Update of MRST parton distributions.

We discuss the latest update of the MRST parton distributions in response to the most recent data. We discuss the areas where there are hints of difficulties in the global fit, and compare to some other updated sets of parton distributions, particularly CTEQ6. We briefly discuss the issue of uncertainties associated with partons

MRST global fit update.

We discuss the impact of the most recent data on the MRST global analysis - in particular the new high-ET jet data and their implications for the gluon and the new small x structure function data. In the light of these new data we also consider the uncertainty in predictions for physical quantities depending on parton distributions, concentrating on the W cross-section at hadron colliders

Intelligence-Led Policing: Comparing National Approaches to its Regulation and Control

Intelligence-led policing (ILP) strategies are significant elements in modern policing arrangements. For some, policing’s enthusiasm for ILP is emblematic of ‘surveillance society’ and its attendant iniquities. Others argue that even though some of the strategies commonly associated with the term may be unpalatable; the need for ILP simply is a pragmatic reality. It is a necessary evil justified by the increasing dangerousness of the social world. Policymakers’ enthusiasm for alternative models indicates an international transformation of public policing. Such significant change gives rise to a number of questions. Not least, in this new policing paradigm: do normative checks and balances provide sufficient protection for citizens’ rights; to what extent does this reconfiguration threaten the legitimacy of public policing; and, finally, should there be cross-jurisdictional harmonization of ILP-related law and regulation

Police intelligence practice in the UK

This submission is based on evidence derived from three empirical studies of police intelligence practice carried out over the last 10 years (see James, 2013, 2016 and 2017). Those studies suggest that even if the amelioration of some long-standing problems in that milieu can be discerned, structural and cultural barriers to the effectiveness of the work remain. Too often in mainstream policing, intelligence practice is seen as ancillary to the business of ‘real’ policing; co-existing in parallel with the operational world but not routinely influencing it in sufficiently meaningful ways. In the last three years, meaningful efforts have been made to professionalise the intelligence function but the extent to which those efforts have yet borne fruit is debatable. Beyond the higher policing units (whose raison d’être is the conversion of intelligence into action against serious and organised crime), there seems to be limited understanding of the value of intelligence and a propensity to underestimate the merits of the work. Within the institution, advocates of intelligence, and motivated intelligence practitioners, have found it difficult to shift the dialectic to one in which intelligence is seen as central to the success of the policing mission. These factors undermine the institution’s ability to respond effectively both to evolving demands and changing patterns of crime

Europol's crime analysis system - practical determinants of its success

Threats to modern nation states from organised crime and terrorism create environments in which intelligence becomes a vital component of policing and security plans but the increasing use of personal data for law enforcement purposes can alter the normative relationships between stakeholders and law enforcement agencies and between agencies and citizens. For that reason, police intelligence practice demands critical examination. This paper presents a narrative inquiry, based on the authors’ experiential knowledge and empirical research, into Europol’s Crime Analysis System (ECAS). The study explains Europol’s efforts to develop data collection and analysis systems that meet the needs of EU Member States. Through ECAS, it has created powerful tools intended to deliver intelligence products that help Member States identify, localise and neutralize transnational threats to a degree not witnessed before in Europe. Nevertheless, Europol’s performance in this context seems sub-optimal. Shortcomings largely are attributed to a lack of trust between Europol and Member States leading to failures to share information between themselves and with the institution. The result is that the latter’s strategic intelligence products sometimes are deficient or incomplete. That should be of concern to stakeholders because Europol’s strategic intelligence efforts may be rendered ineffective. Shortcomings in Europol’s intelligence products also are significant for citizens because they may mean that the information-sharing process is less transparent and less accountable than citizens have a right to expect

Nonadherence to primary prophylaxis against Pneumocystis jirovecii pneumonia.

BackgroundDespite the effectiveness of prophylaxis, Pneumocystis jirovecii pneumonia (PCP) continues to be the most common serious opportunistic infection among HIV-infected persons. We describe factors associated with nonadherence to primary PCP prophylaxis.Methodology/principal findingsWe used 2000-2004 data from the Supplement to HIV/AIDS Surveillance (SHAS) project, a cross-sectional interview project of HIV-infected persons >or=18 years conducted in 18 states. We limited the analysis to persons who denied having prior PCP, reported having a current prescription to prevent PCP, and answered the question "In the past 30 days, how often were you able to take the PCP medication(s) exactly the way your doctor told you to take them?" We used multivariable logistic regression to describe factors associated with nonadherence. Of 1,666 subjects prescribed PCP prophylaxis, 305 (18.3%) were nonadherent. Persons were more likely to be nonadherent if they reported using marijuana (adjusted odds ratio [aOR] = 1.6, 95% confidence interval [CI] = 1.1-2.4), non-injection drugs other than marijuana (aOR = 1.5, 95% CI = 1.0-2.1), or injection drugs (aOR = 2.3, 95% CI = 1.3-4.1) in the past year; their mental health was "not good" for >or=1 day during the past month (aOR = 1.6, 95% CI = 1.2-2.2); their most recent CD4 count was <200 cells/microL (aOR = 1.6, 95% CI = 1.1-2.2); or taking ART usually (aOR = 9.6, 95% CI = 6.7-13.7) or sometimes/rarely/never (aOR = 18.4, 95% CI = 11.1-30.4), compared with always, as prescribed.Conclusion/significanceProviders should inquire about and promote strategies to improve adherence to PCP prophylaxis, particularly among persons who use illicit drugs, have mental health issues, and who are not compliant with ART to reduce the occurrence of PCP

Single institution implementation of permanent 131Cs interstitial brachytherapy for previously irradiated patients with resectable recurrent head and neck carcinoma

Purpose: Permanent interstitial brachytherapy is an appealing treatment modality for patients with locoregional recurrent, resectable head and neck carcinoma (HNC), having previously received radiation. Cesium-131 (131Cs) is a permanent implant brachytherapy isotope, with a low average photon energy of 30 keV and a short half-life of 9.7 days. Exposure to medical staff and family members is low; patient isolation and patient room shielding are not required. This work presents a single institution’s implementation process of utilizing an intraoperative, permanent 131Cs implant for patients with completely resected recurrent HNC. Materials & Methods: Fifteen patients receiving 131Cs permanent seed brachytherapy were included in this analysis. The process of pre-planning, selecting the dose prescription, seed ordering, intraoperative procedures, post-implant planning, and radiation safety protocols are described. Results: Tumor volumes were contoured on the available preoperative PET/CT scans and a pre-implant treatment plan was created using uniform source strength and uniform 1 cm seed spacing. Implants were performed intraoperatively, following tumor resection. In five of the fifteen cases, intraoperative findings necessitated a change from the planned number of seeds and recalculation of the pre-implant plan. The average prescription dose was 56.1 ±6.6 Gy (range, 40-60 Gy). The average seed strength used was 2.2 ±0.2 U (3.5 ±0.3 mCi). Patients returned to a recovery room on a standard surgical floor and remained inpatients, without radiation safety restrictions, based on standard surgical recovery protocols. A post-implant treatment plan was generated based on immediate post-operative CT imaging to verify the seed distribution and confirm delivery of the prescription dose. Patients were provided educational information regarding radiation safety recommendations. Conclusions: Cesium-131 interstitial brachytherapy is feasible and does not pose major radiation safety concerns; it should be considered as a treatment option for previously irradiated patients with recurrent, resectable HNC

What works in intelligence

This report analyses police intelligence practice in Britain through the lens of the ‘what works?’ concept. It is based on a survey of a self-selected group of intelligence staff together with interviews with a random sample of their number. Participants reflected on: their skills and abilities; their training; their successes and their failures; and the utility of the structures and processes within which they operated. We found that respondents broadly agreed on what contributed to effective practice. For example, analysts, intelligence officers and managers ranked a skilled workforce as of greatest import. Human intelligence (HUMINT); operational teams, capable of responding quickly to intelligence; information technology; and plentiful sources of intelligence in their communities, were consistently ranked the top four significant factors in their successes. At the same time, we conclude that while the ‘what works?’ approach has some value when applied to policing, there are clear limits to its explanatory power. We conclude that the ‘what works?’ approach also raises important, albeit largely ignored, questions about institutional memory and identity and that institutional and cultural factors represent significant barriers to the adoption of evidence-based practice in policing