17 research outputs found
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Novel Coronavirus and Orthopaedic Surgery Early Experiences from Singapore
10.2106/JBJS.20.00236JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME1029745-74
Postoperative Evaluation of the Knee after Autologous Chondrocyte Implantation: What Radiologists Need to Know
COVID-19 and Pediatric Orthopaedics: What's Different?
10.1097/BPO.0000000000001575JOURNAL OF PEDIATRIC ORTHOPAEDICS406E402-E40
Osteochondral tissue engineering: Perspectives for clinical application and preclinical development
10.1016/j.jot.2021.07.008Journal of Orthopaedic Translation3093-10
Cellular senescence in aging and osteoarthritis: Implications for cartilage repair
It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation. In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population
Human mesenchymal stem cell-derived exosomes promote orderly cartilage regeneration in an immunocompetent rat osteochondral defect model
Effects of Ectopic Nanog and Oct4 overexpression on mesenchymal stem cells
10.1089/scd.2008.0335Stem Cells and Development1871013-102
Repair of Osteochondral Defects with Rehydrated Freeze-Dried Oligo[Poly(Ethylene Glycol) Fumarate] Hydrogels Seeded with Bone Marrow Mesenchymal Stem Cells in a Porcine Model
Current surgical techniques for osteochondral injuries in young active patients are inadequate clinically. Novel
strategies in tissue engineering are continuously explored in this area. Despite numerous animal studies that have
shown encouraging results, very few large-scale clinical trials have been done to address this area of interest. To
facilitate the eventual translation from rabbit to human subjects, we have performed a study using bone marrowderived
mesenchymal stem cell (BMSC)ヨoligo[poly(ethylene glycol) fumarate] (OPF) hydrogel scaffold in a porcine
model. Our objective was to analyze the morphology of BMSCs seeded into rehydrated freeze-dried OPF hydrogel
and in vivo gross morphological and histological outcome of defects implanted with the BMSCs-OPF scaffold in a
porcine model. The analyses were based on magnified histologic sections for different types of cartilage repair
tissues, the outcome of the subchondral bone, scaffold, and statistical assessment of neotissue-filling percentage,
cartilage phenotype, and Wakitani scores. The morphology of the BMSCs seeded into the rehydrated freeze-dried
OPF scaffold was observed 24 h after cell seeding, through the phase-contrast microscope. The three-dimensional
and cross-sectional structure of the fabrication was analyzed through confocal microscopy and histological
methods, respectively. The BMSCs remained viable and were condensed into many pellet-like cell masses with a
diameter ranging from 28.5 to 298.4 (113.5 - 47.9) mm in the OPF scaffold. In vivo osteochondral defect repair was
tested in 12 defects created in six 8-month-old Prestige World Genetics micropigs. The implantation of scaffold
alone was used for control. Gross morphological, histological, and statistical analyses were performed at 4 months
postoperatively. The scaffoldヨMSC treatment led to 99% defect filling, with 84% hyaline-like cartilage at 4 months,
which was significantly ( p < 0.0001) more than the 54% neotissue filling and 39% hyaline-like cartilage obtained in
the scaffold-only group. The implantation of BMSCs in freeze-dried OPF hydrogel scaffold, which created a
conducive environment for cell infiltration and clustering, could fully repair chondral defects with hyaline-like
cartilage. This protocol provides a clinically feasible procedure for osteochondral defect treatment