66 research outputs found

    Meta-analysis with prior studies of the association between rs17577 and PAC/PACG.

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    <p>Odds ratio was calculated per each increase in minor allele A. The summary odds ratio was 1.71 (95% CI: 1.09–2.67) for the Caucasian population, 1.20 (95% CI: 0.99–1.45) for the Chinese populations, and 1.26 (95%CI: 1.06–1.50) for the combined Caucasian + Chinese populations, respectively. The odds ratios between the Caucasian and Chinese datasets were not significantly heterogeneous (<i>Q</i> = 0.15, <i>I</i><sup><i>2</i></sup> = 52%). The Bonferroni corrected significance level was set as 0.01 (0.05/5).</p

    Linkage disequilibrium plot of the 6 tag SNPs around <i>MMP9</i> in the Chinese dataset of this study.

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    <p>The numbers in the diamond indicate r<sup>2</sup>; black represented r<sup>2</sup> = 1, shades of grey indicated 0< r<sup>2</sup> <1, and white referred to r<sup>2</sup> = 0. Chromosomal positions were based on NCBI build 36.3 (National Center for Biotechnology Information, Bethesda, MD).</p

    Meta-analysis with prior studies of the association between rs3918249 and PAC/PACG.

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    <p>Odds ratio was calculated per each increase in minor allele T. The summary odds ratio was 0.63 (95% CI: 0.45–0.88) for the Caucasian population and 0.91 (95% CI: 0.80–1.03) for the Chinese populations. Significant heterogeneity between the Caucasian and Chinese populations precluded an overall meta-analysis for rs3918249 (<i>Q</i> = 0.04, <i>I</i><sup><i>2</i></sup> = 75%). The Bonferroni corrected significance level was set as 0.01 (0.05/5).</p

    Meta-analysis with prior studies of the association between rs17576 and PAC/PACG.

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    <p>Odds ratio was calculated per each increase in minor allele A. The summary odds ratio was 0.56 (95% CI: 0.42–0.74) for the non-Chinese populations and 1.23 (95% CI: 0.83–1.82) for the Chinese populations. Significant heterogeneity between the non-Chinese and Chinese populations precluded an overall meta-analysis for rs17576 (<i>Q</i> = 0.001, <i>I</i><sup><i>2</i></sup> = 90%). The Bonferroni corrected significance level was set as 0.01 (0.05/5).</p

    Sample selection process.

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    <p>Sample selection process for identifying elgible enrollees for the analysis.</p

    Multivariable analysis: risk factors for open-angle glaucoma<sup>*</sup>.

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    <p><sup>*</sup> Multivariable regression analysis controlled for the following variables: age, sex, race, household income, region of residence, urban or rural residence, osteoporosis, retinal vascular occlusion, sleep apnea, depression, diabetes mellitus, hypertension, myocardial infarction, cataract, hypotension, non-proliferative and proliferative diabetic retinopathy, pseudophakia/aphakia, and an interaction between sex and depression.</p><p><sup>^</sup> Reference group: non-Hispanic whites.</p><p><sup>†</sup> Reference group: <$30,000.</p><p><sup>♦</sup> risk reduction for every additional 1 month of medication consumption. For example, every additional 1 month use of bupropion is associated with a 0.6% reduced hazard of developing open-angle glaucoma.</p><p>HR, Hazard Ratio; CI, Confidence Interval; OAG, Open-Angle Glaucoma; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.</p><p>Multivariable analysis: risk factors for open-angle glaucoma<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123682#t003fn001" target="_blank"><sup>*</sup></a>.</p

    Hazard of developing open-angle glaucoma as a function of duration of bupropion use.

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    <p>Controlled for selective serotonin reuptake inhibitors, tricyclic antidepressant use, age, sex, race, income, region of residence, urban/rural residence, medical diseases (hypertension, hypotension, myocardial infarction, diabetes mellitus, sleep apnea, osteoarthritis, depression), ocular diseases (cataract extraction, diabetic retinopathy, retinal venous occlusive disease), and an interaction between sex and depression.</p><p>Hazard of developing open-angle glaucoma as a function of duration of bupropion use.</p
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