Buckling of plates and plate girders subjected to patch load

The determination of the elastic critical load (buckling load) is an important element of the assessment of the ultimate load of plate girders. An analysis of the critical load of a plate corresponding to the web of an I-girder for different boundary conditions and the critical load of the I-girder itself is given in the paper. Conclusions regarding their correspondence are given. Also, experimentally determined ultimate loads of I-girders are compared with values according to Eurocode for the models used in this analysis

Primena ibuprofena u suzbijanju postoperacionog bola u stomatologiji

Postoperative pain is common complication after daily dental care. Non-steroidal anti-inflammatory drugs are among most widely prescribed analgesics for management of postoperative pain. The analgesic effect of a non-steroidal antiinflammatory drug (NSAID) is related to its ability to inhibit prostaglandin synthesis. Ibuprofen (2-proprionic acid derivate) was discovered in the 1960s as a representative of NSAIDs. It is a peripherally acting analgesic with a potent anti-inflammatory action. An extensive retrospective analysis of randomized clinical trials conducted over the last 40 years demonstrated that ibuprofen is effective in moderate to severe postoperative pain for different indications in dentistry. In comparison to other NSAIDs, ibuprofen is characterized by its efficiency, safety and good tolerance. The aim of this article was to present the most important pharmacological and therapeutic characteristics and side effects of ibuprofen used for postoperative pain treatment in dentistry.Bol koji se javi nakon hirurške intervencije je vrlo česta komplikacija u svakodnevnoj stomatološkoj praksi. U suzbijanju (lečenju) postoperacionog bola najčešće se prepisuju nesteroidni antiinflamatorni lekovi (NSAIL). Njihov analgetski efekat se zasniva, pre svega, na sprečavanju sinteze prostaglandina. Ibuprofen (derivat 2-propionske kiseline) je predstavnik velike grupe NSAIL, a otkriven je 1960. godine. Ovaj analgetik deluje na periferne nervne završetke s izrazitim protivupalnim efektom. Opsežna retrospektivna analiza randomiziranih kliničkih istraživanja u proteklih 40 godina pokazala je da je ibuprofen efikasan u suzbijanju umerenog i izraženog postoperacionog bola kod različitih indikacija. Osim efikasnosti, ibuprofen se odlikuje dobrom podnošljivošću i sigurnošću u poređenju sa drugim NSAIL. Cilj ovog rada bio je da se ukaže na najznačajnije farmakološke i terapeutske odlike, kao i neželjena dejstva ibuprofena u lečenju postoperacionog bola pri različitim indikacijama u stomatologiji

Subtypes and Mechanisms of Hypertrophic Cardiomyopathy Proposed by Machine Learning Algorithms

Hypertrophic cardiomyopathy (HCM) is a relatively common inherited cardiac disease that results in left ventricular hypertrophy. Machine learning uses algorithms to study patterns in data and develop models able to make predictions. The aim of this study is to identify HCM subtypes and examine the mechanisms of HCM using machine learning algorithms. Clinical and laboratory findings of 143 adult patients with a confirmed diagnosis of nonobstructive HCM are analyzed; HCM subtypes are determined by clustering, while the presence of different HCM features is predicted in classification machine learning tasks. Four clusters are determined as the optimal number of clusters for this dataset. Models that can predict the presence of particular HCM features from other genotypic and phenotypic information are generated, and subsets of features sufficient to predict the presence of other features of HCM are determined. This research proposes four subtypes of HCM assessed by machine learning algorithms and based on the overall phenotypic expression of the participants of the study. The identified subsets of features sufficient to determine the presence of particular HCM aspects could provide deeper insights into the mechanisms of HCM

Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups

Objective: To analyze radiographic predictors for lower third molar eruption among subjects with different anteroposterior skeletal relations and of different age groups. Materials and Methods: In total, 300 lower third molars were recorded on diagnostic digital orthopantomograms (DPTs) and lateral cephalograms (LCs). The radiographs were grouped according to sagittal intermaxillary angle (ANB), subject age, and level of lower third molar eruption. The DPT was used to analyze retromolar space, mesiodistal crown width, space/width ratio, third and second molar angulation (alpha, gamma), third molar inclination (beta), and gonion angle. The LC was used to determine ANB, angles of maxillar and mandibular prognathism (SNA, SNB), mandibular plane angle (SN/MP), and mandibular lengths. A logistic regression model was created using the statistically significant predictors. Results: The logistic regression analysis revealed a statistically significant impact of 6 angle and distance between gonion and gnathion (Go-On) on the level of lower third molar eruption (P lt .001 and P lt .015, respectively). The retromolar space was significantly increased in the adult subgroup for all skeletal classes. The lower third molar impaction rate was significantly higher in the adult subgroup with the Class II (62.3%) compared with Class III subjects (31.7%; P lt .013). Conclusion: The most favorable values of linear and angular predictors of mandibular third molar eruption were measured in Class III subjects. For valid estimation of mandibular third molar eruption, certain linear and angular measures (beta angle, Go-On), as well as the size of the retromolar space, need to be considered

Computational bioengineering for heart disease

In silico clinical trials are a new paradigm for development of a new drug and medical device. SILICOFCM project is multiscale modeling of familial cardiomyopathy which considers a comprehensive list of patient specific features as genetic, biological, pharmacologic, clinical, imaging and cellular aspects. The 3D deformable-body represents the left and right ventricle of the heart. Blood flow is modeled during the filling phase by applying the fluid-solid interaction method. The ventricle wall is modeled by 3D brick 8-node solid elements, with fibers that have threedimensional direction. The Navier-Stokes equations are solved using the ALE formulation for fluid with large displacements of the boundary. The ventricle wall model is simulated by the muscle material model. Muscle fiber orientation is defined by direction vector in 3D prescribed through input data. The outlet blood pressure is used as the boundary condition. At the same time, the wall muscle fibers are activated according to the activation function taken from specific patient measurements. Computational Platform for Multiscale Modelling in biomedical engineering is results of SGABU project that is served as an educational tool for students and researchers. The platform integrates already developed solutions and various datasets related to cancer, cardiovascular, bone disorders and tissue engineering into one multiscale platform. This will enable further validation and parameterization of models, creation of environment for future trends, e.g. in silico clinical trials, virtual surgery, development of prediction models. InSilc project is devoted to in silico mechanical stent testing within ISO 25539 standards and in silico stent deployment for metallic and biodegradable material. In-silico projects will connect basic experimental research with clinical study and bioinformatics, data mining and image processing tools using very advanced computer models for drug, stent and patient database in order to reduce animal and clinical studies.Book of abstract: 4th Belgrade Bioinformatics Conference, June 19-23, 202

Elastična kritična sila ploča i limenih nosača pod dejstvom lokalizovanog opterećenja

The determination of the elastic critical load (buckling load) is an important element of the assessment of the ultimate load of plate girders according to Eurocode 3 for design of steel structures. An analysis of the critical load of a plate corresponding to the web of an I-girder for different boundary conditions and the critical load of the I-girder itself subjected to patch load is given in the paper. Conclusions regarding their correspondence are given. Also, experimentally determined ultimate loads of I-girders are compared with predictive values according to Eurocode 3 for the models used in this analysis. A modified procedure for the ultimate load determination is proposed by following the Eurocode 3 algorithm and changing only buckling coefficient. In order to improve the ultimate load prediction, it is suggested to calculate the buckling coefficient also as a function of patch load length.Određivanje elastične kritične sile (sile izbočavanja) predstavlja važan element u određivanju granične nosivosti limenih nosača prema Evrokodu 3 za proračun čeličnih konstrukcija. U radu se daje analiza kritične sile izbočavanja izolovane ploče koja odgovara rebru Inosača s variranim uslovima oslanjanja i kritične sile koja odgovara samom I-nosaču, usled dejstva lokalizovanog opterećenja. Dati su zaključci o njihovoj vezi. Takođe, upoređena su eksperimentalno određena granična opterećenja I-nosača s vrednostima prema Evrokodu 3, za modele korišćene u ovoj analizi. Predložena je izmenjena procedura za određivanje granične nosivosti, koja sledi algoritam dat u Evrokodu 3, a prema kojoj se modifikuje izraz za određivanje koeficijenta izbočavanja. Kako bi se poboljšalo određivanje granične nosivosti, predloženo je računanje koeficijenata izbočavanja i u funkciji dužine lokalizovanog opterećenja

THE IMPORTANCE OF PSYCHODYNAMIC APPROACH DURING COVID-19 PANDEMIC

The coronavirus (COVID-19) outbreak was labeled a global pandemic by the WHO in March of 2020. Understanding how crisis influence an individual’s reactions to stressful events (and vice versa) is important in order to create meaningful and effective interventions. Our literature search have revealed lack of the papers related to psychodynamic approach to recent crisis. Psychodynamic places a large emphasis on defense mechanisms and unconscious mind, where upsetting feelings, urges, and thoughts that are too painful for us to directly look at are housed. Even though these painful feelings and thoughts are outside of our awareness, they still influence our behavior in many ways. Optimal application of psychodynamic approach offers the frame for acceptance of psychological stress in a more positive way and benefits psychological growth. We believe that including psychodynamic approach in the national public and mental health emergency system will empower Croatia and the world during (and after) COVID-19 pandemic crisis

Popliteal artery injury following traumatic knee joint dislocation in a 14-year-old boy: A case report and review of the literature

Introduction. Posterior knee joint dislocation associated with injury of the popliteal artery in children is an extremely rare condition. Rapid diagnosis and treatment are essential for limb salvage and function. Case report. We reported a 14-year-old boy who suffered traumatic displacement of the right knee and contusion of the popliteal artery during motorcycle accident. The diagnosis was confirmed using Doppler and duplex ultrasonography and digital substraction transfemoral arteriography. The urgent surgical procedure was performed using posterior approach to the popliteal artery. During the surgical exploration, rupture of the posterior cruciate ligament associated with thrombosed popliteal artery have been found. The damaged popliteal artery was resected and replaced with autologous saphenous vein graft. The last stage of the procedure was a transosseous femoral fixation of posterior circuate ligament. A 3-year-follow-up after the surgery demonstrated intact arterial perfusion and very good function of the knee with a minimal difference as compared with the contralateral knee. Conclusion. Combined orthopedic and vascular injuries are very rare in children. They require combined treatment. [Projekat Ministarstva nauke Republike Srbije, br. 175008

DOES PERSONALITY PLAY A RELEVANT ROLE IN THE PLACEBO EFFECT?

Subjective factors influencing placebo response have been a focus of numerous theoretical conceptualizations and empirical research. One such factor, individual\u27s personality, has been linked to different clinical conditions, their expressions and treatment outcomes. Thus, there is little surprise many researchers have tried to identify placebo-prone personality over the years. Because of certain methodological and conceptual issues of the earlier studies, these efforts have not been very fruitful. However, recent scientific endeavours, facilitated by improved experimental designs and neuroimaging technology, have \u27reignited the old fires\u27. It is now suggested that studies exploring the placebo-related personality traits, such as optimism/pessimism, neuroticism, and novelty seeking, need to take into account situational variables (e.g., positive or negative expectations, patient-clinician relationship) and relevant underlying neurobiological mechanisms (e.g., endogenous opioid and dopaminergic systems). Even though many questions still remain to be answered, such as the identification of different situational variables interacting with personality traits, exploration and better understanding of placebo-related personality would facilitate the use of placebo in clinical practice and improve the methodology of clinical trials