Ionosphere Variability in Low and Mid-Latitudes of India Using GPS-TEC Estimates from 2002 to 2016

Continuous Global Positioning System (cGPS) observations spanning 14 years at 24 cGPS sites located in low and mid-latitudes (5–35° N) in the Indian subcontinent are analyzed to extract the ionosphere delay from one-way residuals for each satellite. Absolute integrated electron content (IEC) is the integral of electrons per m2 along the line of sight between the satellite and receiver. Total electron content (TEC) is determined from IEC using elevation mapping function to normalize the variation of the ray path length through the ionosphere based on the GPS satellite elevation angle. In this study, GPS TEC estimates temporally cover two solar cycles (23 and 24) and spatially cover equatorial ionization anomaly (EIA) region and beyond, thus depicting the ionosphere variability in space, time and geographical location. Results capture different phases of solar cycle, EIA, annual, daily, diurnal and seasonal variability of ionosphere in northern hemisphere. This chapter gives significant insights in to the high and random variability of TEC associated with the changes in solar activity, intensity of the sun radiation, zenith angle at which they impinge the earth’s atmosphere, equatorial electrojet (EEJ) and plasma flow

Pre-seismic, co-seismic and post-seismic displacements associated with the Bhuj 2001 earthquake derived from recent and historic geodetic data

The 26th January 2001 Bhuj earthquake occurred in the Kachchh Rift Basin which has a long history of major earthquakes. Great Triangulation Survey points (GTS) were first installed in the area in 1856-60 and some of these were measured using Global Positioning System (GPS) in the months of February and July 2001. Despite uncertainties associated with repairs and possible reconstruction of points in the past century, the re-measurements reveal pre-seismic, co-seismic and post-seismic deformation related to Bhuj earthquake. More than 25 M-strain contraction north of the epicenter appears to have occurred in the past 140 years corresponding to a linear convergence rate of approximately 10 mm/yr across the Rann of Kachchh. Motion of a single point at Jamnagar 150 km south of the epicenter in the 4 years prior to the earthquake, and GTS-GPS displacements in Kathiawar suggests that pre-seismic strain south of the epicenter was small and differs insignificantly from that measured elsewhere in India. Of the 20 points measured within 150 km of the epicenter, 12 were made at existing GTS points which revealed epicentral displacements of up to 1 m, and strain changes exceeding 30 M-strain. Observed displacements are consistent with reverse co-seismic slip. Re-measurements in July 2001 of one GTS point (Hathria) and eight new points established in February reveal post-seismic deformation consistent with continued slip on the Bhuj rupture zone

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria

Global Navigation Satellite Systems for Natural Hazard Estimation

44-48Global Positioning System is now being recognized as a sensitive tool for natural disaster risk and early warning applications such as continental deformation studies, meteorology, landslide hazard mapping, glacier dynamics and volcano deformation. With the recent launch of a dedicated navigation satellite, India will also soon upgrade its GPS-based services helping track hazards more effectively. </span

Inter annual, spatial, seasonal, and diurnal variability of precipitable water vapour over northeast India using GPS time series

<p>We present multi-scale variability of GPS-derived column integrated precipitable water vapour (PWV) estimated over five continuous GPS sites of northeast India from 2004 to 2012. PWV is estimated from GPS-derived zenith total delay using observed surface pressure and temperature from collocated meteorological sensors as well as obtained by interpolating European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis project (ERA-Interim) global reanalysis dataset. PWV estimated using ERA-Interim-derived parameters compare well with the PWV estimated using observed meteorological parameters with bias of less than ± 0.1 mm and highest root mean square error of 0.56 mm. The average PWV for the study period is about 17 mm at Bomdila in the Eastern Himalayas, about 20 mm at Shillong in Shillong plateau, about 31 mm at Lumami in Arokan-Yoma Hill ranges, and about 43 mm at Guwahati and Tezpur in Assam valley. The high altitude sites show low annual PWV variability (around 49%) than the low altitude sites (around 63–67%). Seasonal PWV value coincides with the monsoon with maximum in summer and minimum in the winter. However, percentage seasonal PWV variability is found to be almost same (around 68%) for all the five sites. The Assam valley sites do not show a distinct diurnal cycle whereas the high altitude sites indicate a distinct diurnal cycle coinciding with the daily solar cycle. Insights in to GPS PWV variability and rainfall are presented for the study period.</p

Estimates of precipitable water vapour from GPS data over the Indian subcontinent

Water vapour plays a dominant role in the high-energy thermodynamics of the atmosphere, notably, the genesis of storm systems. However, its distribution is difficult to resolve by conventional means, since water vapour exhibits very high spatial and temporal variability. The growing networks of continuously operating GPS systems, however, offer the possibility of estimating the integrated water vapour (IWV) or, equivalently precipitable water vapour (PW). These estimates constitute critical inputs in operational weather forecasting and fundamental research to model atmospheric storm systems, atmospheric chemistry, and the hydrological cycle. This paper presents the results of IWV estimates from GPS data from continuously operating GPS stations established by C-MMACS at Bangalore, Kodaikanal, Hanle and Shillong over the 3-year period (2001-2003). These are the first results of such an endeavor, towards the study of PW at four different geographical locations in the Indian subcontinent

No evidence of unusually large postseismic deformation in Andaman region immediately after 2004 Sumatra-Andaman earthquake

Static offsets due to the 26 December 2004 Sumatra‐Andaman earthquake have been reported from the campaign mode GPS measurements in the Andaman‐Nicobar region. However, these measurements contain contributions from postseismic deformation that must have occurred in the 16–25 days period between the earthquake and the measurements. We analyse these and tide gauge measurements of coseismic deformation, a longer time series of postseismic deformation from GPS measurements at Port Blair in the South Andaman and aftershocks, to suggest that postseismic displacement not larger than 7 cm occurred in the 16–25 days following the earthquake in the South Andaman and probably elsewhere in the Andaman Nicobar region. Earlier, this contribution was estimated to be as large as 1 m in the Andaman region, which implied that the magnitude of the earthquake based on these campaign mode measurements should be decreased. We suggest an Mw for this earthquake as 9.23