Measurements of static and dynamic displacement from visual monitoring of the Humber Bridge

Author's manuscript version. The final published version is available from the publisher via doi:10.1016/0141-0296(93)90054-8. Copyright © 1993 Published by Elsevier Ltd.A visual tracking system has been employed in the measurement of deck displacements at the centre of the 1410 m span of the Humber Bridge in the UK. The transputer-based system was developed for applications such as the monitoring or testing of large physical structures, where the actual displacements may not easily be otherwise determined. The system employs parallel processing techniques to track predictively the motion of multiple, independent objects at video frame rate. Results obtained using the system in a monitoring programme of the bridge are presented and discussed. © 1993

Can't get no learning: the Brexit fiasco through the lens of policy learning

It seems paradoxical to suggest that theories of learning might be used to explain policy failure. Yet the Brexit fiasco connects with recent approaches linking varieties of policy learning to policy pathologies. This article sets out to explain the UK government’s (mis)management of the Brexit process from June 2016 to May 2019 from a policy learning perspective. Drawing on interviews with UK policy-makers and stakeholders, we ask how did the UK government seek to learn during the Brexit negotiations? We consider four modes of learning: reflexivity, epistemic, hierarchical, and bargaining. By empirically tracing the policy process and scope conditions for each of these, we argue that learning through the first three modes proved highly dysfunctional. This forced the government to rely on bargaining between competing factions, producing a highly political form of learning which stymied the development of a coherent Brexit strategy. We argue that the analysis of Brexit as a policy process – rather than a political event – reveals how policy dynamics play an important role in shaping the political context within which they are located. The article concludes that public policy analysis can, therefore, add significant value to our understanding of Brexit by endogenising accounts of macro political developments

The effects of peculiar velocities in SN Ia environments on the local H0 measurement

The discrepancy between estimates of the Hubble Constant ($H_{0}$) measured from local ($z \lesssim 0.1$) scales and from scales of the sound horizon is a crucial problem in modern cosmology. Peculiar velocities of standard candle distance indicators can systematically affect local $H_{0}$ measurements. We here use 2MRS galaxies to measure the local galaxy density field, finding a notable $z < 0.05$ under-density in the SGC-6dFGS region of $27 \pm 2$ %. However, no strong evidence for a 'Local Void' pertaining to the full 2MRS sky coverage is found. Galaxy densities are used to measure a density parameter, $\Delta \phi_{+-}$, which acts as a proxy for peculiar velocity ($v_{pec}$) by quantifying density gradients along a line-of-sight. $\Delta \phi_{+-}$ is found to correlate strongly with local $H_{0}$ estimates from Union 2.1 Type Ia SNe ($0.02 < z < 0.04$). Density structures on scales of $\sim 50$ Mpc are found to correlate most strongly with $H_{0}$ estimates in both the observational data and in mock data from the MDPL2-Galacticus simulation. Interpolating SN Ia $H_{0}$ estimates to their $\Delta \phi_{+-} = 0$ values, we can correct for the effects of density structure on the local $H_{0}$ estimates, even in the presence of biased peculiar velocities. For these particular observational data, we reveal a $< 0.1 \,\rm km\,s^{-1} Mpc^{-1}$ difference in the sample mean estimate compared to the value uncorrected for peculiar velocities. Our best estimate is then $74.9 \,\rm km\,s^{-1} Mpc^{-1}$. Using the mock data, the systematic uncertainty from these peculiar velocity corrections is estimated to be $0.3 \,\rm km\,s^{-1} Mpc^{-1}$. The dominant source of uncertainty in our estimate instead relates to Cepheid-based calibrations of distance moduli ($1.7 \,\rm km\,s^{-1} Mpc^{-1}$) and SN photometry ($0.7 \,\rm km\,s^{-1} Mpc^{-1}$)

The role of genetics in cardiovascular disease: arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is a heritable cardiomyopathy characterized by frequent ventricular arrhythmias and progressive ventricular dysfunction. Risk of sudden cardiac death is elevated in ACM patients and can be the presenting symptom particularly in younger individuals and athletes. This review describes current understanding of the genetic architecture of ACM and molecular mechanisms of ACM pathogenesis. We consider an emerging threshold model for ACM inheritance in which multiple factors including pathogenic variants in known ACM genes, genetic modifiers, and environmental exposures, particularly exercise, are required to reach a threshold for disease expression. We also review best practices for integrating genetics—including recent discoveries—in caring for ACM families and emphasize the utility of genotype for both management of affected individuals and predictive testing in family members

Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies: JACC Focus Seminar 3/5

Inherited cardiomyopathies are commonly occurring myocardial disorders that are associated with substantial morbidity and mortality. Clinical management strategies have focused on treatment of heart failure and arrhythmic complications in symptomatic patients according to standardized guidelines. Clinicians are now being urged to implement precision medicine, but what does this involve? Advances in understanding of the genetic underpinnings of inherited cardiomyopathies have brought new possibilities for interventions that are tailored to genes, specific variants, or downstream mechanisms. However, the phenotypic variability that can occur with any given pathogenic variant suggests that factors other than single driver gene mutations are often involved. This is propelling a new imperative to elucidate the nuanced ways in which individual combinations of genetic variation, comorbidities, and lifestyle may influence cardiomyopathy phenotypes. Here, Part 3 of a 5-part precision medicine Focus Seminar series reviews the current status and future opportunities for precision medicine in the inherited cardiomyopathies

A metabolite binding protein moonlights as a bile- responsive chaperone

Bile salts are secreted into the gastrointestinal tract to aid in the absorption of lipids. In addition, bile salts show potent antimicrobial activity in part by mediating bacterial protein unfolding and aggregation. Here, using a protein folding sensor, we made the surprising discovery that the Escherichia coli periplasmic glycerol- 3- phosphate (G3P)- binding protein UgpB can serve, in the absence of its substrate, as a potent molecular chaperone that exhibits anti- aggregation activity against bile salt- induced protein aggregation. The substrate G3P, which is known to accumulate in the later compartments of the digestive system, triggers a functional switch between UgpB’s activity as a molecular chaperone and its activity as a G3P transporter. A UgpB mutant unable to bind G3P is constitutively active as a chaperone, and its crystal structure shows that it contains a deep surface groove absent in the G3P- bound wild- type UgpB. Our work illustrates how evolution may be able to convert threats into signals that first activate and then inactivate a chaperone at the protein level in a manner that bypasses the need for ATP.SynopsisThe periplasmic glycerol- 3- phosphate binding protein, UgpB, was found to have dual functions, as a metabolite binding protein and as a bile- responsive molecular chaperone. Stomach- acid induced stripping of its glycerol- 3- phosphate substrate functions as a switch that activates the chaperone activity of UgpB.A tripartite periplasmic protein folding sensor and Tn- Seq uncover UgpB as a new chaperone.UgpB prevents bile- induced protein aggregation when in its G3P- free form.Stomach acid- induced G3P stripping activates UgpB chaperone function.Crystal structure of a G3P- nonbinding variant of UgpB reveals opening of a deep surface groove when compared to the structure of G3P- bound wild- type UgpB.A periplasmic folding sensor reveals a mechanism by which stomach acid- induced G3P stripping remodels UgpB into a chaperone that prevents bile- induced bacterial protein aggregation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/6/embj2019104231.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/5/embj2019104231-sup-0002-EVFigs.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/4/embj2019104231-sup-0006-SDataFig3.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/3/embj2019104231.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/2/embj2019104231_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163430/1/embj2019104231-sup-0005-SDataFig2.pd

NORFOLK (Reino Unido). Inglaterra. Condado. Mapas generales. 1755?. 1:115000

Fecha tomada de "Tooley's dictionary of Mapmakers", Tring, 1979, y 132Escala hallada a partir de un minuto de latitud [= 1,6 cm]. Coordenadas referidas a un meridiano que no se especifica, sin que sea posible además constatar la longitud por señalar únicamente minutos y no los grados entre los que están comprendida la latitud (N 53°10'--N 52°26'). Recuadro geográfico de 1' en 1'Orografía de perfilDiferencia por colores los límites entre distintas divisiones del condadoEn los márgenes derecho e izquierdo aparecen unas tablas con los nombres de todas las ciudades. En el margen inferior una leyenda explica cómo hallar la escalaTítulo enmarcado en cartela decorada con dos angelotes y un escudoInserta : "The West Prospect of the Town of Great Yarmouth, likewise the Denos and Roads : this Town is hear a Mile from the South Gales, to the North Gales, Survey'd pr. I Corbridge". The North East Prospect of Norwich". West Prospect of Lynn

Survey of ultrasound practice amongst podiatrists in the UK

Background: Ultrasound in podiatry practice encompasses musculoskeletal ultrasound imaging, vascular hand-held Doppler ultrasound and therapeutic ultrasound. Sonography practice is not regulated by the Health and Care Professions Council (HCPC), with no requirement to hold a formal qualification. The College of Podiatry does not currently define ultrasound training and competencies. This study aimed to determine the current use of ultrasound, training received and mentorship received and/or provided by podiatrists using ultrasound. Methods: A quantitative study utilising a cross-sectional, on-line, single-event survey was undertaken within the UK. Results: Completed surveys were received from 284 podiatrists; 173 (70%) use ultrasound as part of their general practice, 139 (49%) for musculoskeletal problems, 131 (46%) for vascular assessment and 39 (14%) to support their surgical practice. Almost a quarter (n=62) worked for more than one organisation; 202 (71%) were employed by the NHS and/or private sector (n=118, 41%). Nearly all (93%) respondents report using a hand-held vascular Doppler in their daily practice; 216 (82%) to support decisions regarding treatment options, 102 (39%) to provide diagnostic reports for other health professionals, and 34 (13%) to guide nerve blocks. Ultrasound imaging was used by 104 (37%) respondents primarily to aid clinical decision making (n=81) and guide interventions (steroid injections n=67; nerve blocks n=39). Ninety-three percent stated they use ultrasound imaging to treat their own patients, while others scan at the request of other podiatrists (n=28) or health professionals (n=18). Few use ultrasound imaging for research (n=7) or education (n=2). Only 32 (11%) respondents (n=20 private sector) use therapeutic ultrasound to treat patients presenting with musculoskeletal complaints, namely tendon pathologies. Few respondents (18%) had completed formal post-graduate CASE (Consortium for the Accreditation of Sonographic Education) accredited ultrasound courses. Forty (14%) respondents receive ultrasound mentorship; the majority from fellow podiatrists (n=17) or medical colleagues (n=15). Over half (n=127) who do not have ultrasound mentorship indicated they would like a mentor predominantly for ultrasound imaging. Fifty-five (19%) report they currently provide ultrasound mentorship for others. Conclusions: Understanding the scope of ultrasound practice, the training undertaken and the requirements for mentorship will underpin the development of competencies and recommendations defined by the College of Podiatry to support professional development and ensure safe practice.</p