ABO incompatibile graft management in pediatric transplantation

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor's RBCs have antigens missing on the recipient's cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.Peer reviewe

Growth gap in hyperbolic groups and amenability

International audienceWe prove a general version of the amenability conjecture in the unified setting of a Gromov hyperbolic group G acting properly cocompactly either on its Cayley graph, or on a CAT(-1)-space. Namely, for any subgroup H of G, we show that H is co-amenable in G if and only if their exponential growth rates (with respect to the prescribed action) coincide. For this, we prove a quantified, representation-theoretical version of Stadlbauer's amenability criterion for group extensions of a topologically transitive subshift of finite type, in terms of the spectral radii of the classical Ruelle transfer operator and its corresponding extension. As a consequence, we are able to show that, in our enlarged context, there is a gap between the exponential growth rate of a group with Kazhdan's property (T) and the ones of its infinite index subgroups. This also generalizes a well-known theorem of Corlette for lattices of the quaternionic hyperbolic space or the Cayley hyperbolic plane

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes