Quantum cooling and squeezing of a levitating nanosphere via time-continuous measurements

With the purpose of controlling the steady state of a dielectric nanosphere levitated within an optical cavity, we study its conditional dynamics under simultaneous sideband cooling and additional time-continuous measurement of either the output cavity mode or the nanosphere's position. We find that the average phonon number, purity and quantum squeezing of the steady-states can all be made more non-classical through the addition of time-continuous measurement. We predict that the continuous monitoring of the system, together with Markovian feedback, allows one to stabilize the dynamics for any value of the laser frequency driving the cavity. By considering state-of-the-art values of the experimental parameters, we prove that one can in principle obtain a non-classical (squeezed) steady-state with an average phonon number $n_{\sf ph}\approx 0.5$.Comment: 10 pages, 9 figures; v2: close to published versio

Proper Motion of Water Masers Associated with IRAS 21391+5802: Bipolar Outflow and an AU-Scale Dusty Circumstellar Shell

We present VLBA observations of water maser emission associated with the star-forming region IRAS 21391+5802, which is embedded in a bright rimmed cometary globule in IC1396. The angular resolution of the maps is about 0.8 mas, corresponding to a spatial resolution of about 0.6 AU, at an estimated distance of 750 pc. Proper motions are derived for 10 maser features identified consistently over three epochs, which were separated by intervals of about one month. The masers appear in four groups, which are aligned linearly on the sky, roughly along a northeast-southwest direction, with a total separation of about 520 AU (about 0.7 arcseconds). The 3-D velocities of the masers have a maximum value of about 42 km/s (about 9 AU/yr). The average error on the derived proper motions is about 4 km/s. The overall pattern of proper motions is indicative of a bipolar outflow. Proper motions of the masers in a central cluster, with a projected extent of about 20 AU, show systematic deviations from a radial outflow. However, we find no evidence of Keplerian rotation, as has been claimed elsewhere. A nearly circular loop of masers lies near the middle of the cluster. The radius of this loop is 1 AU and the line-of-sight velocities of the masers in the loop are within 2 km/s of the systemic velocity of the region. These masers presumably exist at the radial distance where significant dust condensation occurs in the outflow emanating from the star.Comment: 15 pages, 4 figures. Accepted for publication in the Astrophysical Journal. Version 2.12.00: Astrometric coordinates of maser revise

Using machine learning to detect the differential usage of novel gene isoforms

BACKGROUND: Differential isoform usage is an important driver of inter-individual phenotypic diversity and is linked to various diseases and traits. However, accurately detecting the differential usage of different gene transcripts between groups can be difficult, in particular in less well annotated genomes where the spectrum of transcript isoforms is largely unknown. RESULTS: We investigated whether machine learning approaches can detect differential isoform usage based purely on the distribution of reads across a gene region. We illustrate that gradient boosting and elastic net approaches can successfully identify large numbers of genes showing potential differential isoform usage between Europeans and Africans, that are enriched among relevant biological pathways and significantly overlap those identified by previous approaches. We demonstrate that diversity at the 3′ and 5′ ends of genes are primary drivers of these differences between populations. CONCLUSION: Machine learning methods can effectively detect differential isoform usage from read fraction data, and can provide novel insights into the biological differences between groups. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-022-04576-3

Calculations of polarizabilities and hyperpolarizabilities for the Be+^+ ion

The polarizabilities and hyperpolarizabilities of the Be$^+$ ion in the $2^2S$ state and the $2^2P$ state are determined. Calculations are performed using two independent methods: i) variationally determined wave functions using Hylleraas basis set expansions and ii) single electron calculations utilizing a frozen-core Hamiltonian. The first few parameters in the long-range interaction potential between a Be$^+$ ion and a H, He, or Li atom, and the leading parameters of the effective potential for the high-$L$ Rydberg states of beryllium were also computed. All the values reported are the results of calculations close to convergence. Comparisons are made with published results where available.Comment: 18 pp; added details to Sec. I

The Effects of Roadway Capacity on Peak Narrowing - Evidence from 1995 NPTS

Spreading of the peak is one effect of increased peak-period congestion. Due to peak spreading, the travel-time impact of congestion is mitigated for some travelers, but the inconvenience of traveling at a less-preferred time also has a cost. Alternatively, increases in capacity have their impacts on peak-period congestion mitigated by a narrowing of the peak. This reduces the travel-time savings, but it generates a benefit for those traveling closer to their preferred times. This benefit from capacity improvements has largely been ignored, and one reason is the difficulty of quantifying the effect. This paper reports on some crude attempts to quantify the peak-narrowing effect of increased capacity. Using 1995 Nationwide Personal Transportation Survey (NPTS) data, this study investigates how workers in Metropolitan Statistical Areas (MSAs) in the US respond to roadway capacity differences in terms of changing their departure time to work. It is assumed that there is some distribution of travel times given by a mean and some measure of deviation from the mean. Peak narrowing is then measured by decreases in the deviation from the mean. The peak narrowing effects are modeled for both the morning commute and all departures from home for work at any time of the day. As expected, in urban areas with higher roadway capacity per capita, workers tend to depart from home closer to the peak time. For the morning commute, the model estimates that each one-percent increase in lane-miles per capita results in workers departing from home about 5.75 percent closer to the peak time. The effects of roadway capacity are found to be statistically significant in both models

Evolution of a physical and biological front from upwelling to relaxation

© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Continental Shelf Research 108 (2015): 55-64, doi:10.1016/j.csr.2015.08.005.Fronts influence the structure and function of coastal marine ecosystems. Due to the complexity and dynamic nature of coastal environments and the small scales of frontal gradient zones, frontal research is difficult. To advance this challenging research we developed a method enabling an autonomous underwater vehicle (AUV) to detect and track fronts, thereby providing high-resolution observations in the moving reference frame of the front itself. This novel method was applied to studying the evolution of a frontal zone in the coastal upwelling environment of Monterey Bay, California, through a period of variability in upwelling intensity. Through 23 frontal crossings in four days, the AUV detected the front using real-time analysis of vertical thermal stratification to identify water types and the front between them, and the vehicle tracked the front as it moved more than 10 km offshore. The physical front coincided with a biological front between strongly stratified phytoplankton-enriched water inshore of the front, and weakly stratified phytoplankton-poor water offshore of the front. While stratification remained a consistent identifier, conditions on both sides of the front changed rapidly as regional circulation responded to relaxation of upwelling winds. The offshore water type transitioned from relatively cold and saline upwelled water to relatively warm and fresh coastal transition zone water. The inshore water type exhibited an order of magnitude increase in chlorophyll concentrations and an associated increase in oxygen and decrease in nitrate. It also warmed and freshened near the front, consistent with the cross-frontal exchange that was detected in the high-resolution AUV data. AUV-observed cross-frontal exchanges beneath the surface manifestation of the front emphasize the importance of AUV synoptic water column surveys in the frontal zone.This work was supported by the David and Lucile Packard Foundation

Structure and Function of a Chlorella Virus Encoded Glycosyltransferase

Paramecium bursaria chlorella virus-1 encodes at least 5 putative glycosyltransferases that are probably involved in the synthesis of the glycan components of the viral major capsid protein. The 1.6 Å crystal structure of one of these glycosyltransferases (A64R) has a mixed α/β fold containing a central, six-stranded β-sheet flanked by α-helices. Crystal structures of A64R, complexed with UDP, CMP, or GDP, established that only UDP bound to A64R in the presence of Mn2+, consistent with its high structural similarity to glycosyltransferases which utilize UDP as the sugar carrier. The structure of the complex of A64R, UDP-glucose, and Mn2+ showed that the largest conformational change occurred when hydrogen bonds were formed with the ligands. Unlike UDP-glucose, UDPgalactose and UDP-GlcNAc did not bind to A64R, suggesting a selective binding of UDP-glucose. Thus, UDP-glucose is most likely the sugar donor for A64R, consistent with glucose occurring in the virus major capsid protein glycans

Stochastic coarsening model for Pb islands on a Si(111) surface

The coarsening behavior of individual Pb islands on Si(111) surface has been studied by scanning tunneling microscopy. Traditionally island decay follows a smooth power-law dependence on the time until disappearance. In Pb/Si(111), some unstable islands are inactive for a long time but once their decay is triggered they suffer a “sudden death.” Four-layer islands are found to decay rapidly, increasing the area covered by seven-layer islands. All islands, decaying or otherwise, are accompanied by island size fluctuation which involve a large number of perimeter atoms moving collectively as a “quantized” unit. A stochastic model is developed to elucidate the mechanism behind this coarsening behavior of Pb islands. The distinct evolution of the islands with different heights is correctly predicted, and the size fluctuations of islands and the sudden death behavior observed in island coarsening are also recovered. The key ingredients are incorporation of accurate non-Gaussian statistics of the size fluctuations and also accounting for size changes in large quantized bursts