Conceptualizing human resilience in the face of the global epidemiology of cyber attacks

Computer security is a complex global phenomenon where different populations interact, and the infection of one person creates risk for another. Given the dynamics and scope of cyber campaigns, studies of local resilience without reference to global populations are inadequate. In this paper we describe a set of minimal requirements for implementing a global epidemiological infrastructure to understand and respond to large-scale computer security outbreaks. We enumerate the relevant dimensions, the applicable measurement tools, and define a systematic approach to evaluate cyber security resilience. From the experience in conceptualizing and designing a cross-national coordinated phishing resilience evaluation we describe the cultural, logistic, and regulatory challenges to this proposed public health approach to global computer assault resilience. We conclude that mechanisms for systematic evaluations of global attacks and the resilience against those attacks exist. Coordinated global science is needed to address organised global ecrime

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.

Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S. aureus tested, including methicillin-susceptible, methicillin-resistant (MRSA) and vancomycin-resistant strains of S. aureus, were susceptible to anthracimycin at MIC values of ⩽0.25 mg l(-1). Although its postantibiotic effects were minimal, anthracimycin exhibited potent and rapid bactericidal activity, with a >4-log kill of USA300 MRSA within 3 h at five times its MIC. At concentrations significantly below the MIC, anthracimycin slowed MRSA growth and potentiated the bactericidal activity of the human cathelicidin, LL-37. The bactericidal activity of anthracimycin was somewhat mitigated in the presence of 20% human serum, and the compound was minimally toxic to human cells, with an IC50 (inhibitory concentration 50)=70 mg l(-1) against human carcinoma cells. At concentrations near the MIC, anthracimycin inhibited S. aureus nucleic acid synthesis as determined by optimized macromolecular synthesis methodology, with inhibition of DNA and RNA synthesis occurring in the absence of DNA intercalation. Anthracimycin at a single dose of 1 or 10 mg kg(-1) was able to protect mice from MRSA-induced mortality in a murine peritonitis model of infection. Anthracimycin provides an interesting new scaffold for future development of a novel MRSA antibiotic

Testosterone Administration Decreases Generosity in the Ultimatum Game

How do human beings decide when to be selfish or selfless? In this study, we gave testosterone to 25 men to establish its impact on prosocial behaviors in a double-blind within-subjects design. We also confirmed participants' testosterone levels before and after treatment through blood draws. Using the Ultimatum Game from behavioral economics, we find that men with artificially raised T, compared to themselves on placebo, were 27% less generous towards strangers with money they controlled (95% CI placebo: (1.70, 2.72); 95% CI T: (.98, 2.30)). This effect scales with a man's level of total-, free-, and dihydro-testosterone (DHT). Men in the lowest decile of DHT were 560% more generous than men in the highest decile of DHT. We also found that men with elevated testosterone were more likely to use their own money punish those who were ungenerous toward them. Our results continue to hold after controlling for altruism. We conclude that elevated testosterone causes men to behave antisocially

Religion and rehabilitation in Colombian and South African prisons : a human flourishing approach

This paper examines whether and how religion contributes to prisoner rehabilitation—conceptualized as a prosocial change in self-identity, existential belief, and character based on identity theories of criminal desistance, the “Good Lives Model” of offender rehabilitation, and the concept of human flourishing. For this study, we conducted a quasi-experimental study assessing a faith-based program, “The Prisoner's Journey” (TPJ). We hypothesized that participation in TPJ increased religiosity, which in turn contributed to rehabilitation, measured by identity transformation, a new sense of meaning and purpose in life, and virtue development. It was also hypothesized that prisoner rehabilitation enhanced emotional well-being and reduced the risk of interpersonal aggression. To test our hypotheses, we applied structural equation modeling to analyze data from 506 prisoners in Colombia and South Africa, who participated in pretest and posttest surveys. As hypothesized, we found that completion of TPJ increased religiosity, which in turn fostered motivation for identity change, the perception of meaning and purpose in life, and the virtues of forgiveness, accountability, and self-control. In addition, the increased perception of meaning and purpose in life and two virtues (forgiveness and self-control) decreased negative emotions and the risk of interpersonal aggression. The implications and limitations of our study are discussed.https://journals.sagepub.com/home/ICJhj2023Social Work and Criminolog

Enteric bacterial pathogen detection in southern sea otters (Enhydra lutris nereis) is associated with coastal urbanization and freshwater runoff

Although protected for nearly a century, California’s sea otters have been slow to recover, in part due to exposure to fecally-associated protozoal pathogens like Toxoplasma gondii and Sarcocystis neurona. However, potential impacts from exposure to fecal bacteria have not been systematically explored. Using selective media, we examined feces from live and dead sea otters from California for specific enteric bacterial pathogens (Campylobacter, Salmonella, Clostridium perfringens, C. difficile and Escherichia coli O157:H7), and pathogens endemic to the marine environment (Vibrio cholerae, V. parahaemolyticus and Plesiomonas shigelloides). We evaluated statistical associations between detection of these pathogens in otter feces and demographic or environmental risk factors for otter exposure, and found that dead otters were more likely to test positive for C. perfringens, Campylobacter and V. parahaemolyticus than were live otters. Otters from more urbanized coastlines and areas with high freshwater runoff (near outflows of rivers or streams) were more likely to test positive for one or more of these bacterial pathogens. Other risk factors for bacterial detection in otters included male gender and fecal samples collected during the rainy season when surface runoff is maximal. Similar risk factors were reported in prior studies of pathogen exposure for California otters and their invertebrate prey, suggesting that land-sea transfer and/or facilitation of pathogen survival in degraded coastal marine habitat may be impacting sea otter recovery. Because otters and humans share many of the same foods, our findings may also have implications for human health

Religion and responsibility-taking among offenders in Colombia and South Africa : a qualitative assessment of a faith-based program in prison

This paper examines whether religion contributes to offenders taking responsibility for crimes. Specifically, we assessed whether participation in The Prisoner’s Journey (TPJ), a bible study program, increased or decreased responsibility-taking. We also examined whether religious offenders that did not participate in TPJ were likely to take responsibility for their offenses. For this study, we conducted a quasi-experiment in two Colombian and five South African prisons from 2018 to 2019, collecting data from personal interviews with a total of 73 inmates—42 TPJ participants and 31 non-participants—before and after the program. Offenders frequently offered subtle accounts of responsibility that incorporated their own agency with other factors. Highly religious offenders were equally likely to take responsibility, and in some cases participation in TPJ heightened responsibility. In sum, this paper presents evidence that religious beliefs and practice are commensurate with responsibility-taking and desistance from crime.https://journals.sagepub.com/home/ijohj2023Social Work and Criminolog