Optimal Location Design for Prediction of Spatial Correlated Environmental Functional Data

The optimal choice of sites to make spatial prediction is critical for a better understanding of really spatio-temporal data. It is important to obtain the essential spatio-temporal variability of the process in determining optimal design, because these data tend to exhibit both spatial and temporal variability. Two new methods of prediction for spatially correlated functional data are considered. The first method models spatial dependency by fitting variogram to empirical variogram, similar to ordinary kriging (univariate approach). The second method models spatial dependency by linear model co-regionalization (multivariate approach). The variance of prediction method was chosen as the optimization design criterion. An application to CO concentration forecasting was conducted to examine possible differences between the design and the optimal design without considering temporal structure

Multi-objective green supply chain optimization with a new hybrid memetic algorithm using the Taguchi method

AbstractThe aim of most supply chain optimization problems is to minimize the total cost of the supply chain. However, since environmental protection is of concern to the public, a green supply chain, because of its minimum effect on nature, has been seriously considered as a solution to this concern. This paper addresses the modeling and solving of a supply chain design for annual cost minimization, while considering environmental effects. This paper considers the cost elements of the supply chain, such as transportation, holding and backorder costs, and also, the environmental effect components of the supply chain, such as the amount of NO2, CO and volatile organic particles produced by facilities and transportation in the supply chain. Considering these two components (cost and environmental effects), we propose a multi-objective optimization problem. In this model, the facilities and transportation options have a capacity constraint and, at each level of the chain, we have several transportation options with different costs. We utilize a memetic algorithm in combination with the Taguchi method to solve this complex model. We also propose a novel decoding method and priority based algorithm for coding the solution chromosome. The performance of the proposed solution method has been examined against the hybrid genetic Taguchi algorithm (GATA) on a set of numeric instances, and results indicate that the proposed method can effectively provide better results than previous solution procedures

Using continuous wavelet transform of generalized flexibility matrix in damage identification

Generalized flexibility matrix method has recently been introduced for identifying damages with the aim of overcoming some shortcomings of the approaches based on flexibility matrix. Researchers that use flexibility matrix to detect damages in structures face truncation errors ensue from cut off higher-order mode shapes, which are difficult to measure in practice. In this paper, a new procedure is presented to detect the damage site in a beam-type structure, where generalized flexibility matrix in conjunction with continuous wavelet transform (CWT) is utilized. Since flaws and cracks cause changes in flexibility of a system, this characteristic can be used as a damage indicator. Gaussian wavelet transform with four vanishing moments as a signal processing method is implemented to find the irregularity in a vector obtained from generalized flexibility matrix which is considered as a sign of damage. This method does not need to have either prior knowledge about the intact structure or its finite element model. The proposed technique is evaluated by numerical and experimental case studies

Исследование влияния технологического процесса изготовления обмоток на дефектность корпусной изоляции асинхронных двигателей

В работе проведено исследование влияния колебаний режимов работы статорообмоточных станков WST-660 и пазоизолировочных станков ИПС-3 на дефектность корпусной изоляции. Получены математические модели дефектообразования в корпусной изоляции обмотки с учетом режимов работы технологического оборудования и качества материала корпусной изоляции в состоянии поставки. Установлено, что изменением режимов работы технологического оборудования можно добиться требуемого качества корпусной изоляции при максимальной производительности оборудования

Disseminated Leishmaniasis Caused by Leishmania tropica in a Puppy from Karaj, Central Iran

A 5-month old puppy with muco-cutaneous lesions in the chin, around lips and eyes was examined physically and microscopically for leishmaniasis. Muco-cutaneous lesions containing a large number of amastigotes of Leishmania spp. were observed. Amastigotes were also detected in liver and spleen of the puppy. The animal was positive with Dipstick rK39 kit and high level of anti-Leishmania antibodies was detected by direct agglutination test (DAT). DNA, Using PCR-RFLP technique extracted from cultured Leishmania promastigotes and L. tropica was identified. This is the first report of concurrent mucosal and visceral involvement of L. tropica in a puppy from Iran

Effects of systematic shortening of noncovalent C8 side chain on the cytotoxicity and NF-κB inhibitory capacity of pyrrolobenzodiazepines (PBDs)

The systematic shortening of the noncovalent element of a C8-linked pyrrolobenzodiazepine (PBD) conjugate (13) led to the synthesis of a 19-member library of C8-PBD monomers. The critical elements of 13, which were required to render the molecule cytotoxic, were elucidated by an annexin V assay. The effects of shortening the noncovalent element of the molecule on transcription factor inhibitory capacity were also explored through an enzyme-linked immunosorbent assay-based measurement of nuclear NF-κB upon exposure of JJN-3 cells to the synthesized molecules. Although shortening the noncovalent interactive element of 13 had a less than expected effect upon compound cytotoxicity due to reduced DNA interaction, the transcription factor inhibitory capacity of the molecule was notably altered. This study suggests that a relatively short noncovalent side chain at the C8 position of PBD is sufficient to confer cytotoxicity. The shortened PBD monomers provide a new ADC payload scaffold because of their potent cytotoxicity and druglike properties

Preparação da Liga Amorfa Co72Nb24B4 como Catalisador na Reação de Oxidação do Metanol

This study aims to investigate and characterize the amorphous alloy Co72Nb24B4 the catalytic oxidation of methanol in products that serve as primary reagents for organic synthesis, such as formaldehyde and other intermediate products. The technique for obtaining the amorphous alloy was electric arc smelting furnace. The amorphous alloy catalyst Co72Nb24B4 was characterized by XRD, SEM / EDS, BET and thermal analysis TGA and DTA. The objective of this work is to develop and study the application of amorphous alloy as catalysts and catalyst supports, due to its thick this oxide layer on its surface capable of oxidizing methanol and intermediates of methanol oxidation reaction. The amorphous alloy structure Co72Nb24B4 is still stable after the catalytic test, since the formation of intermetallic and amorphous phases are rich in active sites that are important for the catalytic processes at the surface of these amorphous materials. DOI: http://dx.doi.org/10.17807/orbital.v7i4.76