Identification of Clinically Relevant Regions of the Human \u3ci\u3eCDH1\u3c/i\u3e Gene for Determining Predisposition to Hereditary Diffuse Gastric Cancer

Genetic testing has opened new doors into understanding a patient’s future health. The human genome is extremely vast and complicated. Testing an entire genome for the innumerable genetic variants that have a bearing on the development of cancer is costly both in time25 and efficiency. Testing for just a single gene results in seeing a whole group of variations, which may or may not be pathogenic11. Pathogenic, in this case, is defined as a variant known to cause or increase risk of a disease, the degree of which is determined by how co-segregated it is with the disease16,17. One of the genes that is examined when looking at hereditary diffuse gastric cancer (HDGC) often is Cadherin-1, or CDH1

Techno-futurism and the knowledge economy in New Zealand

This thesis analyses the material and ideological dimensions of the knowledge economy with particular reference to New Zealand. The emergence of the new information and communication technologies (ICTs) in the context of transnational capitalism precipitates the co modification of information, communication and knowledge. This process is obscured by the ideological construction of techno-futurism. Techno-futurism is a combination of technological determinism and futurism that appropriates notions of progress. In the pages which follow, historical analyses of this ideology inform the subsequent critique of knowledge economy discourse. In New Zealand knowledge economy discourse contained techno-futurist elements and deflected attention from the global absorption of national capitalism. In this context the Catching the Knowledge Wave Conference (KWC), held in Auckland in the first days of August 2001, is examined. I argue that the instigators and organisers of the conference were enmeshed within the business culture of finance capital and ICTs. Textual analysis of keynote addresses reveals the ideological dimensions to knowledge wave and knowledge economy talk. These dimensions are; entrepreneurialism, knowledge as (economic) progress, and globalism

Extraction of blade-vortex interactions from helicopter transient maneuvering noise

textTime-frequency analysis techniques are proposed as a necessary tool for the analysis of acoustics generated by helicopter transient maneuvering flight. Such techniques are necessary as the acoustic signals related to transient maneuvers are inherently unsteady. The wavelet transform is proposed as an appropriate tool, and it is compared to the more standard short-time Fourier transform technique through an investigation using several appropriately sized interrogation windows. It is shown that the wavelet transform provides a consistent spectral representation, regardless of employed window size. The short-time Fourier transform, however, provides spectral amplitudes that are highly dependent on the size of the interrogation window, and so is not an appropriate tool for this situation. An extraction method is also proposed to investigate blade-vortex interaction noise emitted during helicopter transient maneuvering flight. The extraction method allows for the investigation of blade-vortex interactions independent of other sound sources. The method is based on filtering the spectral data calculated through the wavelet transform technique. The filter identifies blade-vortex interactions through their high amplitude, high frequency impulsive content. The filtered wavelet coefficients are then inverse transformed to create a pressure signature solely related to blade-vortex interactions. This extraction technique, along with a prescribed wake model, is applied to experimental data extracted from three separate flight maneuvers performed by a Bell 430 helicopter. The maneuvers investigated include a steady level flight, fast- and medium-speed advancing side roll maneuvers. A sensitivity analysis is performed in order to determine the optimal tuning parameters employed by the filtering technique. For the cases studied, the optimized tuning parameters were shown to be frequencies above 7 main rotor harmonics, and amplitudes stronger than 25% (−6 dB) of the energy in the main rotor harmonic. Further, it is shown that blade-vortex interactions can be accurately extracted so long as the blade-vortex interaction peak energy signal is greater or equal to the energy in the main rotor harmonic. An in-depth investigation of the changes in the blade-vortex interaction signal during transient advancing side roll maneuvers is then conducted. It is shown that the sound pressure level related to blade-vortex interactions, shifts from the advancing side, to the retreating side of the vehicle during roll entry. This shift is predicted adequately by the prescribed wake model. However, the prescribed wake model is shown to be inadequate for the prediction of blade-vortex interaction miss distance, as it does not respond to the roll rate of the vehicle. It is further shown that the sound pressure levels are positively linked to the roll rate of the vehicle. Similar sound pressure level directivities and amplitudes can be seen when vehicle roll rates are comparable. The extraction method is shown to perform admirably throughout each maneuver. One limitation with the technique is identified, and a proposal to mitigate its effects is made. The limitation occurs when the main rotor harmonic energy drops below an arbitrary threshold. When this happens, a decreased spectral amplitude is required for filtering; which leads to the extraction of high frequency noise unrelated to blade-vortex interactions. It is shown, however, that this occurs only when there are no blade-vortex interactions present. Further, the resulting sound pressure level is identifiable as it is significantly less than the peak blade-vortex interaction sound pressure level. Thus the effects of this limitation are shown to be negligible.Aerospace Engineerin

Lateral-directional stability and control characteristics of the Quiet Short-Haul Research Aircraft (QSRA)

The results are presented of flight experiments to determine the lateral-directional stability and control characteristics of the Quiet Short-Haul Research Aircraft (QSRA), an experimental aircraft designed to furnish information on various aerodynamic characteristics of a transport type of airplane that makes use of the upper-surface blown (USB) flap technology to achieve short takeoff and landing (STOL) performance. The flight program designed to acquire the data consisted of maneuvers produced by rudder and control-wheel inputs with the airplane in several configurations that had been proposed for landing approach and takeoff operation. The normal stability augmentation system was not engaged during these maneuvers. Time-history records from the maneuvers were analyzed with a parameter estimation procedure to extract lateral-directional stability and control derivatives. For one aircraft configuration in which the USB flaps were deflected 50 deg, several maneuvers were performed to determine the effects of varying the average angle of attack, varying the thrust coefficient, and setting the airplane's upper surface spoilers at a 13 deg symmetrical bias angle . The effects on the lateral characteristics of deflecting the spoilers were rather small and generally favorable. The data indicate that for one test, conducted at low thrust (a thrust coefficient of 0.38), compared with results from tests at thrust coefficients of 0.77 and larger, there was a significant decrease in the lateral control effectiveness, in the yaw damping and in the directional derivative. The directional derivative was also decreased (by about 30 percent) when the average angle of attack of the test was increased from 3 to 16 deg