MLB v. SLJ: Equal Justice for Indigent Parents

The United States Supreme Court recently decided that a state may not, consistent with the Due Process and Equal Protection clauses of the Fourteenth Amendment, condition appeals from trial court decrees terminating parental rights on the affected parent\u27s ability to pay record preparation fees. In M.L.B. v. S.L.J., the Supreme Court found that, just as a state may not block an indigent petty offender\u27s access to an appeal afforded others, Mississippi may not deny M.L.B., because of her poverty, appellate review of the sufficiency of the evidence on which the trial court found her unfit to remain a parent

Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry

Background: Metabolism of human chorionic gonadotropin (hCG) in the serum and kidney yields the terminal urinary product hCG ß-core fragment (hCGßcf), comprising two disulfide-linked peptides (ß6-ß40 and ß55-ß92) of which one (ß6-ß40) retains truncated N-linked sugars. Hyperglycosylated hCGßcf may indicate choriocarcinoma or Down syndrome, but the glycosylation profile of hCGßcf has not been thoroughly evaluated. Methods: hCGßcf, purified from pregnancy urine, was reduced by "on-target" dithiothreitol (DTT) reduction and analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The mass ([M+H]+) of the primary sequence of the glycosylated peptide ß6-ß40 was subtracted from the m/z values of the discrete peaks observed to give the masses of the carbohydrate moieties. Carbohydrate structure was predicted by sequentially subtracting the masses of the monosaccharide residues corresponding to N-linked carbohydrates of the hCG ß-subunit reported in the literature. Results: Mass spectra of hCGßcf revealed a broad triple peak at m/z 8700–11300. After reduction, the triple peak was replaced by a discrete set of peaks between m/z 4156 and 6354. A peak at m/z 4156.8 corresponded to the nonglycosylated peptide (ß55-ß92). The remaining nine peaks indicated that urinary hCGßcf comprises a set of glycoforms smaller and larger than the trimannosyl core. Conclusions: hCGßcf comprises a wider set of glycoforms than reported previously. Peaks of highest mass indicate evidence of hyperglycosylated carbohydrate moieties. The data support previous reports that hCGßcf oligosaccharides lack sialic acid and galactose residues. No indication was found of a ß6-ß40 peptide that was entirely devoid of carbohydrate

Serial reproduction reveals the geometry of visuospatial representations

An essential function of the human visual system is to locate objects in space and navigate the environment. Due to limited resources, the visual system achieves this by combining imperfect sensory information with a belief state about locations in a scene, resulting in systematic distortions and biases. These biases can be captured by a Bayesian model in which internal beliefs are expressed in a prior probability distribution over locations in a scene. We introduce a paradigm that enables us to measure these priors by iterating a simple memory task where the response of one participant becomes the stimulus for the next. This approach reveals an unprecedented richness and level of detail in these priors, suggesting a different way to think about biases in spatial memory. A prior distribution on locations in a visual scene can reflect the selective allocation of coding resources to different visual regions during encoding (“efficient encoding”). This selective allocation predicts that locations in the scene will be encoded with variable precision, in contrast to previous work that has assumed fixed encoding precision regardless of location. We demonstrate that perceptual biases covary with variations in discrimination accuracy, a finding that is aligned with simulations of our efficient encoding model but not the traditional fixed encoding view. This work demonstrates the promise of using nonparametric data-driven approaches that combine crowdsourcing with the careful curation of information transmission within social networks to reveal the hidden structure of shared visual representations

The Circumstellar Extinction of Planetary Nebulae

We analyze the dependence of circumstellar extinction on core mass for the brightest planetary nebulae (PNe) in the Magellanic Clouds and M31. We show that in all three galaxies, a statistically significant correlation exists between the two quantities, such that high core mass objects have greater extinction. We model this behavior, and show that the relation is a simple consequence of the greater mass loss and faster evolution times of high mass stars. The relation is important because it provides a natural explanation for the invariance of the [O III] 5007 planetary nebula luminosity function (PNLF) with population age: bright Population I PNe are extinguished below the cutoff of the PNLF. It also explains the counter-intuitive observation that intrinsically luminous Population I PNe often appear fainter than PNe from older, low-mass progenitors.Comment: 12 pages, 2 figures, accepted for ApJ, April 10, 199

Optical Detection of Two Intermediate Mass Binary Pulsar Companions

We report the detection of probable optical counterparts for two Intermediate Mass Binary Pulsar (IMBP) systems, PSR J1528-3146 and PSR J1757-5322. Recent radio pulsar surveys have uncovered a handful of these systems with putative massive white dwarf companions, thought to have an evolutionary history different from that of the more numerous class of Low Mass Binary Pulsars (LMBPs) with He white dwarf companions. The study of IMBP companions via optical observations offers us several new diagnostics: the evolution of main sequence stars near the white-dwarf-neutron star boundary, the physics of white dwarfs close to the Chandrasekhar limit, and insights into the recycling process by which old pulsars are spun up to high rotation frequencies. We were unsuccessful in our attempt to detect optical counterparts of PSR J1141-6545, PSR J1157-5112, PSR J1435-6100, and PSR J1454-5846.Comment: 9 pages, 2 figures, accepted for publication in ApJ

Fraudulent Tax Refunds: The Notorious Career of Harriette Walters

Harriette Walters embezzled more than $48 million from the District of Columbia by processing fraudulent real estate tax refunds. This paper describes the Walters scheme and discusses, from the perspective of the COSO framework, internal control weaknesses that enabled the fraud to go undetected for more than 20 years. While this analysis of the Walters fraud should be of interest to both accounting academics and audit professionals, it should be particularly helpful to students, fi nancial managers, and inexperienced auditors in understanding the importance of effective internal controls for preventing and detecting fraud in a wide variety of organizational settings