Assessment of Sustainability Governance in Higher Education Institutions - a Systemic Tool using a Governance Equalizer

The paper aims to add to the discussion on sustainability governance in higher education institutions by examining the role of sustainability assessment and introducing an assessment tool inspired by systemic thinking and centered on a ‘governance equalizer’. It discusses recent research and argues that the complexity inherent in sustainability governance remains to be addressed adequately. While a number of models and frameworks have been proposed, most of them remain caught between narrow, management-oriented approaches on the one hand, and rather abstract approaches that provide little guidance for improving the field on the other. Sustainability assessment tools represent a potential way to bridge this gap. While there are existing tools which include issues of sustainability governance, these are often limited to aspects that are easily quantifiable and neglect more complex aspects. Against this background, the article proposes an alternative tool to assess sustainability governance in higher education institutions. The tool is based on a multi-case study in Germany and has been tested in a series of workshops. Drawing on the concept of a ‘governance equalizer’, it focuses on the functional requirements of sustainability governance in five dimensions - politics, profession, organization, knowledge, and the public—and how they are addressed by the HEI. The tool raises the level of abstraction in order to capture complexity, but at the same time keeps sight of governance structures, processes, instruments, and practices. It combines clearly defined criteria that are assessed using carefully developed maturity scales with a focus on stakeholder participation and knowledge

Interdependencies of Culture and Functions of Sustainability Governance at Higher Education Institutions

Sustainable development practices in higher education institutions are diverse, with regard not only to the types of challenges that have to be addressed, but also to the forms of sustainability governance adopted by individual higher education institutions. This paper aims to reflect on the aspects of organizational culture that are particularly crucial for the implementation of sustainable practices at higher education institutions. Specifically, it addresses the research question: how do different organizational cultures affect approaches to sustainability governance at higher education institutions (HEIs)? It reflects on data from multi-case studies at eleven German higher education institutions. Four of the cases are analyzed in this paper to draw out the insights they offer on how organizational culture shapes the institutions’ approach to sustainable development. A governance equalizer is used as a functional framework for evaluating and discussing the influence of different cultural orientations on sustainability governance. In addition to providing many insights and findings in relation to specific cases, comparison of the different institutions, their governance structures and their cultures of sustainable development helps to emphasize that there is no single cultural factor that can be identified as directly promoting particular governance structures. Rather, there is an active interplay between cultural orientations, which influence, and are also influenced by, the measures deployed. Such influence is not instantly apparent but needs time to develop, and it evolves in a variety of ways as illustrated by the case studies

Coordinating vector field equations and diagrams with a serious game in introductory physics

Mathematical reasoning with algebraic and graphical representations is essential for success in physics courses. Many problems require students to fluently move between algebraic and graphical representations. We developed a freely available serious game to challenge the representational fluency of introductory students regarding vector fields. Within the game, interactive puzzles are solved using different types of vector fields that must be configured with the correct mathematical parameters. A reward system implemented in the game prevents from using trial-and-error approaches and instead encourages the player to establish a mental connection between the graphical representation of the vector field and the (algebraic) equation before taking any action. For correct solutions, the player receives points and can unlock further levels. We report about the aim of the game from an educational perspective, describe potential learning scenarios and reflect about a first attempt to use the game in the classroom

Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state

Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mTORC1 inhibitors. We aimed to evaluate cellular processes regulated by mTORC1 in TSC cells with different mutations before tumor development. Flow cytometry analyses were performed to evaluate cell viability, cell cycle and autophagy in non-tumor primary TSC cells with different heterozygous mutations and in control cells without TSC mutations, before and after treatment with rapamycin (mTORC1 inhibitor). We did not observe differences in cell viability and cell cycle between the cell groups. However, autophagy was reduced in mutated cells. After rapamycin treatment, mutated cells showed a significant increase in the autophagy process (p=0.039). We did not observe differences between cells with distinct TSC mutations. Our main finding is the alteration of autophagy in non-tumor TSC cells. Previous studies in literature found autophagy alterations in tumor TSC cells or knock-out animal models. We showed that autophagy could be an important mechanism that leads to TSC tumor formation in the haploinsufficiency state. This result could guide future studies in this field

AMNÉSIA GLOBAL TRANSITÓRIA: EPIDEMIOLOGIA, FISIOPATOLOGIA, CLÍNICA E TERAPÊUTICA

A amnésia global transitória (AGT) é um quadro súbito de amnésia glo- bal, não acompanhada de outros déficits neurológicos, com duração de duas a 24 horas e cuja recuperação se dá espontaneamente. A incidência na população geral está estimada em 5-10 casos/100.000 pessoas/ano. Diferentes mecanismos fisiopatológicos, como fatores vasculares ou epiléticos, têm sido propostos para explicar a AGT, sendo consensual que haja acometimento transitório de regiões do hipocampo e do giro para-hipocampal. Além da amnésia anterógrada acompanhada por amnésia retrógra- da, o paciente apresenta desorientação (tempo/espaço), estando pre- servadas outras habilidades cognitivas, como memória semântica e capacidades visuo-construtivas. Esses déficits tendem a remitir após 24h, sendo o prognóstico favorável na maioria dos casos. O diagnós- tico diferencial de AGT é amplo e diversas condições clínicas, como eventos cérebro-vasculares, epilepsias, infecções e intoxicações po- dem mimetizá-lo, de modo que uma investigação clínica cuidadosa é imperativa. As recorrências não são frequentes nos quadros típicos. A AGT não requer tratamento específico, mas devem ser tratados fa- tores de risco cardiovascular eventualmente identificados durante a propedêutica de AGT. O clínico deve esclarecer o paciente a respeito do caráter benigno da AGT. Estudos com seguimento longitudinal dos pacientes são necessários para maior compreensão dos mecanismos fisiopatológicos da AGT e para melhor compreensão clínica e neuro- biológica dos déficits cognitivos apresentados por esses pacientes.

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Syncranial Osteology Of Arctocephalus Gazella (Pinnipedia, Otariidae) From Rio Grande Do Sul, Brazil

Volume: 88Start Page: 51End Page: 5

Pricing a waiver of premium upon disability

Development of approaches to price a waiver of premium upon disability rider based on provision terms set forth by John Hancock Insurance and available data. Approaches involved random variables; age at disablement, duration of disability, and age at death. A rider premium was calculated such that the random loss (a function of those random variables) had an expected value of zero. Through data collection and SAS programming, an expense-loaded rider premium was calculated as a percentage of base premium