226 research outputs found
Comparative study between Conventional Adenoid Curettage and Endoscopic Assisted Adenoid Curettage
Adenoidectomy is a common procedure done for various causes like chronic adenoiditis or chronic adenotonsillitis or adenoid hypertrophy with middle ear and sinus disorders. Clinical features includes rhinorrhea, chronic mouth
breathing, excessive snoring, apneic episodes, enuresis, daytime somnolence, neurocognitive and learning problems. Adenoidectomy provides a symptomatic recovery with improvement in the quality of life and health status of the
patients. In this study we discussed on COMPARATIVE STUDY BETWEEN CONVENTIONAL ADENOID CURETTAGE AND ENDOSCOPIC
ASSISTED ADENOID CURETTAGE. The results we obtained suggested that the endoscopic assisted adenoid curettage is comparatively better in the post operative tissue remnant, Eustachian tube injury, symptomatic relief
Fractional difference inequalities of Gronwall-Bellman type
Discrete inequalities, in particular the discrete analogues of the GronwallβBellman inequality, have been extensively used in the analysis of nite difference equations. The aim of the present paper is to establish some fractional difference inequalities of GronwallβBellman type which provide explicit bounds for the solutions of fractional difference equations
Short-route synthesis of (3E,5Z)-tetradecadienoic acid (megatomic acid), the sex attractant of the black carpet beetle
A new and expeditious route to (3E,5Z)-3,5-tetradecadienoic acid (megatomic acid), the sex attractant of the black carpet beetle Attagenus megatoma (Fabricius), is reported which proceeds with 97% stereoselectivity; Cadiot-Chodkiewicz cross-coupling of 1-decyne and 4-bromo-3-butyn-1-ol in the presence of CuCl, followed by stereoselective reductions and Jones oxidation, gives the target molecule, with the synthetic pheromone showing a positive electrophysiological response
Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats
Aim: To study the effect of silymarin on the levels of tumor markers and MDA (malondialdehyde) β DNA adduct formation during N-nitrosodiethylamine induced hepatocellular carcinoma in male Wistar albino rats. Methods: The levels of AFP, CEA and activities of liver marker enzymes in serum, MDA-DNA immunohistochemistry were done according to standard procedures in the control and experimental groups of rats. Results: Hepatocellular carcinoma was evidenced from significant (p < 0.05) increases of alpha-fetoprotein, carcinoembryonic antigen, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase and 5?-nucleotidase in serum and increased MDA-DNA adducts were also observed in the tissue sections of hepatocellular carcinoma. Silymarin treatment significantly attenuated the alteration of these markers and decreased the levels of MDA-DNA adduct formation. Conclusion: Silymarin could be developed as a promising chemotherapeutic adjuvant for the treatment of liver cancer.Π¦Π΅Π»Ρ: ΠΈΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΠ»ΠΈΠΌΠ°ΡΠΈΠ½Π° Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π΄Π΄ΡΠΊΡΠΎΠ²
ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π° Ρ ΠΠΠ (MDA-DNA) ΠΏΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΠΈΠ½ΠΎΠΌΡ Ρ ΠΊΡΡΡ Π»ΠΈΠ½ΠΈΠΈ ΠΈΡΡΠ°Ρ. ΠΠ΅ΡΠΎΠ΄Ρ: ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌΠΈ
Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅
ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ MDA-DNA Π² ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ
Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π°Π»ΡΡΠ°-ΡΠ΅ΡΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π°, ΡΠ°ΠΊΠΎΠ²ΠΎΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ
Π°Π½ΡΠΈΠ³Π΅Π½Π°, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°ΡΠΏΠ°ΡΡΠ°Ρ- ΠΈ Π°Π»Π°Π½ΠΈΠ½Π°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ, ΡΠ΅Π»ΠΎΡΠ½ΠΎΠΉ ΠΈ ΠΊΠΈΡΠ»ΠΎΠΉ ΡΠΎΡΡΠ°ΡΠ°Π·Ρ, Π»Π°ΠΊΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ, Π³Π°ΠΌΠΌΠ°Π³Π»ΡΡΠ°ΠΌΠΈΠ»ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ
ΠΈ 5-Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π°Π·Ρ. ΠΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠ΅
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π΄Π΄ΡΠΊΡΠΎΠ² MDA-DNA Π² ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ ΡΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΠΈΠ½ΠΎΠΌΠΎΠΉ. ΠΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠΈΠ»ΠΈΠΌΠ°ΡΠΈΠ½Π°
Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ°Π»ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π΄Π΄ΡΠΊΡΠΎΠ² MDA-DNA Π² ΡΠΊΠ°Π½ΠΈ
ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΈΠ»ΠΈΠΌΠ°ΡΠΈΠ½Π° ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ Π΄Π»Ρ ΠΏΡΠ΅Π΄ΡΠΏΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ
Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ N-Π½ΠΈΡΡΠΎΠ·ΠΎΠ΄ΠΈΡΡΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠΌ Ρ ΠΊΡΡΡ, ΠΈ ΡΡΠΎΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±Π΅ΡΠ°ΡΡΠΈΠΌ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ
Π°Π΄ΡΡΠ²Π°Π½ΡΠΎΠΌ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΊΠ° ΠΏΠ΅ΡΠ΅Π½ΠΈ
AN EVALUATION ON PRESCRIBING PATTERN OF ANTIBIOTICS IN PAEDIATRIC INPATIENTS AT TERTIARY CARE HOSPITAL
Objective: Our objective of the study was to evaluate the prescribing patterns of drugs with cost analysis in pediatric inpatients at tertiary care hospital.
Methods: It is an observational prospective study carried out in pediatric inpatients with a sample of 180 patients based on age, inclusion, and exclusion criteria for period of 3 months. The patientβs data were collected using patient case record form and analysis of the data was done.
Results: Of 180 patients data were collected, the results show that majority of gender admitted in the hospital were male children 94 (52%) and many are from age group of early childhood (2β5 years) 67 (37%). Respiratory tract infections are diagnosis most commonly analyzed and off overall 236 prescribed antibiotics cephalosporins 86 (43%) and combination of amoxicillin + clavulanic acid 25 (71%) is the class of antibiotics prescribed higher than other class of drugs. Parental 173 (73%) route of administration was observed to be followed more than other route. The percentage of cost variation of antibiotics observed in the study reveals that the huge variations were seen in the cost of medication in maximum and minimum cost.
Conclusion: The present study reveals that the prescribed antibiotics were as per the diagnosis of the patient and not by proceeding proper culture sensitivity testing. Hence, awareness about antibiotic must be created among practicing physicians to increase the therapeutic compliance of the patient
An EulerianβEulerian formulation for erosion modelling: an alternate approach.
Sand is commonly produced besides petroleum fluids and it presents a major erosional hazard leading to pipe failures. Particle erosion is a complex process in which material is removed due to the repeated particle impacts. Conventionally, a CFD flow solver and computationally intensive lagrangian particle tracking subβroutines, known as EulerianβLagrangian (EβL) model, along with empirical erosion equations are used to predict the erosion rates. The present work introduces an EulerianβEulerian (EβE) approach in which the multiphase granular model resolves the solid phase and obviates the need of particles tracking. Particleβladen turbulent flow across a flow restrictor, based on an experimental study, is chosen for validation. Numerical experiments are done in Simcenter STARβCCM+. Comparison with the experimental data demonstrate a good agreement and in particular, the EβE model yields reliable predictions of impact wear locations, erosion rates as those of EβL model. A 90Β° square bend is also simulated and comparison of erosion rates on the concave wall demonstrate that EβE model can be used as an alternate to computationally expensive approaches
Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms
Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated. Here, we show that the classical Chlamydomonas motility mutant pf23 is defective in the Chlamydomonas homolog of DYX1C1. The pf23 mutant has a 494 bp deletion in the DYX1C1 gene and expresses a shorter DYX1C1 protein in the cytoplasm. Structural analyses, using cryo-ET, reveal that pf23 axonemes lack most of the inner dynein arms. Spectral counting confirms that DYX1C1 is essential for the assembly of the majority of ciliary inner dynein arms (IDA) as well as a fraction of the outer dynein arms (ODA). A C-terminal truncation of DYX1C1 shows a reduction in a subset of these ciliary IDAs. Sucrose gradients of cytoplasmic extracts show that preassembled ciliary dyneins are reduced compared to wild-type, which suggests an important role in dynein complex stability. The role of PF23/DYX1C1 remains unknown, but we suggest that DYX1C1 could provide a scaffold for macromolecular assembly
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