57 research outputs found

    Driving with Attention-Deficit/ Hyperactivity Disorder: Influences of Demand and Arousal in Real Traffic

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    Previous research has indicated a critical role of task demand in determining driving outcomes amongst individuals with attention-deficit/ hyperactivity disorder (ADHD). These findings are derived predominantly from laboratory simulations. The objective of the present study therefore was to investigate the relationship between factors influencing demand and arousal in real traffic, and the performance of drivers medicated (n = 15) and unmedicated for ADHD (n = 12), compared to a control group (n = 17). Self-reported data relating to risky driving behaviours and driving history, and symptoms of ADHD in adulthood were collected. To determine the influence of demand on driving performance and errors, participants navigated a route incorporating rural, urban, residential, and highway environments. Relative to controls, unmedicated ADHD drivers employed fewer safe driving skills (p < .05), committed more inattentive (p < .05), and impatient driving errors (p < .01), and reported engaging in more frequent aggressive violations (p < .05). ADHD was associated with higher rates of crashes (p < .01) and multiple crashes (p = .05). Attesting to the efficacy of stimulant treatment, medicated ADHD driver performance in the present study was comparable to, if not better than controls. While unmedicated drivers undervalued the risk related to driving behaviours predictive of poor outcomes, medicated ADHD drivers largely overestimated the severity of their risky driving (p < .01). Demand was found to significantly impact the performance of unmedicated ADHD drivers particularly. Attention was best during high demand, urban driving. As environmental demand declined, more frequent attentional lapses occasioned increased impairment to performance (p < .01). Relative to drivers of automatic vehicles, high demand manual driving was linked with better hazard detection (p < .05) and overall performance (p < .05) amongst medicated drivers, and safer following distances amongst unmedicated ADHD drivers (p < .05). Apparently distinct driving styles were also revealed between ADHD subtypes. This is the first study to document the impact of factors influencing task demand on ADHD driver performance in real traffic. Further exploration of the present findings could prove fundamental for future strategies of behavioural intervention

    “You’re Not the Police. You’re Providing a Library Service”: Reflections on Maintenance and Repair in/of Public Libraries During the COVID-19 Pandemic

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    This paper explores how services gaps between public libraries, governmental authorities, and other institutions were addressed during the COVID-19 pandemic and how the labor of filling these gaps reveals the repair and maintenance work in and on the public good of the library. The site for this exploration is the project Australian Public Libraries During the COVID-19 Crisis: Implications for Future Policy and Practice, which used mixed-methods questionnaires and interviews to understand the library and information science (LIS) profession’s response to the pandemic. During the pandemic, public institutions labored to maintain services and repair any gaps arising from disrupted services. The extraordinary labor instigated by the pandemic can be used to theorize the ordinary labor of maintaining public institutions such as libraries and how notions of the public good are reaffirmed through individual and institutional acts of care. The maintenance and repair of public libraries as institutions with community service obligations reveals assumptions about essential services, which communities are disadvantaged, and the policing role of libraries. Understanding the repair role of libraries helps researchers and practitioners to theorize and conceptualize their work and service to the community in new ways

    Searching for Programme theories for a realist evaluation: a case study comparing an academic database search and a simple Google search

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    Background: Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the first step in a realist evaluation or a realist synthesis, with literature reviews providing important evidence to support this. Deciding how to search for programme theories is challenging and there is limited guidance available. Using an example of identifying programme theories for a realist evaluation of Pressure Ulcer Risk Assessment Instruments in clinical practice, the authors explore and compare several different approaches to literature searching and highlight important methodological considerations for those embarking on a programme theory review. Methods: We compared the performance of an academic database search with a simple Google search and developed an optimised search strategy for the identification primary references (i.e. documents providing the clearest examples of programme theories) associated with the use of Pressure Ulcer Risk Assessment Instruments (PU-RAIs). We identified the number of primary references and the total number of references retrieved per source. We then calculated the number needed to read (NNR) expressed as the total number of titles and abstracts screened to identify one relevant reference from each source. Results: The academic database search (comprising CINAHL, The Cochrane Library, EMBASE, HMIC, Medline) identified 2 /10 primary references with a NNR of 1395.The Google search identified 7/10 primary references with a NNR of 10.1. The combined NNR was 286.3. The optimised search combining Google and CINAHL identified 10/10 primary references with a NNR of 40.2. Conclusion: The striking difference between the efficiency of the review’s academic database and Google searches in finding relevant references prompted an in-depth comparison of the two types of search. The findings indicate the importance of including grey literature sources such as Google in this particular programme theory search, while acknowledging the need for transparency of methods. Further research is needed to facilitate improved guidance for programme theory searches to enhance practice in the realist field and to save researcher time and therefore resource

    Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

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    The inability of neutrophils to eradicate Pseudomonas aeruginosa within the cystic fibrosis (CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of patients. Phagocytic killing of P. aeruginosa by CF neutrophils is impaired due to decreased cystic fibrosis transmembrane conductance regulator (CFTR) function and virulence factors acquired by the bacteria. Recently, neutrophil extracellular traps (NETs), extracellular structures composed of neutrophil chromatin complexed with granule contents, were identified as an alternative mechanism of pathogen killing. The hypothesis that NET-mediated killing of P. aeruginosa is impaired in the context of the CF airway was tested. P. aeruginosa induced NET formation by neutrophils from healthy donors in a bacterial density dependent fashion. When maintained in suspension through continuous rotation, P. aeruginosa became physically associated with NETs. Under these conditions, NETs were the predominant mechanism of killing, across a wide range of bacterial densities. Peripheral blood neutrophils isolated from CF patients demonstrated no impairment in NET formation or function against P. aeruginosa. However, isogenic clinical isolates of P. aeruginosa obtained from CF patients early and later in the course of infection demonstrated an acquired capacity to withstand NET-mediated killing in 8 of 9 isolates tested. This resistance correlated with development of the mucoid phenotype, but was not a direct result of the excess alginate production that is characteristic of mucoidy. Together, these results demonstrate that neutrophils can kill P. aeruginosa via NETs, and in vitro this response is most effective under non-stationary conditions with a low ratio of bacteria to neutrophils. NET-mediated killing is independent of CFTR function or bacterial opsonization. Failure of this response in the context of the CF airway may occur, in part, due to an acquired resistance against NET-mediated killing by CF strains of P. aeruginosa
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