Ambulatory Monitoring of Activities and Motor Symptoms in Parkinson's Disease

Ambulatory monitoring of motor symptoms in Parkinson's disease (PD) can improve our therapeutic strategies, especially in patients with motor fluctuations. Previously published monitors usually assess only one or a few basic aspects of the cardinal motor symptoms in a laboratory setting. We developed a novel ambulatory monitoring system that provides a complete motor assessment by simultaneously analyzing current motor activity of the patient (e.g., sitting, walking, etc.) and the severity of many aspects related to tremor, bradykinesia, and hypokinesia. The monitor consists of a set of four inertial sensors. Validity of our monitor was established in seven healthy controls and six PD patients treated with deep brain stimulation (DBS) of the subthalamic nucleus. The patients were tested at three different levels of DBS treatment. Subjects were monitored while performing different tasks, including motor tests of the Unified PD Rating Scale (UPDRS). Output of the monitor was compared to simultaneously recorded videos. The monitor proved very accurate in discriminating between several motor activities. Monitor output correlated well with blinded UPDRS ratings during different DBS levels. The combined analysis of motor activity and symptom severity by our PD monitor brings true ambulatory monitoring of a wide variety of motor symptoms one step close

A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin

Myopodin is an actin bundling protein that shuttles between nucleus and cytoplasm in response to cell stress or during differentiation. Here, we show that the myopodin sequence (58)KKRRRRARK(66), when tagged to either enhanced green fluorescent protein (EGFP) or to enhanced cyan fluorescent protein-CapG (ECFPCapG), is able to target these proteins to the nucleolus in HeLa or H-EK293T cells. By contrast, (KKRR61)-K-58 ECFP-CapG accumulates in the nucleus. Mutation of (58)KKRRRRARK(66) into alanine residues blocks myopodin nuclear import and promotes formation of cytoplasmic actin filaments. A second putative nuclear localization sequence, (612)KTSKKKGKK(620), displays much weaker activity in a heterologous context, and appears not to be functional in the full length protein. Thus myopodin nuclear translocation is dependent on a monopartite nuclear localization sequence

Interlace Polynomials for Multimatroids and Delta-Matroids

We provide a unified framework in which the interlace polynomial and several related graph polynomials are defined more generally for multimatroids and delta-matroids. Using combinatorial properties of multimatroids rather than graph-theoretical arguments, we find that various known results about these polynomials, including their recursive relations, are both more efficiently and more generally obtained. In addition, we obtain several interrelationships and results for polynomials on multimatroids and delta-matroids that correspond to new interrelationships and results for the corresponding graphs polynomials. As a tool we prove the equivalence of tight 3-matroids and delta-matroids closed under the operations of twist and loop complementation, called vf-safe delta-matroids. This result is of independent interest and related to the equivalence between tight 2-matroids and even delta-matroids observed by Bouchet.Comment: 35 pages, 3 figure

Nullity Invariance for Pivot and the Interlace Polynomial

We show that the effect of principal pivot transform on the nullity values of the principal submatrices of a given (square) matrix is described by the symmetric difference operator (for sets). We consider its consequences for graphs, and in particular generalize the recursive relation of the interlace polynomial and simplify its proof.Comment: small revision of Section 8 w.r.t. v2, 14 pages, 6 figure

The Group Structure of Pivot and Loop Complementation on Graphs and Set Systems

We study the interplay between principal pivot transform (pivot) and loop complementation for graphs. This is done by generalizing loop complementation (in addition to pivot) to set systems. We show that the operations together, when restricted to single vertices, form the permutation group S_3. This leads, e.g., to a normal form for sequences of pivots and loop complementation on graphs. The results have consequences for the operations of local complementation and edge complementation on simple graphs: an alternative proof of a classic result involving local and edge complementation is obtained, and the effect of sequences of local complementations on simple graphs is characterized.Comment: 21 pages, 7 figures, significant additions w.r.t. v3 are Thm 7 and Remark 2

Pivots, Determinants, and Perfect Matchings of Graphs

We give a characterization of the effect of sequences of pivot operations on a graph by relating it to determinants of adjacency matrices. This allows us to deduce that two sequences of pivot operations are equivalent iff they contain the same set S of vertices (modulo two). Moreover, given a set of vertices S, we characterize whether or not such a sequence using precisely the vertices of S exists. We also relate pivots to perfect matchings to obtain a graph-theoretical characterization. Finally, we consider graphs with self-loops to carry over the results to sequences containing both pivots and local complementation operations.Comment: 16 page

Prospectie met ingreep in de bodem aan de Kerkbossenstraat in Heist-op-den-Berg

Dit rapport werd ingediend bij het agentschap samen met een aantal afzonderlijke digitale bijlagen. Een aantal van deze bijlagen zijn niet inbegrepen in dit pdf document en zijn niet online beschikbaar. Sommige bijlagen (grondplannen, fotos, spoorbeschrijvingen, enz.) kunnen van belang zijn voor een betere lezing en interpretatie van dit rapport. Indien u deze bijlagen wenst te raadplegen kan u daarvoor contact opnemen met: [email protected]

Prospectie met ingreep in de bodem aan de Albert Sohiestraat in Oud-Turnhout

Dit rapport werd ingediend bij het agentschap samen met een aantal afzonderlijke digitale bijlagen. Een aantal van deze bijlagen zijn niet inbegrepen in dit pdf document en zijn niet online beschikbaar. Sommige bijlagen (grondplannen, fotos, spoorbeschrijvingen, enz.) kunnen van belang zijn voor een betere lezing en interpretatie van dit rapport. Indien u deze bijlagen wenst te raadplegen kan u daarvoor contact opnemen met: [email protected]