Not in My Social World: A Cultural Analysis of Media Representations, Contested Spaces, and Sympathy for the Homeless

The social constructionist approach offers conceptual tools that may augment social workers\u27 persuasive powers and problem solving capacities. In this case study, I examine a newspaper campaign to cast the homeless in negative terms and justify the closing of a shelter. Findings are presented as seven themes used by competing claims-makers. Each constructs a different depiction of the homeless, of homelessness, and of preferred solutions. Linkages between community memberships and favored problem definitions are identified. I conclude with suggestions for how intelligent social reconstruction might help social workers function as sympathy brokers for the vulnerable. (Key words: homelessness, NIMBY, mass media, constructionist approaches to social problems)

Multivariate regression smoothing through the 'fallling net'.

We consider multivariate regression smoothing through a conditional mean shift procedure. By computing local conditional means iteratively over a set or grid of target points, at each iteration a `net' is formed which gently drifts towards the data cloud, until it settles at the conditional modes of the response distribution. The method is edge-preserving and allows for multi-valued response

Black Child National Agenda: America Must Deliver on its Promise

Black children's lives matter. Unfortunately, Black children in the United States of America face a dual reality: growing up in the "land of opportunity" while also experiencing the reality of racism and inequities that impact their daily lives. The Equity Research ActionCoalition, POINTS of ACCESS, LLC, and the National Black Child Development Institute have collaborated in creating the Black Child National Agenda because of the urgent need to challenge the negative and stereotypical narrative of Black children, families, and communities and to challenge policies and systems that undermine basic human rights and community wellness

One and a Half-Stage Revision With Prosthetic Articulating Spacer for Definitive Management of Knee Periprosthetic Joint Infection.

This paper is a comprehensive review that describes indications, contraindications, clinical outcomes, and pearls and pitfalls of 1.5-stage revision total knee arthroplasty (TKA) utilizing a primary TKA femoral component, all-polyethylene tibial component, and hand-crafted antibiotic cement for the management of chronic periprosthetic joint infection. The 1.5-stage exchange TKA details placement of an articulating spacer for an indefinite period, prolonging revision until reinfection, deterioration of functional status, or construct failure. A 1.5-stage revision TKA technique is a viable option for treatment of chronic periprosthetic knee infections. The inherent advantages of decreased health-care costs, decreased morbidity and mortality, and improved emotional ease from having a single procedure is attractive, especially if reinfection rates are determined to be equivocal to 2-stage revision

Multivariate regression smoothing through the 'fallling net'

We consider multivariate regression smoothing through a conditional mean shift procedure. By computing local conditional means iteratively over a set or grid of target points, at each iteration a `net' is formed which gently drifts towards the data cloud, until it settles at the conditional modes of the response distribution. The method is edge-preserving and allows for multi-valued response

The impact of sphingosine-1-phosphate receptor modulators on COVID-19 and SARS-CoV-2 vaccination.

BACKGROUND: Sphingosine-one phosphate receptor (S1PR) modulation inhibits S1PR1-mediated lymphocyte migration, lesion formation and positively-impacts on active multiple sclerosis (MS). These S1PR modulatory drugs have different: European Union use restrictions, pharmacokinetics, metabolic profiles and S1PR receptor affinities that may impact MS-management. Importantly, these confer useful properties in dealing with COVID-19, anti-viral drug responses and generating SARS-CoV-2 vaccine responses. OBJECTIVE: To examine the biology and emerging data that potentially underpins immunity to the SARS-CoV-2 virus following natural infection and vaccination and determine how this impinges on the use of current sphingosine-one-phosphate modulators used in the treatment of MS. METHODS: A literature review was performed, and data on infection, vaccination responses; S1PR distribution and functional activity was extracted from regulatory and academic information within the public domain. OBSERVATIONS: Most COVID-19 related information relates to the use of fingolimod. This indicates that continuous S1PR1, S1PR3, S1PR4 and S1PR5 modulation is not associated with a worse prognosis following SARS-CoV-2 infection. Whilst fingolimod use is associated with blunted seroconversion and reduced peripheral T-cell vaccine responses, it appears that people on siponimod, ozanimod and ponesimod exhibit stronger vaccine-responses, which could be related notably to a limited impact on S1PR4 activity. Whilst it is thought that S1PR3 controls B cell function in addition to actions by S1PR1 and S1PR2, this may be species-related effect in rodents that is not yet substantiated in humans, as seen with bradycardia issues. Blunted antibody responses can be related to actions on B and T-cell subsets, germinal centre function and innate-immune biology. Although S1P1R-related functions are seeming central to control of MS and the generation of a fully functional vaccination response; the relative lack of influence on S1PR4-mediated actions on dendritic cells may increase the rate of vaccine-induced seroconversion with the newer generation of S1PR modulators and improve the risk-benefit balance IMPLICATIONS: Although fingolimod is a useful asset in controlling MS, recently-approved S1PR modulators may have beneficial biology related to pharmacokinetics, metabolism and more-restricted targeting that make it easier to generate infection-control and effective anti-viral responses to SARS-COV-2 and other pathogens. Further studies are warranted

Brief of Amici Curiae Professors Ronald A. Cass, David F. Forte, James L. Huffman, Donald J. Kochan, Jesse J. Richardson and Reed Watson in Support of Petitioners

The Court of Federal Claims ruled that the Klamath, Yurok and Hoopa (hereafter Tribes) reserved water rights in the Klamath River Basin are of a volume at least equal to the amount of water the Environmental Protection Agency has determined to be necessary to trigger endangered species protection. In the absence of an adjudication in state or federal court and contrary to the long history of federal deference (both by Congressional enactment and judicial precedent) to state adjudication of water rights, the Federal Circuit affirmed and thus preempted, without the participation of affected parties including petitioners, the State of Oregon’s ongoing adjudication of Klamath Basin water rights. Independent of the 5th Amendment takings issue at the root of this case, the Federal Circuit’s decision raises serious federalism issues that this Court should address. Few matters are of more importance to western states like Oregon than the allocation of scarce water resources. For a century and a half this Court and Congress have mandated federal court deference to the states’ administration and adjudication of water rights. Deference is particularly important to the wise administration of this scarce resource where there is an ongoing state court adjudication and where no federal interest will be compromised. As with asserting any reserved rights claims of its own, the federal government has every opportunity to exercise its role as trustee for the Tribes in the state court adjudication

Obesity and its effect on outcomes in same-day bilateral total knee arthroplasty

Background: The niche surgery of same-day bilateral total knee arthroplasty (sd-BTKA) continues to create debate amongst specialists in arthroplasty. To date, there is a significant lack of literature on obese patients undergoing sd-BTKA, and no study has evaluated outcomes of this procedure when compared to non-obese patients. Therefore, this study will perform a retrospective analysis to compare (I) incidence, (II) demographics, and (III) complications of sd-BTKA in non-obese, obese, and morbidly obese patients in the United States from 2009 to 2016. Methods: The National Inpatient Sample (NIS) database was queried for all individuals that underwent sd-BTKA from 2009 to 2016. This returned 184,844 non-obese patients, 39,901 obese patients, and 20,394 morbidly obese patients. Analyzed variables included mean age, mean length of stay (LOS), race, payer, age-adjusted Charlson Comorbidity Index score, discharge disposition, hospital charges, hospital costs, and complications. Chi-square analyses and analyses of variance were utilized to assess categorical and continuous variables, respectively. Results: Non-obese patients most commonly underwent sd-BTKA over the course of the study. As weight status increased, mean age decreased and the proportion of females, LOS, hospital charges and costs, and proportion of discharges to skilled nursing facilities increased. Regression analysis demonstrated obese and morbidly obese cohorts were at an overall increased odds for experiencing complications. Specifically, obese patients were at increased risk for pulmonary emboli, periprosthetic joint infections, and respiratory failures, while morbidly obese patients are at increased risk for pulmonary emboli, respiratory failures, and urinary tract infections. Conclusions: Surgeons should thoroughly evaluate the risks and benefits of performing sd-BTKA on obese and morbidly obese patients, as both confer higher overall complication rates and increased length of stay. More research is necessary to characterize the cost analysis of this procedure, as health care models continue to transition to more cost-effective procedures