John Adams and the Diplomacy of the American Revolution

The figure of John Adams looms large in American foreign relations of the Revolutionary and post-Revolutionary years. James H. Hutson captures this elusive personality of this remarkable figure, highlighting the triumphs and the despairs that Adams experienced as he sought—at times, he felt, single-handedly—to establish the new Republic on a solid footing among the nations of the world. Benjamin Franklin, thirty years Adams’s senior and already a world-respected figure, was his personal nemesis, seeming always to dog his steps in his diplomatic missions. The diplomacy of the American Revolution as exemplified by John Adams was not radically revolutionary or peculiarly American. Whereas the prevailing progressive interpretation of Revolutionary diplomacy sees it as repudiating the standard European theories and practices, Hutson finds that Adams adhered consistently to a policy that was in fact basically European and conservative. Adams assumed—as did his contemporaries—that power was aggressive and that it should be contained in a balance, so his actions while in diplomatic service were generally directed toward this goal. Adams’s basic ideas survived his turbulent diplomatic missions with undiminished coherence. For him the value of the protective system of the balance of power—having been tested in the harsh theater of European diplomacy—was indisputable and could be applied to domestic political arrangements as well as to international relations. James H. Hutson is supervisory librarian at the Library of Congress. He has taught history at Yale University and served as assistant editor of The Papers of Benjamin Franklin.https://uknowledge.uky.edu/upk_diplomatic_history/1003/thumbnail.jp

Immigrant Workers in the Massachusetts Health Care Industry: A Report on Status and Future Prospects

Given the vital picture of foreign-born health care workers, this study has the following objectives: To document the labor market position of foreign-born workers in the sector at various levels (national, statewide, sub-regional) including patterns of occupational concentration during the last decade or so, prospects for occupational mobility, wages, geographic concentration, employment by type of establishment (hospitals, community health centers, etc.) and workforce development opportunities; To document, whenever possible, the socio-economic and demographic characteristics of foreign-born workers in the sector, including country of origin and gender among others; To document the qualitative contribution of foreign-born workers in the health care delivery environment, especially through cultural and linguistic competence as well as cross cultural communications; To document promising institutional practices in Massachusetts (mainly collaborations and workforce development activities) aimed at improving or modifying the conditions for foreign-born workers and enhancing the labor pool for employers; To document the important role that institutions (universities, research organizations, hospitals, unions and professional associations, government and the non-profit sector) play in shaping the labor market prospects of foreign-born workers in the health care sector; To document critical shortages in some health care professions and occupations; To outline public policy recommendations for broad dissemination

Immigrant Workers in the Massachusetts Health Care Industry: A Report on Status and Future Prospects

Given the vital picture of foreign-born health care workers, this study has the following objectives: To document the labor market position of foreign-born workers in the sector at various levels (national, statewide, sub-regional) including patterns of occupational concentration during the last decade or so, prospects for occupational mobility, wages, geographic concentration, employment by type of establishment (hospitals, community health centers, etc.) and workforce development opportunities; To document, whenever possible, the socio-economic and demographic characteristics of foreign-born workers in the sector, including country of origin and gender among others; To document the qualitative contribution of foreign-born workers in the health care delivery environment, especially through cultural and linguistic competence as well as cross cultural communications; To document promising institutional practices in Massachusetts (mainly collaborations and workforce development activities) aimed at improving or modifying the conditions for foreign-born workers and enhancing the labor pool for employers; To document the important role that institutions (universities, research organizations, hospitals, unions and professional associations, government and the non-profit sector) play in shaping the labor market prospects of foreign-born workers in the health care sector; To document critical shortages in some health care professions and occupations; To outline public policy recommendations for broad dissemination

Randomized, Double-Blind, Placebo-Controlled Phase III Study of Tasquinimod in Men With Metastatic Castration-Resistant Prostate Cancer

PURPOSE: Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival (PFS) in a randomized, placebo-controlled phase II trial in men with metastatic castration-resistant prostate cancer (mCRPC). This phase III study was conducted to confirm the phase II results and to detect an overall survival (OS) benefit. PATIENTS AND METHODS: Men with chemotherapy-naïve mCRPC and evidence of bone metastases were assigned (2:1) to receive tasquinimod once per day or placebo until progression or toxicity. The primary end point was radiographic PFS (rPFS; time from random assignment to radiologic progression or death) per Prostate Cancer Working Group 2 criteria and RECIST 1.1. The study had 99.9% power to detect an rPFS hazard ratio (HR) of 0.6 with a two-sided alpha error of .05 and 80% power to detect a target HR of 0.8 for OS, the key secondary end point. RESULTS: In all, 1,245 patients were randomly assigned to either tasquinimod (n = 832) or placebo (n = 413) between March 2011 and December 2012 at 241 sites in 37 countries. Baseline characteristics were balanced between groups: median age, 71 years; Karnofsky performance status ≥ 90%, 77.3%; and visceral metastases, 21.1%. Estimated median rPFS by central review was 7.0 months (95% CI, 5.8 to 8.2 months) with tasquinimod and 4.4 months (95% CI, 3.5 to 5.5 months) with placebo (HR, 0.64; 95% CI, 0.54 to 0.75; P < .001). Median OS was 21.3 months (95% CI, 19.5 to 23.0 months) with tasquinimod and 24.0 months (95% CI, 21.4 to 26.9 months) with placebo (HR, 1.10; 95% CI, 0.94 to 1.28; P = .25). Grade ≥ 3 adverse events were more frequent with tasquinimod (42.8% v 33.6%), the most common being anemia, fatigue, and cancer pain. CONCLUSION: In chemotherapy-naïve men with mCRPC, tasquinimod significantly improved rPFS compared with placebo. However, no OS benefit was observed

The rate of facultative sex governs the number of expected mating types in isogamous species

It is unclear why sexually reproducing isogamous species frequently contain just two self-incompatible mating types. Deterministic theory suggests that since rare novel mating types experience a selective advantage (by virtue of their many potential partners), the number of mating types should consistently grow. However, in nature, species with thousands of mating types are exceedingly rare. Several competing theories for the predominance of species with two mating types exist, yet they lack an explanation for how many are possible and in which species to expect high numbers. Here, we present a theoretical null model that explains the distribution of mating type numbers using just three biological parameters: mutation rate, population size and the rate of sex. If the number of mating types results from a mutation–extinction balance, the rate of sexual reproduction plays a crucial role. If sex is facultative and rare (a very common combination in isogamous species), mating type diversity will remain low. In this rare sex regime, small fitness differences between the mating types lead to more frequent extinctions, further lowering mating type diversity. We also show that the empirical literature supports the role of drift and facultativeness of sex as a determinant of mating type dynamics

The rate of facultative sex governs the number of expected mating types in isogamous species

It is unclear why sexually reproducing isogamous species frequently contain just two self-incompatible mating types. Deterministic theory suggests that since rare novel mating types experience a selective advantage (by virtue of their many potential partners), the number of mating types should consistently grow. However, in nature, species with thousands of mating types are exceedingly rare. Several competing theories for the predominance of species with two mating types exist, yet they lack an explanation for how many are possible and in which species to expect high numbers. Here, we present a theoretical null model that explains the distribution of mating type numbers using just three biological parameters: mutation rate, population size and the rate of sex. If the number of mating types results from a mutation–extinction balance, the rate of sexual reproduction plays a crucial role. If sex is facultative and rare (a very common combination in isogamous species), mating type diversity will remain low. In this rare sex regime, small fitness differences between the mating types lead to more frequent extinctions, further lowering mating type diversity. We also show that the empirical literature supports the role of drift and facultativeness of sex as a determinant of mating type dynamics