Percorsi adriatici. Mobilità studentesca e dinamiche sociali tra le universitates della Puglia, Padova e Venezia (XV-XVI secolo)

Questa ricerca si concentra sulla mobilit\ue0 di studenti che, muovendo dai territori della Puglia storica tra il XV e il XVI secolo, scelsero lo Studio di Padova come sede privilegiata per la propria formazione accademica, facendo tappa anche presso quelli di Ferrara e Bologna. Tale fenomeno si inscrive nel quadro di secolari e costanti rapporti politici, commerciali e culturali lungo l\u2019area adriatica. L\u2019incrocio della variegata documentazione rintracciata - documentazione di carattere universitario, registri di notai, raccolte documentarie come i Codici Diplomatici e i Libri Rossi, Cronache locali - unita alla bibliografia sul tema, ha fatto emergere una vasta gamma di notizie, che sono state analizzate e sviluppate nel corso dei capitoli. La prima parte della ricerca costituisce una presentazione del caso di studio, delle questioni storiografiche che sono alla base, delle metodologie adottate. La seconda parte prende in esame i contesti sociali e culturali di provenienza degli studenti, i luoghi e le modalit\ue0 della formazione in patria e quelli della successiva formazione universitaria. La terza parte si concentra esclusivamente sugli attori di questa particolare forma di mobilit\ue0: si ricostruiscono le estrazioni sociali, i casi di tradizioni familiari di studi, le reti di relazioni costruite, le carriere intraprese con il titolo di dottore. La quarta ed ultima parte si concretizza in un catalogo di studenti e dottori pugliesi, dove sono raccolte tutte le notizie di carattere biografico rintracciate. La ricerca si conclude con una appendice documentaria e con l\u2019elenco delle fonti e la bibliografia.This research concentrate on student mobility from Apulian cities during the XV and the XVI century, in particular towards Padua\u2019s Studium, but also towards Ferrara and Bologna. This phenomenon belongs in the secular and political, economic, cultural relationships in the Adriatic area. Sources utilized \u2013 universitary documentation, notarial acts, Codici Diplomatici and Libri Rossi, local chronicles \u2013 and bibliography, are important for informations analised during the research. The first part is a presentation of the case-study, historiographical questions and methodologies. The second part analise social and cultural context of students and their local and universitary studies. The third part is concentrated on students: their social origin, family traditions of studies, social relationships, careers. The fourth part is a catalogue of Apulian students and doctors, with biographical informations. The last part contained documentation and the list of sources and the bibliography

Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog

Abstract Background An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis and perineuritis in a dog with chronic otitis, bilateral tympanokeratomas and presumed extension of otic infection to the central nervous system. Case presentation An 11-year-old intact male Dalmatian dog with chronic bilateral otitis externa and sudden development of symptoms of vestibular disease was examined. Due to the dog’s old age the owner opted for euthanasia without any further examination or treatment and the dog was submitted for necropsy. Transection of the ears revealed grey soft material in the external ear canals and pearly white, dry material consistent with keratin in the tympanic bullae bilaterally. The brain and meninges were grossly unremarkable. Microscopical findings included bilateral otitis externa and media, unilateral otitis interna, ganglioneuritis and perineuritis of the spiral ganglion of the vestibulocochlear nerve and multifocal to coalescing, purulent meningitis. A keratinizing squamous epithelial layer continuous with the external acoustic meatus lined the middle ear compartments, consistent with bilateral tympanokeratomas. Focal bony erosion of the petrous portion of the temporal bone and squamous epithelium and Gram-positive bacterial cocci were evident in the left cochlea. The findings suggest that meningitis developed secondary to erosion of the temporal bone and ganglioneuritis and/or perineuritis of the vestibulocochlear nerve. Conclusions Middle ear tympanokeratoma is an important and potentially life-threatening otic condition in the dog. Once a tympanokeratoma has developed expansion of the cyst can lead to erosion of bone and extension of otic infection to the inner ear, vestibulocochlear ganglion and nerve potentially leading to bacterial infection of the central nervous system

MOESM1 of Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog

Additional file 1. Photomicrograph demonstrating neuronal inclusions. Eosinophilic, round to oval intracytoplasmic inclusions were found in neurons of the thalamus. Haematoxylin and eosin stain, bar: 5 Οm