5,015 research outputs found
Primary Klebsiella pneumoniae Liver Abscess with Metastatic Spread to Lung and Eye, a North-European Case Report of an Emerging Syndrome
A syndrome of community acquired liver abscess caused by highly virulent hypermucoviscous, rmpA positive Klebsiella pneumoniae strains occurs with high incidence in Asia. We here report a case complicated by metastatic infection, to our knowledge, the first one described in Northern Europe. This and other recently reported cases indicate the emergence of this severe syndrome outside of Asia
Effectiveness of a minimal resource fracture liaison service
Purpose The purpose of this study was to investigate if a 2-year intervention with a minimal resource fracture liaison service (FLS) was associated with increased investigation and medical treatment and if treatment was related to reduced re-fracture risk. Methods The FLS started in 2013 using existing secretaries (without an FLS coordinator) at the emergency department and orthopaedic wards to identify risk patients. All patients older than 50 years of age with a fractured hip, vertebra, shoulder, wrist or pelvis were followed during 2013–2014 (n = 2713) and compared with their historic counterparts in 2011–2012 (n = 2616) at the same hospital. Re-fractures were X-ray verified. A time-dependent adjusted (for age, sex, previous fracture, index fracture type, prevalent treatment, comorbidity and secondary osteoporosis) Cox model was used. Results The minimal resource FLS increased the proportion of DXA-investigated patients after fracture from 7.6 to 39.6 % (p < 0.001) and the treatment rate after fracture from 12.6 to 31.8 %, which is well in line with FLS types using the conventional coordinator model. Treated patients had a 51 % lower risk of any re-fracture than untreated patients (HR 0.49, 95 % CI 0.37–0.65 p < 0.001). Conclusions We found that our minimal resource FLS was effective in increasing investigation and treatment, in line with conventional coordinator-based services, and that treated patients had a 51 % reduced risk of new fractures, indicating that also non-coordinator based fracture liaison services can improve secondary prevention of fractures
Biopsy findings in giant cell arteritis: relationship to baseline factors and corticosteroid treatment.
Effects of hydrogen bonding on supercooled liquid dynamics and the implications for supercooled water
The supercooled state of bulk water is largely hidden by unavoidable
crystallization, which creates an experimentally inaccessible temperature
regime - a 'no man's land'. We address this and circumvent the crystallization
problem by systematically studying the supercooled dynamics of hydrogen bonded
oligomeric liquids (glycols), where water corresponds to the chain-ends alone.
This novel approach permits a 'dilution of water' by altering the hydrogen bond
concentration via variations in chain length. We observe a dynamic crossover in
the temperature dependence of the structural relaxation time for all glycols,
consistent with the common behavior of most supercooled liquids. We find that
the crossover becomes more pronounced for increasing hydrogen bond
concentrations, which leads to the prediction of a marked dynamic transition
for water within 'no man's land' at T~220 K. Interestingly, the predicted
transition thus takes place at a temperature where a so called 'strong-fragile'
transition has previously been suggested. Our results, however, imply that the
dynamic transition of supercooled water is analogous to that commonly observed
in supercooled liquids. Moreover, we find support also for the existence of a
secondary relaxation of water with behavior analogous to that of the secondary
relaxation observed for the glycols.Comment: 20 pages, 5 figures; corrected typos, title changed, small clarifying
text changes, two labels removed from Fig. 2
PMS78 Quality of Life in Patients With Axial Spondyloarthritis in Clinical Practice In Sweden: Baseline Results From A Longitudinal Study
Shotgun Phage Display - Selection for Bacterial Receptins or other Exported Proteins
Shotgun phage display cloning involves construction of libraries from randomly fragmented bacterial chromosomal DNA, cloned genes, or eukaryotic cDNAs, into a phagemid vector. The library obtained consists of phages expressing polypeptides corresponding to all genes encoded by the organism, or overlapping peptides derived from the cloned gene. From such a library, polypeptides with affinity for another molecule can be isolated by affinity selection, panning. The technique can be used to identify bacterial receptins and identification of their minimal binding domain, and but also to identify epitopes recognised by antibodies. In addition, after modification of the phagemid vector, the technique has also been used to identify bacterial extracytoplasmic proteins
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