1,254 research outputs found
UNDERSTANDING CITIZEN PARTICIPATION IN GOVERNMENTAL SOCIAL MEDIA: A CASE STUDY OF THE INDONESIAN REGIONAL POLICE
Governments increasingly leverage social media to deliver better services to the public. Web 2.0 technologies enable people to interact and collaborate with one another efficiently and effectively. The use of web 2.0 technologies by government – government 2.0 – enables citizen to interact and collaborate with government in the delivery of public services. This exploratory study examines the use of social media in Indonesia. The focus is on examining the potential of social media in improving the effectiveness and efficiency of public service delivery, and how social media might boost the relationship between government and the public. We focus in particular on the use of social media by regional police action – Traffic Management Center Polda Metro Jaya in the Jakarta region which has been recognized as a social media best practice within the Indonesian government. We find that social media has contributed to information dissemination among the public. Furthermore, social media use results in improved public image and enables citizen participation in government service delivery
Does Age Matter in Mobile User Experience? Impact of Age on Relative Importance of Antecedents of Mobile User Experience
Interest in user experience (UX) has grown as both academics and practitioners perceive that focusing on functional usability provides only a limited understanding of human computer interaction. UX is a comprehensive concept that goes beyond usability and utilitarian aspects of technology use, to include the non-utilitarian, aesthetic, emotional and experiential aspects. A growing body of research based on Hassenzahl’s basic UX model has examined the impact of hedonic and pragmatic product attributes on user perceptions of beauty and goodness of the technology, and their subsequent impact on satisfaction. However, the influence of age on these relationships has largely been ignored. We conducted a survey of children, young adults and the elderly’s mobile phone UX, and conducted a multi-group analysis of the UX model. We found that age really matters in mobile phone user experience. While prior research has focused on young adults, the important determinants of UX for children and the elderly differed significantly. In accordance with the UX model, young adults’ UX evaluation was influenced by both pragmatic and hedonic qualities. Children and the elderly on the other hand focused on hedonic qualities. Our study has implications for the study and practice of UX design
Diffusion of Open Access: Why are some disciplines more successful than others?
Since the first international statement on open access – the Budapest Open Access Initiative in February 2002, a growing number of open access publishing outlets have become available, and several policies in the European Union and the U.S. have been introduced to mandate the open access archiving of publicly funded research. In spite of these strides, research practices today are still far from completely embracing the open access movement. In this research in progress, we draw on models of the diffusion of changes in institutional practices across networks in order to understand how open source practices of unrestricted access to information and ideas have spread in the academic and research disciplines – in short, the diffusion of open access models of research dissemination across disciplines
Content Versus Structure in Information Environments: A Longitudinal Analysis of Website Preferences
From the prospective traveler surfing the web for cheap vacations to executives analyzing market trends with a data warehouse, at home and at work, people are confronted with increasingly richer information environments. This study is an attempt at modeling the behavior over time of the “information consumer” (web surfer or executive) in such environments. The objective is to gain a better understanding of how to design the technologies that support and enhance the interaction with these information environments. Two key design variables for information environments are examined: content quality and structural quality. Drawing on research in human-computer interaction and ecological psychology, a behavioral model is developed in which it is postulated that the importance of structural quality will diminish with time, whereas content quality will increaseinimportance. Atwo-stagemethodologyisemployedwhichcombinesalongitudinalexperimentwith a cross-sectional survey. Both the survey and experiment are conducted in the context of informational websites. The experiment provided 178 undergraduates with repeated exposure over several weeks to eight custom-built websites, manipulated to vary in content quality and structural quality for which their preferences (and associated rationales) were elicited at three time points over the course of the experiment. Additionally, 163 of the undergraduates also completed a survey providing data about the effect of content and structure on usage behavior for sites for which they had mature experience. Preliminary results of the experimental data support the hypotheses. The research has potentially significant implications for the design of information environments
Phosphorylation of α-syntrophin is responsible for its subcellular localization and interaction with dystrophin in muscle cells
79-85Syntrophin is a well-known adaptor protein that links intracellular proteins with the dystrophin-glycoprotein complex (DGC) at the sarcolemma. However, little is known about the underlying mechanism that regulates the intracellular localization of α-syntrophin and its interaction with dystrophin. In this study, we demonstrate that α-syntrophin phosphorylation determines its intracellular localization and interaction with dystrophin in muscle cells. α-Syntrophin, a predominant isoform in skeletal muscles, directly interacts with ion channels, enzymes, receptors, and DGC proteins. Despite α-syntrophin being a potential signaling molecule, most studies focus on its function as a dystrophin-associated protein. However, we previously reported that α-syntrophin has a variety of DGC-independent functions to modulate cell migration, differentiation, survival, and protein stability. According to the results of the in vitro phosphorylation assays using subcellular fractions, the phosphorylated α-syntrophin accumulated only at the plasma membrane, and this event occurred regardless of dystrophin expression. However, the α-syntrophin interacting with dystrophin at the membrane was not in a phosphorylated state. We also identified that protein kinase C (PKC) was involved in the phosphorylation of α-syntrophin, which restricted α-syntrophin to interact with dystrophin. In conclusion, we demonstrate that the phosphorylation of α-syntrophin by PKC regulates its intracellular localization and interaction with dystrophin
Phosphorylation of α-syntrophin is responsible for its subcellular localization and interaction with dystrophin in muscle cells
Syntrophin is a well-known adaptor protein that links intracellular proteins with the dystrophin-glycoprotein complex (DGC) at the sarcolemma. However, little is known about the underlying mechanism that regulates the intracellular localization of α-syntrophin and its interaction with dystrophin. In this study, we demonstrate that α-syntrophin phosphorylation determines its intracellular localization and interaction with dystrophin in muscle cells. α-Syntrophin, a predominant isoform in skeletal muscles, directly interacts with ion channels, enzymes, receptors, and DGC proteins. Despite α-syntrophin being a potential signaling molecule, most studies focus on its function as a dystrophin-associated protein. However, we previously reported that α-syntrophin has a variety of DGC-independent functions to modulate cell migration, differentiation, survival, and protein stability. According to the results of the in vitro phosphorylation assays using subcellular fractions, the phosphorylated α-syntrophin accumulated only at the plasma membrane, and this event occurred regardless of dystrophin expression. However, the α-syntrophin interacting with dystrophin at the membrane was not in a phosphorylated state. We also identified that protein kinase C (PKC) was involved in the phosphorylation of α-syntrophin, which restricted α-syntrophin to interact with dystrophin. In conclusion, we demonstrate that the phosphorylation of α-syntrophin by PKC regulates its intracellular localization and interaction with dystrophin
Multidirectional Instability Accompanying an Inferior Labral Cyst
Paralabral cyst of the shoulder joint can be observed in 2% to 4% of the general population, particularly in men during the third and fourth decade. On average, these cysts measure 10 mm to 20 mm in diameter and are located preferentially on the postero-superior aspect of the glenoid. The MRI has increased the frequency of the diagnosis of paralabral cysts of the shoulder joint. Paralabral cysts of the shoulder joint usually develop in the proximity of the labrum. The relationship between shoulder instability and labral tears is well known, however, the association of shoulder instability with a paralabral cyst is rare. Shoulder instability may cause labral injury or labral injury may cause shoulder instability, and then injured tear develops paralabral cyst. In our patient, the inferior paralabral cyst may be associated with inferior labral tears and instability MRI
The Economics of All-You-Can-Read Pricing: Tariff Choice, Contract Renewal, and Switching for E-Book Purchases
E-book markets are currently moving through a period of disequilibrium as new pricing structures (i.e., flat-fee subscriptions) are rapidly embraced by major vendors. On the basis of a novel dataset, we investigate how the availability of “all-you-can-read” pricing programs influences consumers’ tariff choice, contract renewal, and switching behaviors. Consistent with the rational choice framework, the findings suggest that most e-book consumers significantly gain from subscription-based tariffs. However, we also find some other intriguing results. Among the three subscription designs examined, the 1-week plan affords consumers more economic benefits than do 1-day or 1-month programs. The economic gains derived from subscription-based tariffs diminish as consumers renew their subscriptions under the same contract duration. Consumers who switch to other plans also suffer from reduced savings. Finally, iOS users are more inclined to select subscription models than are Android users because of the absence of in-app purchase functionalities for the former
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