Computational Efficiency: A Common Organizing Principle for Parallel Computer Maps and Brain Maps?

It is well-known that neural responses in particular brain regions are spatially organized, but no general principles have been developed that relate the structure of a brain map to the nature of the associated computation. On parallel computers, maps of a sort quite similar to brain maps arise when a computation is distributed across multiple processors. In this paper we will discuss the relationship between maps and computations on these computers and suggest how similar considerations might also apply to maps in the brain

Using transfer entropy to study synaptic integration in Purkinje cells

Peer reviewe

The Color-Magnitude Relation in Coma: Clues to the Age and Metallicity of Cluster Populations

We have observed three fields of the Coma cluster of galaxies with a narrow band (modified Stromgren) filter system. Observed galaxies include 31 in the vicinity of NGC 4889, 48 near NGC 4874, and 60 near NGC 4839 complete to M_5500=-18 in all three subclusters. Spectrophotometric classification finds all three subclusters of Coma to be dominated by red, E type (ellipticals/S0's) galaxies with a mean blue fraction, f_B, of 0.10. The blue fraction increases to fainter luminosities, possible remnants of dwarf starburst population or the effects of dynamical friction removing bright, blue galaxies from the cluster population by mergers. We find the color-magnitude (CM) relation to be well defined and linear over the range of M_5500=-13 to -22. After calibration to multi-metallicity models, bright ellipticals are found to have luminosity weighted mean [Fe/H] values between -0.5 and +0.5, whereas low luminosity ellipticals have [Fe/H] values ranging from -2 to solar. The lack of CM relation in our continuum color suggests that a systematic age effect cancels the metallicity effects in this bandpass. This is confirmed with our age index which finds a weak correlation between luminosity and mean stellar age in ellipticals such that the stellar populations of bright ellipticals are 2 to 3 Gyrs younger than low luminosity ellipticals.Comment: 26 pages AAS LaTeX, 6 figures, accepted for publication in A

Hierarchical galaxy formation and substructure in the Galaxy's stellar halo

We develop an explicit model for the formation of the stellar halo from tidally disrupted, accreted dwarf satellites in the cold dark matter (CDM) framework, focusing on predictions testable with the Sloan Digital Sky Survey (SDSS) and other wide-field surveys. Subhalo accretion and orbital evolution are calculated using a semi-analytic approach within the Press-Schechter formalism. Motivated by our previous work, we assume that low-mass subhalos (v < 30 km/s) can form significant populations of stars only if they accreted a substantial fraction of their mass before the epoch of reionization. With this assumption, the model reproduces the observed velocity function of galactic satellites in the Local Group, solving the ``dwarf satellite problem'' without modifying the popular LCDM cosmology. The disrupted satellites yield a stellar distribution with a total mass and radial density profile consistent with those observed for the Milky Way stellar halo. Most significantly, the model predicts the presence of many large-scale, coherent substructures in the outer halo. These substructures are remnants of individual, tidally disrupted dwarf satellite galaxies. Substructure is more pronounced at large galactocentric radii because of the smaller number density of tidal streams and the longer orbital times. This model provides a natural explanation for the coherent structures in the outer stellar halo found in the SDSS commissioning data, and it predicts that many more such structures should be found as the survey covers more of the sky. The detection (or non-detection) and characterization of such structures could eventually test variants of the CDM scenario, especially those that aim to solve the dwarf satellite problem by enhancing satellite disruption.Comment: 12 pages, 8 figures, Submitted to Ap

An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease

Although the presence of an olfactory impairment in Parkinson's disease (PD) has been recognized for 25 years, its cause remains unclear. Here we suggest a contributing factor to this impairment, namely, that PD impairs active sniffing of odorants. We tested 10 men and 10 women with clinically typical PD, and 20 age- and gender-matched healthy controls, in four olfactory tasks: (i) the University of Pennsylvania smell identification test; (ii and iii) detection threshold tests for the odorants vanillin and propionic acid; and (iv) a two-alternative forced-choice detection paradigm during which sniff parameters (airflow peak rate, mean rate, volume, and duration) were recorded with a pneomatotachograph-coupled spirometer. An additional experiment tested the effect of intentionally increasing sniff vigor on olfactory performance in 20 additional patients. PD patients were significantly impaired in olfactory identification (P < 0.0001) and detection (P < 0.007). As predicted, PD patients were also significantly impaired at sniffing, demonstrating significantly reduced sniff airflow rate (P < 0.01) and volume (P < 0.002). Furthermore, a patient's ability to sniff predicted his or her performance on olfactory tasks, i.e., the more poorly patients sniffed, the worse their performance on olfaction tests (P < 0.009). Finally, increasing sniff vigor improved olfactory performance in those patients whose baseline performance had been poorest (P < 0.05). These findings implicate a sniffing impairment as a component of the olfactory impairment in PD and further depict sniffing as an important component of human olfaction

4098 galaxy clusters to z~0.6 in the Sloan Digital Sky Survey equatorial Stripe 82

We present a catalogue of 4098 photometrically selected galaxy clusters with a median redshift = 0.32 in the 270 square degree 'Stripe 82' region of the Sloan Digital Sky Survey (SDSS), covering the celestial equator in the Southern Galactic Cap (-50 < RA < 59 deg, |Dec| < 1.25 deg). Owing to the multi-epoch SDSS coverage of this region, the ugriz photometry is ~2 magnitudes deeper than single scans within the main SDSS footprint. We exploit this to detect clusters of galaxies using an algorithm that searches for statistically significant overdensities of galaxies in a Voronoi tessellation of the projected sky. 32% of the clusters have at least one member with a spectroscopic redshift from existing public data (SDSS Data Release 7, 2SLAQ & WiggleZ), and the remainder have a robust photometric redshift (accurate to ~5-9% at the median redshift of the sample). The weighted average of the member galaxies' redshifts provides a reasonably accurate estimate of the cluster redshift. The cluster catalogue is publicly available for exploitation by the community to pursue a range of science objectives. In addition to the cluster catalogue, we provide a linked catalogue of 18,295 V<21 mag quasar sight-lines with impact parameters within <3 Mpc of the cluster cores selected from the catalogue of Veron et al. (2010). The background quasars cover 0.25 < z < 2, where MgII absorption-line systems associated with the clusters are detectable in optical spectra.Comment: 10 pages, 2 figures, accepted for publication in MNRAS. Catalogues available at http://www.physics.mcgill.ca/~jimgeach/stripe8

HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1

One of the major features of cancer is Otto Warburg's observation that many tumors have increased extracellular acidification compared to healthy tissues. Since Warburg's observation, the importance of extracellular acidification in cancer is now considered a hallmark of cancer. Human MAP3K4 functions upstream of the p38 and JNK mitogen activated protein kinases (MAPKs). Additionally, MAP3K4 is required for cell migration and extracellular acidification of breast cancer cells in response to HER2/HER3 signaling. Here, we demonstrate that GIT1 interacts with MAP3K4 by immunoprecipitation, while cellular lactate production and the capacity of MCF-7 cells for anchorage independent growth in soft agar were dependent on GIT1. Additionally, we show that activation of HER2/HER3 signaling leads to reduced expression of lactate receptor (GPR81) mRNA and that both, GIT1 and MAP3K4, are necessary for constitutive expression of GPR81 mRNA. Our study suggests that targeting downstream proteins in the HER2/HER3-induced extracellular lactate signaling pathway may be a way to inhibit the Warburg Effect to disrupt tumor growth.NIEHS Training grant [ES007091]; Arizona Science Foundation [CAA 0226-08, ES006694, ES012007, ES04940]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Neural Control of Sensory Acquisition: The Vestibulo-Ocular Reflex

We present a new hypothesis that the cerebellum plays a key role in actively controlling the acquisition of sensory infonnation by the nervous system. In this paper we explore this idea by examining the function of a simple cerebellar-related behavior, the vestibula-ocular reflex or VOR, in which eye movements are generated to minimize image slip on the retina during rapid head movements. Considering this system from the point of view of statistical estimation theory, our results suggest that the transfer function of the VOR, often regarded as a static or slowly modifiable feature of the system, should actually be continuously and rapidly changed during head movements. We further suggest that these changes are under the direct control of the cerebellar cortex and propose experiments to test this hypothesis