Nanotechnology and cancer

The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. The goal of the presentation is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies

Effect of model selection on combustor performance and stability predictions using ROCCID

The ROCket Combustor Interactive Design (ROCCID) methodology is an interactive computer program that combines previously developed combustion analysis models to calculate the combustion performance and stability of liquid rocket engines. Test data from 213 kN (48,000 lbf) Liquid Oxygen (LOX)/RP-1 combustor with an O-F-O (oxidizer-fuel-oxidizer) triplet injector were used to characterize the predictive capabilities of the ROCCID analysis models for this injector/propellant configuration. Thirteen combustion performance and stability models were incorporated into ROCCID, and ten of them, which have options for triplet injectors, were examined. Calculations using different combinations of analysis models, with little or no anchoring, were carried out on a test matrix of operating combinations matching those of the test program. Results of the computer analyses were compared to test data, and the ability of the model combinations to correctly predict combustion stability or instability was determined. For the best model combination(s), sensitivity of the calculations to fuel drop size and mixing efficiency was examined. Error in the stability calculations due to uncertainty in the pressure interaction index (N) was examined. The recommended model combinations for this O-F-O triplet LOX/RP-1 configuration are proposed

Farm-gate phosphorus balances and soil phosphorus concentrations on intensive dairy farms in the south-west of Ireland

peer-reviewedThis project was part funded by the European Research and Development Fund under INTERREG IIIB: Green Dairy Project Number 100 and partly by the Dairy Levy. Financial support for post-graduate students involved in this study was provided by the Teagasc Walsh Fellowship Scheme.Phosphorus (P) loss to water is a significant threat to water quality in Ireland. Agriculture is an important source of this P. There is concern about balancing agronomic requirements and environmental protection in regulations prescribing P management on farms. This study examined farm-gate (P) balances and soil test P (STP) concentrations on 21 dairy farms in the south west of Ireland over four years, from 2003 to 2006 inclusive. Stocking density on the farms averaged 2.4 (s.d. = 0.4) livestock units (LU) per ha. Annual mean import of P onto farms was 21.6 (1.9) kg P/ha. Fertilizer P accounted for 47% (0.041), concentrates 35% (0.060) and organic manures 18% (0.034) of imported P. The mean annual P balance per farm was 9.4 (1.2) kg/ha, ranging from –3 to 47 kg/ha and mean P use efficiency was 0.71 (0.05) ranging from 0.24 to 1.37. The mean STP per farm following extraction using Morgan’s solution was 8.15 (2.9) mg/L of soil and ranged from 4.4 (2.2) to 14.7 (6.4) mg/L. There was a positive relationship (R2 = 0.34; P < 0.01) between STP and P balance; farms with a deficit of P tended to have agronomically sub-optimal STP and vice versa. The high between- and withinfarm variation in STP indicates that farmers were either unaware or were not making efficient use of STP results, and consequently there was agronomically sub-optimal soil P status in some fields and potentially environmentally damaging excesses on others (often within one farm). There was considerable potential to improve P management practices on these farms with clear agronomic and environmental benefits.European UnionTeagasc Walsh Fellowship ProgrammeDairy Levy Fun

Melt densities in the Na2O-FeO-Fe2O3-SiO2 system and the partial molar volume of tetrahedrally-coordinated ferric iron in silicate melts

The densities of 12 melts in the Na2O-FeO-Fe2O3-SiO2 system have been determined in equilibrium with air, in the temperature range of 1000–1500°C, using the double bob, Archimedean technique. Ferrous iron determinations of 100–200 mg samples, “dip” quenched from high temperature, indicate that all the melts investigated were highly oxidized under these experimental conditions. 57Fe Mössbauer spectra of glasses obtained by drop quenching 80 mg melt samples from loop equilibration runs yield Fe3+/Fe2+ data equivalent to that for the densitometry (dip) samples for all but the most viscous melt, and confirm that all but one melt equilibrated with air during the densitometry measurements. Melt densities range from 2.17 to 2.88 g/cm3 with a mean standard deviation (from replicate experiments) of 0.36%. Least squares regression of the density data at 1300, 1400 and 1500°C, was calculated, both excluding and including excess volume terms (herein named linear and nonlinear fits, respectively) and the root mean squared deviation (RMSD) of each regression was compared with the total experimental error. The partial molar volumes computed for linear fits for Na2O and SiO2 are similar to those previously reported for melts in the Na2O-Al2O3-SiO2 system (Steinet al., 1986). The partial molar volumes of Fe2O3 obtained in these linear fits are equal to those obtained by Shiraishi et al. (1978) in the FeO-Fe2O3-SiO2 system but 5 to 10% lower than reported by Mo et al. (1982) in multicomponent melts. The partial molar volume exhibited by Fe3+ in this system is representative of the partial molar volume of tetrahedrally coordinated Fe3+ in silicate melts

Combination of geodetic observations and models for glacial isostatic adjustment fields in Fennoscandia

We demonstrate a new technique for using geodetic data to update a priori predictions for Glacial Isostatic Adjustment (GIA) in the Fennoscandia region. Global Positioning System (GPS), tide gauge, and Gravity Recovery and Climate Experiment (GRACE) gravity rates are assimilated into our model. The technique allows us to investigate the individual contributions from these data sets to the output GIA model in a self-consistent manner. Another benefit of the technique is that we are able to estimate uncertainties for the output model. These are reduced with each data set assimilated. Any uncertainties in the GPS reference frame are absorbed by reference frame adjustments that are estimated as part of the assimilation. Our updated model shows a spatial pattern and magnitude of peak uplift that is consistent with previous models, but our location of peak uplift is slightly to the east of many of these. We also simultaneously estimate a spatially averaged rate of local sea level rise. This regional rate (similar to 1.5 mm/yr) is consistent for all solutions, regardless of which data sets are assimilated or the magnitude of a priori GPS reference frame constraints. However, this is only the case if a uniform regional gravity rate, probably representing errors in, or unmodeled contributions to, the low-degree harmonic terms from GRACE, is also estimated for the assimilated GRACE data. Our estimated sea level rate is consistent with estimates obtained using a more traditional approach of direct "correction" using collocated GPS and tide gauge site

Carbon changes in conterminous US forests associated with growth and major disturbances.

Abstract We estimated forest area and carbon changes in the conterminous United States using a remote sensing based land cover change map, forest fire data from the Monitoring Trends in Burn Severity program, and forest growth and harvest data from the USDA Forest Service, Forest Inventory and Analysis Program. Natural and human-associated disturbances reduced the forest ecosystems\u27 carbon sink by 36% from 1992 to 2001, compared to that without disturbances in the 48 states. Among the three identified disturbances, forest-related land cover change contributed 33% of the total effect in reducing the forest carbon potential sink, while harvests and fires accounted for 63% and 4% of the total effect, respectively. The nation\u27s forests sequestered 1.6 ± 0.1Pg (1015 petagram) carbon during the period, or 0.18PgCyr-1, with substantial regional variation. The southern region of the United States was a small net carbon source whereas the greater Pacific Northwest region was a strong net sink. Results of the approach fit reasonably well at an aggregate level with other related estimates of the current forest US greenhouse gas inventory, suggesting that further research using this approach is warranted

Aeolian removal of dust from photovoltaic surfaces on Mars

It is well documented that Mars is totally engulfed in huge dust storms nearly each Martian year. Dust elevated in these global dust storms, or in any of the numerous local dust storms could settle on photovoltaic surfaces and seriously hamper photovoltaic power system performance. Using a recently developed technique to uniformly dust simulated photovoltaic surfaces, samples were subjected to Martian-like winds in an attempt to determine whether natural aeolian processes on Mars would sweep off the settled dust. The effects of wind velocity, angle of attack, height off the Martian surface, and surface coating material were investigated. Principles which can help to guide the design of photovoltaic arrays bound for the Martian surface were uncovered. Most importantly, arrays mounted with an angle of attack approaching 45 deg show the most efficient clearing. Although the angular dependence is not sharp, horizontally mounted arrays required significantly higher wind velocities to clear off the dust. From the perspective of dust-clearing it appears that the arrays may be erected quite near the ground, but previous studies have suggested that saltation effects can be expected to cause such arrays to be covered by sand if they are set up less than about a meter from the ground. Providing that the surface chemistry of Martian dusts is comparable to our test dust, the materials used for protective coating may be optimized for other considerations such as transparency, and chemical or abrasion resistance. The static threshold velocity is low enough that there are regions on Mars which experience winds strong enough to clear off a photovoltaic array if it is properly oriented. Turbulence fences proved to be an ineffective strategy to keep dust cleared from the photovoltaic surfaces