4,626 research outputs found
Diagnostic stability among chronic patients with functional psychoses: an epidemiological and clinical study
<p>Abstract</p> <p>Background</p> <p>Diagnostic stability and illness course of chronic non-organic psychoses are complex phenomena and only few risk factors or predictors are known that can be used reliably. This study investigates the diagnostic stability during the entire course of illness in patients with non-organic psychoses and attempts to identify non-psychopathological risk factors or predictors.</p> <p>Method</p> <p>100 patients with functional psychosis were initially characterised using the Operational Criteria Checklist for Psychotic Illness and Affective Illness (OPCRIT), medical records and health registers. To study the stability of diagnoses (i.e. shifts per time), we used registry data to define four measures of diagnostic variation that were subsequently examined in relation to four possible measures of time (i.e. observation periods or hospitalisation events). Afterwards, we identified putative co-variables and predictors of the best measures of diagnostic stability.</p> <p>Results</p> <p>All four measures of diagnostic variation are very strongly associated with numbers-of-hospitalisations and less so with duration-of-illness, duration-of-hospitalisation and with year-of-first-admission. The four measures of diagnostic variation corrected for numbers-of-hospitalisations were therefore used to study the diagnostic stability. Conventional predictors of illness course – e.g. age-of-onset and premorbid-functioning – are not significantly associated with stability. Only somatic-comorbidity is significantly associated with two measures of stability, while family-history-of-psychiatric-illness and global-assessment-of-functioning (GAF) scale score show a trend. However, the traditional variables age-of-first-admission, civil-status, first-diagnosis-being-schizophrenia and somatic-comorbidity are able to explain two-fifth of the variation in numbers-of-hospitalisations.</p> <p>Conclusion</p> <p>Diagnostic stability is closely linked with the contact between patient and the healthcare system. This could very likely be due to fluctuation of disease manifestation over time or presence of co-morbid psychiatric illness in combination with rigid diagnostic criteria that are unable to capture the multiple psychopathologies of the functional psychoses that results in differential diagnoses and therefore diagnostic instability. Not surprisingly, somatic-comorbidity was found to be a predictor of diagnostic variation thereby being a non-psychiatric confounder.</p
Technical Note: Mesocosm approach to quantify dissolved inorganic carbon percolation fluxes
Dissolved inorganic carbon (DIC) fluxes across the vadose zone are
influenced by a complex interplay of biological, chemical and physical
factors. A novel soil mesocosm system was evaluated as a tool for providing
information on the mechanisms behind DIC percolation to the groundwater from
unplanted soil. Carbon dioxide partial pressure (<i>p</i>CO<sub>2</sub>), alkalinity, soil
moisture and temperature were measured with depth and time, and DIC in the
percolate was quantified using a sodium hydroxide trap. Results showed good
reproducibility between two replicate mesocosms. The <i>p</i>CO<sub>2</sub> varied between
0.2 and 1.1%, and the alkalinity was 0.1–0.6 meq L<sup>−1</sup>. The measured cumulative
effluent DIC flux over the 78-day experimental period was 185–196 mg L<sup>−1</sup> m<sup>−2</sup> and in the same range as estimates derived from
<i>p</i>CO<sub>2</sub> and alkalinity in samples extracted from the side of the mesocosm
column and the drainage flux. Our results indicate that the mesocosm system
is a promising tool for studying DIC percolation fluxes and other
biogeochemical transport processes in unsaturated environments
Dexamethasone inhibits IL-9 production by human T cells
BACKGROUND: Interleukin 9 (IL-9) is produced by activated CD4+ T cells. Its effects include stimulation of mucus production, enhanced mast cell proliferation, enhanced eosinophil function, and IgE production. These effects are consistent with a role in allergic diseases. Glucocorticoids have potent anti-inflammatory effects, including suppression of cytokine synthesis, and are widely used in the treatment of allergic conditions. METHODS: We examined the effect of the glucocorticoid dexamethasone (Dex) on IL-9 mRNA expression and protein secretion with real-time RT-PCR and ELISA. Peripheral blood mononuclear cells (PBMC) were prepared from human volunteers and activated with OKT3. CD4+ T cells were purified from PBMC and activated with OKT3 plus PMA. RESULTS: IL-9 mRNA abundance and protein secretion were both markedly reduced following treatment of activated PBMC with Dex. mRNA levels were reduced to 0.7% of control values and protein secretion was reduced to 2.8% of controls. In CD4+ T cells, Dex reduced protein secretion to a similar extent. The IC(50 )value of Dex on mRNA expression was 4 nM. CONCLUSION: These results indicate that IL-9 production is very markedly inhibited by Dex. The findings raise the possibility that the beneficial effects of glucocorticoids in the treatment of allergic diseases are in part mediated by inhibition of IL-9 production
Body Topography Parcellates Human Sensory and Motor Cortex
The cytoarchitectonic map as proposed by Brodmann currently dominates models of human sensorimotor cortical structure, function, and plasticity. According to this model, primary motor cortex, area 4, and primary somatosensory cortex, area 3b, are homogenous areas, with the major division lying between the two. Accumulating empirical and theoretical evidence, however, has begun to question the validity of the Brodmann map for various cortical areas. Here, we combined in vivo cortical myelin mapping with functional connectivity analyses and topographic mapping techniques to reassess the validity of the Brodmann map in human primary sensorimotor cortex. We provide empirical evidence that area 4 and area 3b are not homogenous, but are subdivided into distinct cortical fields, each representing a major body part (the hand and the face). Myelin reductions at the hand-face borders are cortical layer-specific, and coincide with intrinsic functional connectivity borders as defined using large-scale resting state analyses. Our data extend the Brodmann model in human sensorimotor cortex and suggest that body parts are an important organizing principle, similar to the distinction between sensory and motor processing
Laudatores Temporis Acti, or Why Cosmology is Alive and Well - A Reply to Disney
A recent criticism of cosmological methodology and achievements by Disney
(2000) is assessed. Some historical and epistemological fallacies in the said
article have been highlighted. It is shown that---both empirically and
epistemologically---modern cosmology lies on sounder foundations than it is
portrayed. A brief historical account demonstrates that this form of
unsatisfaction with cosmology has had a long tradition, and rather meagre
results in the course of the XX century.Comment: 11 pages, no figures; a criticism of astro-ph/0009020; Gen. Rel.
Grav., accepted for publicatio
Intermediate Wakimoto modules for Affine sl(n+1)
We construct certain boson type realizations of affine sl(n+1) that depend on
a parameter r. When r=0 we get a Fock space realization of Imaginary Verma
modules appearing in the work of the first author and when r=n they are the
Wakimoto modules described in the work of Feigin and Frenkel
Emergence of Order in Textured Patterns
A characterization of textured patterns, referred to as the disorder function
\bar\delta(\beta), is used to study properties of patterns generated in the
Swift-Hohenberg equation (SHE). It is shown to be an intensive,
configuration-independent measure. The evolution of random initial states under
the SHE exhibits two stages of relaxation. The initial phase, where local
striped domains emerge from a noisy background, is quantified by a power law
decay \bar\delta(\beta) \sim t^{-{1/2} \beta}. Beyond a sharp transition a
slower power law decay of \bar\delta(\beta), which corresponds to the
coarsening of striped domains, is observed. The transition between the phases
advances as the system is driven further from the onset of patterns, and
suitable scaling of time and \bar\delta(\beta) leads to the collapse of
distinct curves. The decay of during the initial phase
remains unchanged when nonvariational terms are added to the underlying
equations, suggesting the possibility of observing it in experimental systems.
In contrast, the rate of relaxation during domain coarsening increases with the
coefficient of the nonvariational term.Comment: 9 Pages, 8 Postscript Figures, 3 gif Figure
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