Mariner IV Mission to Mars. Part I

This technical report is a series of individual papers documenting the Mariner-Mars project from its beginning in 1962 following the successful Mariner-Venus mission. Part I is pre-encounter data. It includes papers on the design, development, and testing of Mariner IV, as well as papers detailing methods of maintaining communication with and obtaining data from the spacecraft during flight, and expected results during encounter with Mars. Part 11, post-encounter data, to be published later, will consist of documentation of the events taking place during Mariner IV's encounter with Mars and thereafter. The Mariner-Mars mission, the culmination of an era of spacecraft development, has contributed much new technology to be used in future projects

Value added or misattributed? A multi-institution study on the educational benefit of labs for reinforcing physics content

Instructional labs are widely seen as a unique, albeit expensive, way to teach scientific content. We measured the effectiveness of introductory lab courses at achieving this educational goal across nine different lab courses at three very different institutions. These institutions and courses encompassed a broad range of student populations and instructional styles. The nine courses studied had two key things in common: the labs aimed to reinforce the content presented in lectures, and the labs were optional. By comparing the performance of students who did and did not take the labs (with careful normalization for selection effects), we found universally and precisely no added value to learning from taking the labs as measured by course exam performance. This work should motivate institutions and departments to reexamine the goals and conduct of their lab courses, given their resource-intensive nature. We show why these results make sense when looking at the comparative mental processes of students involved in research and instructional labs, and offer alternative goals and instructional approaches that would make lab courses more educationally valuable.Comment: Accepted to Phys Rev PE

Big Sagebrush Response to One-Way and Two-Way Chaining in Southeastern Utah

A decadent, mixed stand of Wyoming big sagebrush, Artemisia tridentata wyomingensis, and mountain big sagebrush, Artemisia tridentata vaseyana, located north of Cisco, Utah, was subjected to one-way and two-way chaining treatments in November 1987. The effect of the treatments on plant community characteristics and shrub vigor was documented over a 3-year period. Stand density was reduced 60 percent on sites chained two ways and 43 percent on sites chained over once. Shrubs on one-way chained sites produced more leader growth in 1989 and 1990 than those on untreated sites or sites chained two ways. Browse production on one-way chained sites surpassed that of untreated sites and two-way chained sites by 140 percent and 350 percent, respectively. Over the short term, a one-way chaining was shown to be an effective method for improving sagebrush vigor and production on a critical mule deer winter range

Mitochondrial ROS cause motor deficits induced by synaptic inactivity:implications for synapse pruning

Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To begin to unravel whether mitochondrial ROS regulate pruning, we made the local consequences of neuromuscular junction (NMJ) pruning detectable as motor deficits by using disparate exogenous and endogenous models to induce synaptic inactivity en masse in developing Xenopus laevis tadpoles. We resolved whether: (1) synaptic inactivity increases mitochondrial ROS; and (2) antioxidants rescue synaptic inactivity induced motor deficits. Regardless of whether it was achieved with muscle (α-bugarotoxin), nerve (α-latrotoxin) targeted neurotoxins or an endogenous pruning cue (SPARC), synaptic inactivity increased mitochondrial ROS in vivo. The manganese porphyrins MnTE-2-PyP5+ and/or MnTnBuOE-2-PyP5+ blocked mitochondrial ROS to significantly reduce neurotoxin and endogenous pruning cue induced motor deficits. Selectively inducing mitochondrial ROS—using mitochondria-targeted Paraquat (MitoPQ)—recapitulated synaptic inactivity induced motor deficits; which were significantly reduced by blocking mitochondrial ROS with MnTnBuOE-2-PyP5+. We unveil mitochondrial ROS as synaptic activity sentinels that regulate the phenotypical consequences of forced synaptic inactivity at the NMJ. Our novel results are relevant to pruning because synaptic inactivity is one of its defining features

In-flight radiometric calibration of the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS)

A reflectance-based method was used to provide an analysis of the in-flight radiometric performance of AVIRIS. Field spectral reflectance measurements of the surface and extinction measurements of the atmosphere using solar radiation were used as input to atmospheric radiative transfer calculations. Five separate codes were used in the analysis. Four include multiple scattering, and the computed radiances from these for flight conditions were in good agreement. Code-generated radiances were compared with AVIRIS-predicted radiances based on two laboratory calibrations (pre- and post-season of flight) for a uniform highly reflecting natural dry lake target. For one spectrometer (C), the pre- and post-season calibration factors were found to give identical results, and to be in agreement with the atmospheric models that include multiple scattering. This positive result validates the field and laboratory calibration technique. Results for the other spectrometers (A, B and D) were widely at variance with the models no matter which calibration factors were used. Potential causes of these discrepancies are discussed

Abelian D-terms and the superpartner spectrum of anomaly-mediated supersymmetry breaking

We address the tachyonic slepton problem of anomaly mediated supersymmetry breaking using abelian D-terms. We demonstrate that the most general extra U(1) symmetry that does not disrupt gauge coupling unification has a large set of possible charges that solves the problem. It is shown that previous studies in this direction that added both an extra hypercharge D-term and another D-term induced by B-L symmetry (or similar) can be mapped into a single D-term of the general ancillary U(1)_a. The U(1)_a formalism enables identifying the sign of squark mass corrections which leads to an upper bound of the entire superpartner spectrum given knowledge of just one superpartner mass.Comment: 10 pages, 2 figures, [v2] reference added, [v3] Eq. (9) corrected, results unaffected, [v4] version to be published in Phys. Rev. D, expanded parameter space for figures to match tex

Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

Crystalline silica (cSiO2) is a widely recognized environmental trigger of autoimmune disease. In the lupus-prone female NZBWF1 mouse, airway exposure to cSiO2 triggers pulmonary ectopic lymphoid neogenesis, systemic autoantibody elevation, and glomerulonephritis. Here we tested the hypothesis that upregulation of adaptive immune function genes in the lung precedes cSiO2-triggering of autoimmune disease in this model. The study include three groups of mice, as follows: (1) necropsied 1 d after a single intranasal instillation of 1 mg cSiO2 or vehicle, (2) necropsied 1 d after four weekly single instillations of 1 mg cSiO2 or vehicle, or (3) necropsied 1, 5, 9, or 13 weeks after four weekly single instillations of 1 mg cSiO2 or vehicle. NanoString nCounter analysis revealed modest transcriptional changes associated with innate and adaptive immune response as early as 1 d after a single cSiO2 instillation. These responses were greatly expanded after four weekly cSiO2 instillations. Concurrent with ectopic lymphoid neogenesis, dramatic increases in mRNAs associated with chemokine release, cytokine production, sustained interferon activity, complement activation, and adhesion molecules were observed. As disease progressed, expression of these genes persisted and was further amplified. Consistent with autoimmune pathogenesis, the time between 5 and 9 weeks post-instillation reflected an important transition period where considerable immune gene upregulation in the lung was observed. Upon termination of the chronic study (13 weeks), cSiO2-induced changes in transcriptome signatures were similarly robust in kidney as compared to the lung, but more modest in spleen. Transcriptomic signatures in lung and kidney were indicative of infiltration and/or expansion of neutrophils, macrophages, dendritic cells, B cells, and T cells that corresponded with accelerated autoimmune pathogenesis. Taken together, airway exposure to cSiO2 elicited aberrant mRNA signatures for both innate and adaptive immunity that were consistent with establishment of the lung as the central autoimmune nexus for launching systemic autoimmunity and ultimately, kidney injury

Structural inheritance and border fault reactivation during active early-stage rifting along the Thyolo fault, Malawi

We present new insights on the geometry, initiation and growth of the Thyolo fault, an 85 km long active border fault in the southern Malawi Rift, from high-resolution topography, field and microstructural observations. The Thyolo fault is located towards the edge of the Proterozoic Unango Terrane, and is the border fault of the Lower Shire Graben, which has experienced four phases of extension since the Jurassic. Recent activity is demonstrated by an 18.6 ± 7.7 m high fault scarp, with two substantial reductions in scarp height along strike. However, the segment boundaries suggested by these displacement measurements do not coincide with changes in fault strike. Elsewhere, a ∼5 km long fault perpendicular scarp joins two overlapping sections, yet the scarp height in this linking section is similar to the bounding sections, and there is no evidence of significant pre-linkage strain accumulation. Microstructural analyses along the fault show a 15–45 m thick footwall damage zone with a 0.7 m thick core. We suggest that favourably-oriented, pre-existing shallow structures control changes in surface geometry and the narrow fault core, whereas exploitation of weak ductile zones at depth, possibly associated with the terrane boundary, control the displacement profile of the fault

Board governance and management series: What is a healthy board?

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