Seismic-Hazard Map of Southeast Missouri and Likely Magnitude of the February 1812 New Madrid Earthquake

The New Madrid seismic zone lies beneath the upper Mississippi Embayment, straddling the border between southeastern Missouri and northwestern Tennessee. In late 1811 and early 1812, it produced five earthquakes of magnitudes \u3e6.5, violently shaking the central and eastern United States (CEUS). Its magnitude and recurrence are of concern to today\u27s central United States regions. By considering the effects of local geology, deterministic scenario maps (Mw 7.3 and 7.7) were produced for ground motions intended to simulate the 7 February 1812 event (NM3), which was the largest felt. These maps include spatial estimates of peak ground acceleration and of 0.2 s and 1.0 s spectral acceleration (SA). Compared with the isoseismic map of modified Mercalli intensities (MMIs) in southeast Missouri, the MMIs converted from 0.2 s SA suggest that Mw 7.7 is a plausible scenario for NM3. To better constrain its magnitude, other CEUS sites shaken during NM3 were also examined. Local site conditions were studied and evaluated before calculating the threshold magnitude for the reported MMIs. These results indicate that the magnitude of NM3 was at least Mw 7.6, which validates our estimated size of Mw 7.7 for southeastern Missouri

Seismic Site Classifications for the St. Louis Urban Area

Regional National Earthquake Hazards Reduction Program (NEHRP) soil class maps have become important input parameters for seismic site characterization and hazard studies. The broad range of shallow shear-wave velocity (VS30, the average shear-wave velocity in the upper 30 m) measurements in the St. Louis area results in significant uncertainties between the actual spot values and the averaged values used to assign NEHRP soil classes for regional seismic hazard studies. In the preparation of an NEHRP site classification map of the St. Louis urban area, we analyzed 92 shear-wave velocity (VS) measurements, supplemented by 1400+ standard penetration test (SPT) profiles in areas bereft of VS measurements. SPT blow counts correlated to VS values based on the published correlations. The data were then compiled for respective surficial geologic units and bedrock type. These data suggest that the reciprocal of VS30 exhibits a fairly linear relationship with depth to bedrock, likely because VS30 is a function of the thickness of surficial materials exhibiting relatively low VS values. The VS30 values were interpolated by summing the regressed VS30 on the depth to bedrock and kriged values of the regression residuals. The resulting NEHRP site classification maps predict that upland areas of the St. Louis area are spatially classified as soil site classes SB to SD, while the low-lying floodplains are consistently classified as SD to SF

Learning sources of variability from high-dimensional observational studies

Causal inference studies whether the presence of a variable influences an observed outcome. As measured by quantities such as the "average treatment effect," this paradigm is employed across numerous biological fields, from vaccine and drug development to policy interventions. Unfortunately, the majority of these methods are often limited to univariate outcomes. Our work generalizes causal estimands to outcomes with any number of dimensions or any measurable space, and formulates traditional causal estimands for nominal variables as causal discrepancy tests. We propose a simple technique for adjusting universally consistent conditional independence tests and prove that these tests are universally consistent causal discrepancy tests. Numerical experiments illustrate that our method, Causal CDcorr, leads to improvements in both finite sample validity and power when compared to existing strategies. Our methods are all open source and available at github.com/ebridge2/cdcorr

Linqits: Big data on little clients

ABSTRACT We present LINQits, a flexible hardware template that can be mapped onto programmable logic or ASICs in a heterogeneous system-on-chip for a mobile device or server. Unlike fixed-function accelerators, LINQits accelerates a domainspecific query language called LINQ. LINQits does not provide coverage for all possible applications-however, existing applications (re-)written with LINQ in mind benefit extensively from hardware acceleration. Furthermore, the LINQits framework offers a graceful and transparent migration path from software to hardware. LINQits is prototyped on a 2W heterogeneous SoC called the ZYNQ processor, which combines dual ARM A9 processors with an FPGA on a single die in 28nm silicon technology. Our physical measurements show that LINQits improves energy efficiency by 8.9 to 30.6 times and performance by 10.7 to 38.1 times compared to optimized, multithreaded C programs running on conventional ARM A9 processors

Clinical and Echocardiographic Findings of Newly Diagnosed Acute Decompensated Heart Failure in Elderly Patients

PURPOSE: Elderly patients (pts) (EPs; ≥ 65 years old) with newly diagnosed-acute decompensated heart failure (ND-ADHF) have not yet been studied. The aim of the present study was to investigate clinical characteristics, including echocardiographic findings and prognosis, for EPs with ND-ADHF and to compare those with non-elderly pts (NEPs). MATERIALS AND METHODS: We retrospectively investigated 256 pts (144 males, 63.0 ± 14.8 years old) who were admitted to our hospital between January 2005 and March 2009 with ND-ADHF. Clinical characteristics and echocardiographic parameters were analyzed in EPs (n = 135, 58 males) and NEPs (n = 121, 86 males). RESULTS: In intergroup comparison, female gender, diabetes mellitus, previous stroke and hypertension were more common in EPs. Body mass index (22.3 ± 4.5 vs. 24.0 ± 4.4 kg/m(2)), estimated glomerular filtration rate (54.8 ± 24.3 vs. 69.2 ± 30.7 mL/min/m(2)), C-reactive protein (28.5 ± 46.9 vs. 7.6 ± 11.6 mg/dL), hemoglobin (12.3 ± 2.1 vs. 13.6 ± 2.3 g/dL) and N-terminal pro-brain natriuretic peptide level (10,538.2 ± 10,942.3 vs. 6,771.0 ± 8,964.7 pg/mL) were significantly different (p < 0.05 for all). Early mitral inflow velocity to early diastolic mitral annular velocity (E/E') was significantly higher in EPs than in NEPs (21.2 ± 9.4 vs. 18.0 ± 8.9, p < 0.05). During follow-up (44.7 ± 14.5 months), there were no significant differences in in-hospital mortality, re-hospitalization and cardiovascular mortality between EPs and NEPs (p = NS for all). CONCLUSION: EPs with ND-ADHF have different clinical characteristics and higher LV filling pressure when compared with NEPs. However, the clinical outcomes for NEPs with ND-ADHF are not necessarily more favorable than those for EPs.ope

St. Louis Area Earthquake Hazards Mapping Project: Seismic and Liquefaction Hazard Maps

We present probabilistic and deterministic seismic and liquefaction hazard maps for the densely populated St. Louis metropolitan area that account for the expected effects of surficial geology on earthquake ground shaking. Hazard calculations were based on a map grid of 0.005°, or about every 500 m, and are thus higher in resolution than any earlier studies. To estimate ground motions at the surface of the model (e.g., site amplification), we used a new detailed near-surface shear-wave velocity model in a 1D equivalent- linear response analysis. When compared with the 2014 U.S. Geological Survey (USGS) National Seismic Hazard Model, which uses a uniform firm-rock-site condition, the new probabilistic seismic-hazard estimates document much more variability. Hazard levels for upland sites (consisting of bedrock and weathered bedrock overlain by loess-covered till and drift deposits), show up to twice the ground-motion values for peak ground acceleration (PGA), and similar ground-motion values for 1.0 s spectral acceleration (SA). Probabilistic ground-motion levels for lowland alluvial floodplain sites (generally the 20-40-m-thick modern Mississippi and Missouri River floodplain deposits overlying bedrock) exhibit up to twice the ground-motion levels for PGA, and up to three times the ground-motion levels for 1.0 s SA. Liquefaction probability curves were developed from available standard penetration test data assuming typical lowland and upland water table levels. A simplified liquefaction hazard map was created from the 5%-in-50-year probabilistic ground-shaking model. The liquefaction hazard ranges from low (\u3c40% of area expected to liquefy) in the uplands to severe (\u3e60% of area expected to liquefy) in the lowlands. Because many transportation routes, power and gas transmission lines, and population centers exist in or on the highly susceptible lowland alluvium, these areas in the St. Louis region are at significant potential risk from seismically induced liquefaction and associated ground deformation

The Long-Term Effect of Cancer on Incident Stroke: A Nationwide Population-Based Cohort Study in Korea

Background and Purpose: Despite the recent growing interest in the cancer–stroke association, the long-term effect, and organ-specific association with stroke incidence in subjects with cancer have not been clearly defined.Methods: Data were obtained from the Korean National Health Insurance Service National Sample Cohort database between 2002 and 2015. To investigate the effects of cancer on stroke incidence, subjects were classified into cancer and non-cancer groups based on the period after cancer diagnosis and origin organ of cancer. To minimize the effects of selection bias, we performed a propensity score matching analysis with covariates of demographic data, vascular risk factors, antithrombotics use and statin use. Incident stroke was diagnosed based on operational definition and classified into ischemic stroke and hemorrhagic stroke.Results: Data of 20,707 subjects with cancer and 675,594 without cancer were analyzed for 7 follow-up years. The subjects with cancer had higher risk of any stroke (subdistribution hazard ratio [SHR], 1.13; 95% confidence interval [CI], 1.02–1.26; p = 0.0181) than those without cancer. Similar trend was found for ischemic stroke (SHR, 1.17; 95% CI, 1.05–1.31; p = 0.0054), but not for hemorrhagic stroke. The risk of stroke was increased in subjects with cancer in the digestive organ, respiratory and intrathoracic organ, and “others (such as breast and female and male reproductive organs)” in 3 years; however, the association disappeared thereafter except those with “others” cancer. Chemotherapy increased the risk of ischemic stroke (SHR 1.21; 95% CI, 1.03–1.41).Conclusions: Cancer increases the risk of stroke at 3 years after the diagnosis of cancer, and the effect was maintained for 7 years. The association between cancer and stroke incidence depends on the organ from which the cancer originated and chemotherapy