The time resolved measurement of ultrashort THz-band electric fields without an ultrashort probe

The time-resolved detection of ultrashort pulsed THz-band electric field temporal profiles without an ultrashort laser probe is demonstrated. A non-linear interaction between a narrow-bandwidth optical probe and the THz pulse transposes the THz spectral intensity and phase information to the optical region, thereby generating an optical pulse whose temporal electric field envelope replicates the temporal profile of the real THz electric field. This optical envelope is characterised via an autocorrelation based FROG measurement, hence revealing the THz temporal profile. The combination of a narrow-bandwidth, long duration, optical probe and self-referenced FROG makes the technique inherently immune to timing jitter between the optical probe and THz pulse, and may find particular application where the THz field is not initially generated via ultrashort laser methods, such as the measurement of longitudinal electron bunch profiles in particle accelerators.Comment: 7 pages, 3 figures, submitted to AP

Electro-optic bunch diagnostics on ALICE

An electro-optic longitudinal bunch profile monitor has been implemented on ALICE (Accelerators and Lasers in Combined Experiments) at the Daresbury Laboratories and will be used both to characterise the electron bunch and to provide a testbed for electro-optic techniques. The electro-optic station is located immediately after the bunch compressor, within the FEL cavity; its location allows nearby OTR, beam profile monitors and Coherent Synchrontron Radiation (CSR) diagnostics to be used for calibration and benchmarking. We discuss the implementation and the planned studies on electro-optic diagnostics using this diagnostic station

Upconversion of a relativistic Coulomb field terahertz pulse to the near infrared

We demonstrate the spectral upconversion of a unipolar subpicosecond terahertz (THz) pulse, where the THz pulse is the Coulomb field of a single relativistic electron bunch. The upconversion to the optical allows remotely located detection of long wavelength and nonpropagating components of the THz spectrum, as required for ultrafast electron bunch diagnostics. The upconversion of quasimonochromatic THz radiation has also been demonstrated, allowing the observation of distinct sum- and difference-frequency mixing components in the spectrum. Polarization dependence of first and second order sidebands at ωopt±ωTHz, and ωopt±2ωTHz, respectively, confirms the χ(2) frequency mixing mechanism

NF-κB activation protects oligodendrocytes against inflammation

NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, the effects of NF-κB activation on oligodendrocytes in MS and EAE remain unknown. We generated a mouse model that expresses IκBαΔN, a super-suppressor of NF-κB, specifically in oligodendrocytes and demonstrated that IκBαΔN expression had no effect on oligodendrocytes under normal conditions (both sexes). Interestingly, we showed that oligodendrocyte-specific expression of IκBαΔN blocked NF-κB activation in oligodendrocytes and resulted in exacerbated oligodendrocyte death and hypomyelination in young, developing mice that ectopically express IFN-γ in the CNS (both sexes). We also showed that NF-κB inactivation in oligodendrocytes aggravated IFN-γ-induced remyelinating oligodendrocyte death and remyelination failure in the cuprizone model (male mice). Moreover, we found that NF-κB inactivation in oligodendrocytes increased the susceptibility of mice to EAE (female mice). These findings imply the cytoprotective effects of NF-κB activation on oligodendrocytes in MS and EAE

Longtitudinal electron beam diagnostics via upconversion of THz to visible radiation

Longitudinal electro-optic electron bunch diagnostics has been successfully applied at several accelerators. The electro-optic effect can be seen as an upconversion of the Coulomb field of the relativistic electron bunch (THz radiation) to the visible spectral range, where a variety of standard diagnostic tools are available. Standard techniques to characterise femtosecond optical laser pulses (auto- and cross-correlators) have led to the schemes that can measure electron bunch profiles with femtosecond resolution. These techniques require, however, well synchronized femtosecond laser pulses, in order to obtain the desired temporal resolution. Currently, we are exploring other electro-optic variants which require less advanced laser systems and will be more amenable to beam based longitudinal feedback applications. The first results of one such new scheme will be presented in this paper

A Multiple-Objective Decision Analysis of Stakeholder Values to Identify Watershed Improvement Needs

The paper describes the use of multiple objective decision analysis to qualitatively and quantitatively assess the quality of an endangered watershed and guide future efforts to improve the quality of the watershed. The Upham Brook watershed is an urban watershed that lies at the interface of declining inner city Richmond, Virginia and growth-oriented Henrico County. A section of stream within the watershed has been identified as so dangerously polluted that it threatens the health of the residents who live within the watershed boundaries. With funding provided by the National Science Foundation, the Upham Brook watershed project committee was formed to address the quality of the Upham Brook watershed; it consisted of experts from multiple disciplines: stream ecology, environmental policy, water policy, ground and surface water hydrology and quality, aquatic biology, political science, sociology, citizen participation, community interaction, psychology, and decision and risk analysis. Each members\u27 values and goals were brought together using a watershed management framework to meet the overall objective of the committee: to maximize the quality of the Upham Brook watershed. The resulting model was used to identify the largest value gaps and to identify future programs needed to improve the quality of the watershed

Electro-optic techniques for longitudinal electron bunch diagnostics

Electro-optic techniques are becoming increasingly important in ultrafast electron bunch longitudinal diagnostics and have been successfully implemented at various accelerator laboratories. The longitudinal bunch shape is directly obtained from a single-shot, non-intrusive measurement of the temporal electric field profile of the bunch. Further- more, the same electro-optic techniques can be used to measure the temporal profile of terahertz / far-infrared opti- cal pulses generated by a CTR screen, at a bending magnet (CSR), or by an FEL. This contribution summarizes the re- sults obtained at FELIX and FLASH

Dynamics of Feshbach Molecules in an Ultracold Three-Component Mixture

We present investigations of the formation rate and collisional stability of lithium Feshbach molecules in an ultracold three-component mixture composed of two resonantly interacting fermionic 6-Li spin states and bosonic 174-Yb. We observe long molecule lifetimes (> 100 ms) even in the presence of a large ytterbium bath and extract reaction rate coefficients of the system. We find good collisional stability of the mixture in the unitary regime, opening new possibilities for studies and probes of strongly interacting quantum gases in contact with a bath species.Comment: 5 pages, 3 figure