The role of DNA methylation on gene expression in actue lymphoblastic leukemia

Epigenetic modification of the genome has more influence on gene expression than DNA sequence alone. DNA hypermethylation and deacetylation of histone complexes has been shown to down regulate expression of associated genes. These epigenetic modifications may play an important role in the pathogenesis of cancer. Demethylation agents and histone deacytlase inhibitors used to restore gene activity to previous levels could lead to development of novel anti-cancer drugs."NIH K99CA132784 (K. H. Taylor)

Log book of schooner 'Malcolm' 1882 Index: Royal Society Collection

Log book of schooner 'Malcolm', master Walter Langworthy. An official printed form Board of Trade log book, but it contains no entries except a list of crew and a report of the death of the First Mate, James Roper, from a fall at Port Jackson. RS.8

Review: The Journal of Dramaturgy, volume 22, issue 2

Contents include: Editor\u27s Note; Elliott Hayes Award Acceptance Speech From Denver to Gulu, With Thanks to Lynn Nottage; Learning to Speak American: A Writer\u27s Journey, Keynote Remarks Delivered at the Annual Conference of the Literary Managers and Dramturgs of the Americas, Alliance Theatre, Atlanta, GA June 28, 2012; Michael Mark Chemers\u27 Ghost Light: An Introductory Handbook for Dramaturgy; Creative Process in Theatrical Translation: An Interview with Adam Versenyi; Croisades in Quebec: On the Semiotics of Contemporary French Dramaturgie. Issue editors: Sydney Cheek-O\u27Donnell, Debra Cardona, Janine Sobeckhttps://soundideas.pugetsound.edu/lmdareview/1044/thumbnail.jp

A Tunguska Sized Airburst Destroyed Tall el‑Hammam a Middle Bronze Age City in the Jordan Valley Near the Dead Sea

We present evidence that in ~ 1650 BCE (~ 3600 years ago), a cosmic airburst destroyed Tall el-Hammam, a Middle-Bronze-Age city in the southern Jordan Valley northeast of the Dead Sea. The proposed airburst was larger than the 1908 explosion over Tunguska, Russia, where a ~ 50-m-wide bolide detonated with ~ 1000× more energy than the Hiroshima atomic bomb. A city-wide ~ 1.5-m-thick carbon-and-ash-rich destruction layer contains peak concentrations of shocked quartz (~ 5–10 GPa); melted pottery and mudbricks; diamond-like carbon; soot; Fe- and Si-rich spherules; CaCO(3) spherules from melted plaster; and melted platinum, iridium, nickel, gold, silver, zircon, chromite, and quartz. Heating experiments indicate temperatures exceeded 2000 °C. Amid city-side devastation, the airburst demolished 12+ m of the 4-to-5-story palace complex and the massive 4-m-thick mudbrick rampart, while causing extreme disarticulation and skeletal fragmentation in nearby humans. An airburst-related influx of salt (~ 4 wt.%) produced hypersalinity, inhibited agriculture, and caused a ~ 300–600-year-long abandonment of ~ 120 regional settlements within a > 25-km radius. Tall el-Hammam may be the second oldest city/town destroyed by a cosmic airburst/impact, after Abu Hureyra, Syria, and possibly the earliest site with an oral tradition that was written down (Genesis). Tunguska-scale airbursts can devastate entire cities/regions and thus, pose a severe modern-day hazard

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

The prefrontal cortex is a critical neuroanatomical hub for controlling motivated behaviours across mammalian species. In addition to intra-cortical connectivity, prefrontal projection neurons innervate subcortical structures that contribute to reward-seeking behaviours, such as the ventral striatum and midline thalamus. While connectivity among these structures contributes to appetitive behaviours, how projection-specific prefrontal neurons encode reward-relevant information to guide reward seeking is unknown. Here we use in vivo two-photon calcium imaging to monitor the activity of dorsomedial prefrontal neurons in mice during an appetitive Pavlovian conditioning task. At the population level, these neurons display diverse activity patterns during the presentation of reward-predictive cues. However, recordings from prefrontal neurons with resolved projection targets reveal that individual corticostriatal neurons show response tuning to reward-predictive cues, such that excitatory cue responses are amplified across learning. By contrast, corticothalamic neurons gradually develop new, primarily inhibitory responses to reward-predictive cues across learning. Furthermore, bidirectional optogenetic manipulation of these neurons reveals that stimulation of corticostriatal neurons promotes conditioned reward-seeking behaviour after learning, while activity in corticothalamic neurons suppresses both the acquisition and expression of conditioned reward seeking. These data show how prefrontal circuitry can dynamically control reward-seeking behaviour through the opposing activities of projection-specific cell populations

Review of the Department of Natural Resources Parks Reservation System and the Electronic Licensing System for Iowa for the period July 1, 2006 through June 30, 2011

Review of the Department of Natural Resources Parks Reservation System and the Electronic Licensing System for Iowa for the period July 1, 2006 through June 30, 201