697 research outputs found

    Alien Registration- Mcmurray, James A. (Millinocket, Penobscot County)

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    https://digitalmaine.com/alien_docs/7769/thumbnail.jp

    The Beach Ballet

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    http://deepblue.lib.umich.edu/bitstream/2027.42/120339/1/McCurray_TheBeachBallet.pd

    Letter From the Editor

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    http://deepblue.lib.umich.edu/bitstream/2027.42/120334/1/JamesMcMurray_EditorLetter.pd

    Mobile work platform for initial lunar base construction

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    Described is a system of equipment intended for site preparation and construction of a lunar base. The proximate era of lunar exploration and the initial phase of outpost habitation are addressed. Drilling, leveling, trenching, and cargo handling are within the scope of the system's capabilities. The centerpiece is a three-legged mobile work platform, named SKITTER. Using standard interfaces, the system is modular in nature and analogous to the farmer's tractor and implement set. Conceptually somewhat different from their Earthbound counterparts, the implements are designed to take advantage of the lunar environment as well as the capabilities of the work platform. The proposed system is mechanically simple and weight efficient

    Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial

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    Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction. Background: Many patients with type 2 diabetes mellitus have heart failure and it is important to know about the safety of new treatments for diabetes in these individuals. Methods: Patients 18 to 85 years of age with type 2 diabetes and heart failure (New York Heart Association functional class I to III and left ventricular ejection fraction [LVEF] <0.40) were randomized to 52 weeks treatment with vildagliptin 50 mg twice daily (50 mg once daily if treated with a sulfonylurea) or matching placebo. The primary endpoint was between-treatment change from baseline in echocardiographic LVEF using a noninferiority margin of −3.5%. Results: A total of 254 patients were randomly assigned to vildagliptin (n = 128) or placebo (n = 126). Baseline LVEF was 30.6 ± 6.8% in the vildagliptin group and 29.6 ± 7.7% in the placebo group. The adjusted mean change in LVEF was 4.95 ± 1.25% in vildagliptin treated patients and 4.33 ± 1.23% in placebo treated patients, a difference of 0.62 (95% confidence interval [CI]: −2.21 to 3.44; p = 0.667). This difference met the predefined noninferiority margin of −3.5%. Left ventricular end-diastolic and end-systolic volumes increased more in the vildagliptin group by 17.1 ml (95% CI: 4.6 to 29.5 ml; p = 0.007) and 9.4 ml (95% CI: −0.49 to 19.4 ml; p = 0.062), respectively. Decrease in hemoglobin A1c from baseline to 16 weeks, the main secondary endpoint, was greater in the vildagliptin group: −0.62% (95% CI: −0.93 to −0.30%; p < 0.001; −6.8 mmol/mol; 95% CI: −10.2 to −3.3 mmol/mol). Conclusions: Compared with placebo, vildagliptin had no major effect on LVEF but did lead to an increase in left ventricular volumes, the cause and clinical significance of which is unknown. More evidence is needed regarding the safety of dipeptidyl peptidase-4 inhibitors in patients with heart failure and left ventricular systolic dysfunction. (Effect of Vildagliptin on Left Ventricular Function in Patients With Type 2 Diabetes and Congestive Heart Failure; NCT00894868

    Network analysis reveals open forums and echo chambers in social media discussions of climate change

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    Open Access articleAction to tackle the complex and divisive issue of climate change will be strongly influenced by public perception. Online social media and associated social networks are an increasingly important forum for public debate and are known to influence individual attitudes and behaviours yet online discussions and social networks related to climate change are not well understood. Here we construct several forms of social network for users communicating about climate change on the popular microblogging platform Twitter. We classify user attitudes to climate change based on message content and nd that social networks are characterised by strong attitude-based homophily and segregation into polarised "sceptic" and "activist" groups. Most users interact only with like-minded others, in communities dominated by a single view. However, we also nd mixed-attitude communities in which sceptics and activists frequently interact. Messages between like-minded users typically carry positive sentiment, while messages between sceptics and activists carry negative sentiment. We identify a number of general patterns in user behaviours relating to engagement with alternative views. Users who express negative sentiment are themselves the target of negativity. Users in mixed- attitude communities are less likely to hold a strongly polarised view, but more likely to express negative sentiment towards other users with di ering views. Overall, social media discussions of climate change often occur within polarising "echo chambers", but also within "open forums", mixed-attitude communities that reduce polarisation and stimulate debate. Our results have implications for public engagement with this important global challenge.Engineering and Physical Sciences Research Council (EPSRC) - Bridging the Gaps initiativ

    Kinetics of corrosion-driven cathodic disbondment on organic coated trivalent chromium metal-oxide-carbide coatings on steel

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    Chromium metal-oxide-carbide coatings of varying composition and thickness, cathodically electrodeposited from a Cr (III)-formate electrolyte are compared for their ability to resist the corrosion driven delamination of an adherent polymer overcoat. Cathodic disbondment rates are determined using an in-situ scanning Kelvin probe technique. The rates of cathodic disbondment decreased with increasing thickness and Cr (III) oxide content of the Cr (III) derived coating. Disbondment kinetics are explained in terms of coating porosity, chemical composition and electrocatalytic activity of the various metallic surfaces for the cathodic oxygen reduction reaction (ORR). Diminished electrocatalytic activity for ORR, as determined from cathodic polarisation measurements with a rotating disk electrode, are found to correlate with diminished delamination kinetics
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