Rol educativo del profesional de enfermería hacia los familiares de pacientes esquizofrénicos

The core aim of the study was to determine the role of nurses’ education towards the families of schizophrenic patients at the Psychiatric Hospital. Maracaibo, Venezuela. Period: September 2009 - February 2010. The design was cross-sectional, with a target population of 30 families, who answered a questionnaire of 20 items. The analysis and interpretation of the data was based on descriptive statistics. Results: In relation to the health promotion dimension, more than half the nursing staff informed them about mental illness suffered by their relatives. A high percentage of the population studied stated that informative billboards, distributed at the hospital, did not provide information on the latest scientific advances in the field of psychiatry. In addition, more than half of the population reported that during the visits, nurses did not give them scientific information about the importance of recognizing symptoms of mental illness. Also, they expressed that the nursing staff explained to them about drug treatment and their effects, but they did not give them diet recommendations. More than half of the relatives stated that nursing staff did not inform them about patients’ rights and duties. Regarding the psychosocial dimension, respondents said that nursing staff did not notify them about the health of their patients and they did not help them to express their fears or manifestations of support through physical contact nor did they show concern or interest in their patients’ problems. However, there was a high frequency of responses stating that nursing staff did allow free expression of their feelings and provided information about medical procedures and specific measures of healthcare. They were satisfied with the healthcare provided by nurses. In relation to spiritual needs, the relatives said that the nursing staff showed respect for their religious beliefs. Finally, a high percentage of people expressed that nurses respected their beliefs and customs.El objetivo fue determinar el rol educativo del profesional de enfermería hacia los familiares de pacientes esquizofrénicos recluidos en el Hospital Psiquiátrico. Maracaibo, Venezuela. Septiembre 2009- Febrero 2010. El estudio fue descriptivo, con diseño transversal, con una población de 30 familiares, a quienes se les aplicó un cuestionario de 20 ítems. El análisis e interpretación de los resultados se realizó con base a la Estadística Descriptiva.En relación a la dimensión Promoción de la Salud, se determinó, según la opinión de los familiares, que más de la mitad del personal de enfermería le ha informado sobre la enfermedad mental que padece su familiar; un alto porcentaje de la población estudiada manifestó que las carteleras que se encuentran distribuidas en el ambulatorio no ofrecen información sobre los últimos adelantos científicos en el campo de la psiquiatría; asimismo, más de la mitad de la población afirmó que durante el tiempo que permaneció de visita, el personal de enfermería no le ofreció información científica relacionada con la importancia de reconocer los síntomas de la enfermedad mental de su familiar y expresaron además que este personal sí les informó sobre el tratamiento farmacológico y los efectos que ellos producen; pero no les explicó sobre la dieta alimentaria, más de la mitad de los familiares manifestaron que el personal de enfermería no les informó sobre sus deberes y derechos.En cuanto a la dimensión Psicosocial, los familiares encuestados afirmaron que el personal de enfermería no expresó preocupación por el estado de salud de su familiar, ni les ayudó a expresar sus temores; tampoco proporcionó manifestaciones de apoyo a través del contacto físico, no demostró preocupación ni interés a sus problemas familiares. Sin embargo, se destacó la alta frecuencia de respuestas positivas en cuanto a que el personal de enfermería sí les permitió la libre expresión de sus sentimientos, se presentó por su nombre, les informó sobre los procedimientos médicos que se les realizan a su familiar, si respetan su condición social, sí ofreció información sobre los cuidados en pro de la salud de su familiar, se sienten satisfechos por la atención que recibe su familiar.En relación a la dimensión Necesidades Espirituales, los familiares afirmaron que el personal de enfermería sí respeta sus creencias religiosas.Y, por último, en un alto porcentaje, expresaron que este personal respeta sus creencias y costumbres culturales

Spag16, an Axonemal Central Apparatus Gene, Encodes a Male Germ Cell Nuclear Speckle Protein that Regulates SPAG16 mRNA Expression

Spag16 is the murine orthologue of Chlamydomonas reinhardtii PF20, a protein known to be essential to the structure and function of the “9+2” axoneme. In Chlamydomonas, the PF20 gene encodes a single protein present in the central pair of the axoneme. Loss of PF20 prevents central pair assembly/integrity and results in flagellar paralysis. Here we demonstrate that the murine Spag16 gene encodes two proteins: 71 kDa SPAG16L, which is found in all murine cells with motile cilia or flagella, and 35 kDa SPAG16S, representing the C terminus of SPAG16L, which is expressed only in male germ cells, and is predominantly found in specific regions within the nucleus that also contain SC35, a known marker of nuclear speckles enriched in pre-mRNA splicing factors. SPAG16S expression precedes expression of SPAG16L. Mice homozygous for a knockout of SPAG16L alone are infertile, but show no abnormalities in spermatogenesis. Mice chimeric for a mutation deleting the transcripts for both SPAG16L and SPAG16S have a profound defect in spermatogenesis. We show here that transduction of SPAG16S into cultured dispersed mouse male germ cells and BEAS-2B human bronchial epithelial cells increases SPAG16L expression, but has no effect on the expression of several other axoneme components. We also demonstrate that the Spag16L promoter shows increased activity in the presence of SPAG16S. The distinct nuclear localization of SPAG16S and its ability to modulate Spag16L mRNA expression suggest that SPAG16S plays an important role in the gene expression machinery of male germ cells. This is a unique example of a highly conserved axonemal protein gene that encodes two protein products with different functions

Prevalence and clinical outcomes of dystrophin-associated dilated cardiomyopathy without severe skeletal myopathy

Aims: Dilated cardiomyopathy (DCM) associated with dystrophin gene (DMD) mutations in individuals with mild or absent skeletal myopathy is often indistinguishable from other DCM forms. We sought to describe the phenotype and prognosis of DMD associated DCM in DMD mutation carriers without severe skeletal myopathy. Methods and results: At 26 European centres, we retrospectively collected clinical characteristics and outcomes of 223 DMD mutation carriers (83% male, 33 ± 15 years). A total of 112 individuals (52%) had DCM at first evaluation [n = 85; left ventricular ejection fraction (LVEF) 34 ± 11.2%] or developed DCM (n = 27; LVEF 41.3 ± 7.5%) after a median follow-up of 96 months (interquartile range 5–311 months). DCM penetrance was 45% in carriers older than 40 years. DCM appeared earlier in males and was independent of the type of mutation, presence of skeletal myopathy, or elevated serum creatine kinase levels. Major adverse cardiac events (MACE) occurred in 22% individuals with DCM, 18% developed end-stage heart failure and 9% sudden cardiac death or equivalent. Skeletal myopathy was not associated with survival free of MACE in patients with DCM. Decreased LVEF and increased left ventricular end-diastolic diameter at baseline were associated with MACE. Individuals without DCM had favourable prognosis without MACE or death during follow-up. Conclusions: DMD-associated DCM without severe skeletal myopathy is characterized by incomplete penetrance but high risk of MACE, including progression to end-stage heart failure and ventricular arrhythmias. DCM onset is the major determinant of prognosis with similar survival regardless of the presence of skeletal myopathy

Divalent Metal Vinylphosphonate Layered Materials: Compositional Variability, Structural Peculiarities, Dehydration Behavior, and Photoluminescent Properties

A family of M-VP (M = Ni, Co, Cd, Mn, Zn, Fe, Cu, Pb; VP = vinylphosphonate) and M-PVP (M = Co, Cd; PVP = phenylvinylphosphonate) materials have been synthesized by hydrothermal methods and characterized by FTIR, elemental analysis, and thermogravimetric analysis (TGA). Their structures were determined either by single crystal X-ray crystallography or from laboratory X-ray powder diffraction data. The crystal structure of some M-VP and M-PVP materials is two-dimensional (2D) layered, with the organic groups (vinyl or phenylvinyl) protruding into the interlamellar space. However, the Pb-VP and Cu-VP materials show dramatically different structural features. The porous, three-dimensional (3D) structure of Pb-VP contains the Pb center in a pentagonal pyramid. A Cu-VP variant of the common 2D layered structure shows a very peculiar structure. The structure of the material is 2D with the layers based upon three crystallographically distinct Cu atoms; an octahedrally coordinated Cu2+ atom, a square planar Cu2+ atom and a Cu+ atom. The latter has an unusual co-ordination environment as it is 3-coordinated to two oxygen atoms with the third bond across the double bond of the vinyl group. Metal-coordinated water loss was studied by TGA and thermodiffractometry. The rehydration of the anhydrous phases to give the initial phase takes place rapidly for Cd-PVP but it takes several days for Co-PVP. The M-VP materials exhibit variable dehydration-rehydration behavior, with most of them losing crystallinity during the process.Proyecto nacional MAT2010-15175 (MICINN, España

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients. The ICalmR has enrolled 140 subjects (median age 10.8 years [interquartile range 5-19]), 97 index cases and 43 family members. CALM-LQTS and CALM-CPVT are the prevalent phenotypes. Primary neurological manifestations, unrelated to post-anoxic sequelae, manifested in 20 patients. Calmodulinopathy remains associated with a high arrhythmic event rate (symptomatic patients, n = 103, 74%). However, compared with the original 2019 cohort, there was a reduced frequency and severity of all cardiac events (61% vs. 85%; P = .001) and sudden death (9% vs. 27%; P = .008). Data on therapy do not allow definitive recommendations. Cardiac structural abnormalities, either cardiomyopathy or congenital heart defects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurred. The number of familial cases and of families with strikingly different phenotypes is increasing. CONCLUSION: Calmodulinopathy has pleiotropic presentations, from channelopathy to syndromic forms. Clinical severity ranges from the early onset of life-threatening arrhythmias to the absence of symptoms, and the percentage of milder and familial forms is increasing. There are no hard data to guide therapy, and current management includes pharmacological and surgical antiadrenergic interventions with sodium channel blockers often accompanied by an implantable cardioverter-defibrillator

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry.

AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients. The ICalmR has enrolled 140 subjects (median age 10.8 years [interquartile range 5-19]), 97 index cases and 43 family members. CALM-LQTS and CALM-CPVT are the prevalent phenotypes. Primary neurological manifestations, unrelated to post-anoxic sequelae, manifested in 20 patients. Calmodulinopathy remains associated with a high arrhythmic event rate (symptomatic patients, n = 103, 74%). However, compared with the original 2019 cohort, there was a reduced frequency and severity of all cardiac events (61% vs. 85%; P = .001) and sudden death (9% vs. 27%; P = .008). Data on therapy do not allow definitive recommendations. Cardiac structural abnormalities, either cardiomyopathy or congenital heart defects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurred. The number of familial cases and of families with strikingly different phenotypes is increasing. CONCLUSION: Calmodulinopathy has pleiotropic presentations, from channelopathy to syndromic forms. Clinical severity ranges from the early onset of life-threatening arrhythmias to the absence of symptoms, and the percentage of milder and familial forms is increasing. There are no hard data to guide therapy, and current management includes pharmacological and surgical antiadrenergic interventions with sodium channel blockers often accompanied by an implantable cardioverter-defibrillator

Educational Role of Nursing towards relatives of schizophrenic patients

El objetivo fue determinar el rol educativo del profesional de enfermería hacia los familiares de pacientes esquizofrénicos recluidos en el Hospital Psiquiátrico. Maracaibo, Venezuela. Septiembre 2009- Febrero 2010. El estudio fue descriptivo, con diseño transversal, con una población de 30 familiares, a quienes se les aplicó un cuestionario de 20 ítems. El análisis e interpretación de los resultados se realizó con base a la Estadística Descriptiva. En relación a la dimensión Promoción de la Salud, se determinó, según la opinión de los familiares, que más de la mitad del personal de enfermería le ha informado sobre la enfermedad mental que padece su familiar; un alto porcentaje de la población estudiada manifestó que las carteleras que se encuentran distribuidas en el ambulatorio no ofrecen información sobre los últimos adelantos científicos en el campo de la psiquiatría; asimismo, más de la mitad de la población afirmó que durante el tiempo que permaneció de visita, el personal de enfermería no le ofreció información científica relacionada con la importancia de reconocer los síntomas de la enfermedad mental de su familiar y expresaron además que este personal sí les informó sobre el tratamiento farmacológico y los efectos que ellos producen; pero no les explicó sobre la dieta alimentaria, más de la mitad de los familiares manifestaron que el personal de enfermería no les informó sobre sus deberes y derechos. En cuanto a la dimensión Psicosocial, los familiares encuestados afirmaron que el personal de enfermería no expresó preocupación por el estado de salud de su familiar, ni les ayudó a expresar sus temores; tampoco proporcionó manifestaciones de apoyo a través del contacto físico, no demostró preocupación ni interés a sus problemas familiares. Sin embargo, se destacó la alta frecuencia de respuestas positivas en cuanto a que el personal de enfermería sí les permitió la libre expresión de sus sentimientos, se presentó por su nombre, les informó sobre los procedimientos médicos que se les realizan a su familiar, si respetan su condición social, sí ofreció información sobre los cuidados en pro de la salud de su familiar, se sienten satisfechos por la atención que recibe su familiar. Enfermería Global Nº 24 Octubre 2011 Página 95 En relación a la dimensión Necesidades Espirituales, los familiares afirmaron que el personal de enfermería sí respeta sus creencias religiosas. Y, por último, en un alto porcentaje, expresaron que este personal respeta sus creencias y costumbres culturales.ABSTRACT The core aim of the study was to determine the role of nurses’ education towards the families of schizophrenic patients at the Psychiatric Hospital. Maracaibo, Venezuela. Period: September 2009 - February 2010. The design was cross-sectional, with a target population of 30 families, who answered a questionnaire of 20 items. The analysis and interpretation of the data was based on descriptive statistics. Results: In relation to the health promotion dimension, more than half the nursing staff informed them about mental illness suffered by their relatives. A high percentage of the population studied stated that informative billboards, distributed at the hospital, did not provide information on the latest scientific advances in the field of psychiatry. In addition, more than half of the population reported that during the visits, nurses did not give them scientific information about the importance of recognizing symptoms of mental illness. Also, they expressed that the nursing staff explained to them about drug treatment and their effects, but they did not give them diet recommendations. More than half of the relatives stated that nursing staff did not inform them about patients’ rights and duties. Regarding the psychosocial dimension, respondents said that nursing staff did not notify them about the health of their patients and they did not help them to express their fears or manifestations of support through physical contact nor did they show concern or interest in their patients’ problems. However, there was a high frequency of responses stating that nursing staff did allow free expression of their feelings and provided information about medical procedures and specific measures of healthcare. They were satisfied with the healthcare provided by nurses. In relation to spiritual needs, the relatives said that the nursing staff showed respect for their religious beliefs. Finally, a high percentage of people expressed that nurses respected their beliefs and customs

Impact of cognitive-behavioral treatment on quality of life in panic disorder patients.

Panic disorder (PD) is associated with significant social and health consequences. The present study examined the impact of treatment on PD patients ' quality of life. Patients ( N = 156) meeting DSM—III—R ( Diagnostic and Statistical Manual of Mental Disorders [3rd ed., rev.]; American Psychiatric Association, 1987) criteria for PD with agoraphobia were randomly assigned to group cognitive—behavioral treatment (CBT) or a delayed-treatment control. An assessment battery measuring the major clinical features of PD as well as quality of life was administered at baseline (Week 0), posttreatment (Week 9) and 6-month follow-up (Week 35). Consistent with previous studies, PD patients displayed significant impairment in quality of life at intake. Compared with delayed-treatment control participants, CBT-treated participants showed significant reductions in impairment that were maintained at follow-up. Consistent with prediction, anxiety and phobic avoidance were significantly associated with quality of life, whereas frequency of panic attacks was not. Portions of this article were presented at the 27th Annual Convention of the Association for Advancement o