution to sustainability by conceptualising the various aspects of organisational performance. The paper also emphasised the legality of CSR and its effect as per mandated provisions for social progress and environmental protection. CSR has evolved into a tool in the modern era that adheres to legal requirements and strives to increase the productivity of social welfare activities. It is believed that the CSR initiative will strive to move the nation towards the achievement of sustainable development goals and a public- private partnership in transforming India

Ethno medicinal plants with anticonvulsant activity through GABAergic mechanism- A review

274-286Humanity has used immemorial plants for their relieving and healing powers from era and we still depend on their healing properties. Plants with number of active constituents have a direct therapeutic impact on various body organs. Brain is one of major organ linked to various disorders, one of them is epilepsy. Owing to undesirable side effects, high expense and reduced effectiveness of conventional drugs, traditional plants are deemed appropriate for the treatment of epilepsy. The potential of natural products for the treatment of epilepsy can be an excellent alternative for the development of safe and effective anti-epileptic drugs. The present bibliographic review presents the data upto 2021. Plants were screened for citing the research work done for epilepsy, efficacy of plants along with their mechanism of action, plant profile, part used, dose, extract used, toxicity study and model used. Also isolated compounds have been compiled along with their structure. A total of 120 review and research articles of plants which revealed their effective therapeutic effects on epilepsy through GABAergic transmission belonging to families lamiaceae(11), fabaceae(5), zingiberaceae(3), moraceae(3), verbenaceae(3), and apiaceae(2). The data discussed might be useful in formulating new chemical entity for the treatment of epilepsy. The documentation of isolated compounds may provide new drug molecules for market with lesser cost and more efficacy

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved under mild reaction conditions. Several α,β,γ,δ-unsaturated aldehydes and diarylcarbinols are successfully tested for the synthesis of MBH-type α-alkylated products with an excellent regioselectivity. Simple pyrrolidine is efficiently used as a catalyst to achieve a perfect E/Z selectivity of the α-alkylated products.by Venkata M. D Padmaja,, Sachin Jangra and Chandrakumar Appaye

Nutritional Benefits of Fish Consumption for Humans: A Review

In conquest to attain the goal of zero hunger as well as tackling the problem of malnutrition worldwide, fish proves to be one of the best functional food to humans. Along with the sense of good taste to humans, it ensures great nutritional value at an affordable price. Fish food plays an active role in providing nutrients to the body that are directly involved in metabolic activities. It is enriched with high quality protein containing all the essential amino acids, omega-3 polyunsaturated fatty acids including eicosapentanoic acid and docosahexaenoic acid. Also, it provides wide variety of micronutrients involving vitamins (fat soluble vitamins and several members of vitamin B complex) and minerals. Also, these have significant protective effects against the occurrences of several diseases such as cancer, cardiovascular diseases, inflammatory diseases, retinopathy, diabetes, arthritis and some other acute or chronic diseases. The bioactive peptides from fish food are reported for their positive effect on humans. Therefore, fish is an optimal choice of food to humans as it helps in their growth, development and maintenance of good health. However, care should be taken during processing of fish or fish products as the inappropriate handling can deteriorate the nutritional quality of the food

Kinetics and inhibitory studies on IMPDH protein against Helicobacter pylori

by Gayathri Purushothaman, Gaurav Sharma, Srimadhavi R, Sachin Jangra, Vijay Thiruvenkatam and Sivapriya Kirubakara

An Efficient Three-Phase Fuzzy Logic Clone Node Detection Model

Wireless sensor networks have been deployed in the open and unattended environment where the attacker can capture the sensors and create the replica of captured nodes. As the clone nodes have been considered legitimate nodes, clone nodes can initiate different network attacks. We have designed a three-phase clone node detection method named fuzzy logic clone node detection (FLCND). The first phase of FLCND checks whether any node is missing from the network or not. In the next phase, FLCND finds out whether any missing node has arisen in the network in a stipulated time. If any missing node is alive, there is a possibility the node may be cloned. The information of suspected nodes is entered into the Hot-List, which has been maintained in the network. Phase III uses the suspected list and finds out the possibility of clone node using fuzzy logic. Two different scenarios have been simulated in NS2 to evaluate FLCND. The simulation result shows that the proposed method increases the packet delivery ratio (PDR) and reduces packet loss, end-to-end delay, and energy consumption. The simulation results illustrate that the FLCND method reduces the average power consumption by 27% and increases the detection rate by 46% compared to the existing techniques

Kinetics and structural features of IMPDH: possible target for treating H pylori infection

by Gayathri Purushothaman, Gaurav Sharma, Srimadhavi R., Sachin Jangra, Vijay Thiruvenkatam, and Sivapriya Kirubakara