The effects of matter density uncertainties on neutrino oscillations in the Earth

We compare three different methods to evaluate uncertainties in the Earth's matter density profile, which are relevant to long baseline experiments, such as neutrino factories.Comment: 3 pages, 1 figure. Talk given at the NuFact'02 Workshop, London, 1-6 July, 200

The LHCb Timing and Fast Control system

In this paper we describe the LHCb Timing and Fast Control (TFC) system. It is different from that of the other LHC experiments in that it has to support two levels of high-rate triggers. Furthermore, emphasis has been put on partitioning and on locating the TFC mastership in one type of module: the Readout Supervisor. The Readout Supervisor handles all timing, trigger, and control command distribution. It generates auto-triggers as well as controls the trigger rates. Partitioning is handled by a programmable patch panel/switch introduced in the TTC distribution network between a pool of Readout Supervisors and the Front-End electronics. I

The BIM-based Integrated Design of the SHiP Project Decay Volume

The Search for Hidden Particles (SHiP) experiment is a new general-purpose fixed target facility proposed at the CERN Super Proton Synchrotron accelerator to search for longlived exotic particles associated with Hidden Sectors and Dark Matter. This paper reports on the BIM integrated design of SHiP’s decay volume, a conical steel vessel under vacuum that should host several large particle physics detector systems. The use of BIM characterized the design of the decay volume, both in the modeling and structural design phase, and in the process definition phase for the realization and implementation in the facility of the device. This procedure helps to minimize the risks of incorrect design and construction of the device during the whole process. With the automation of the virtual model and the use of interoperable software, in addition to speeding up the exchange of information, it is possible also to export the detailed information of the structural design directly to the numerical control machines for the prefabrication of the various steel modules. Then, the BIM approach to support the integrated design of the SHiP project decay volume from the conceptual planning to the construction phase is shown in this work

Neurobiological insight into hyperbaric hyperoxia

Aim: Hyperbaric hyperoxia (HBO) is known to modulate aerobic metabolism, vasoreactivity and blood flow in the brain. Nevertheless, mechanisms underlying its therapeutic effects, especially in traumatic brain injury (TBI) and stroke patients, are debated. The present study aimed at investigating regional cerebral blood flow (rCBF) distribution during acute HBO exposure. Methods: Regional cerebral blood flow response was investigated in seven healthy subjects exposed to either normobaric normoxia or HBO with ambient pressure/inspired oxygen pressure of 101/21 and 250/250 kPa respectively. After 40 min at the desired pressure, they were injected a perfusion tracer and subsequently underwent brain single photon emission computed tomography. rCBF distribution changes in the whole brain were assessed by Statistical Parametric Mapping. Results: During HBO, an increased relative rCBF distribution was found in sensory-motor, premotor, visual and posterior cingulate cortices as well as in superior frontal gyrus, middle/inferior temporal and angular gyrus and cerebellum, mainly in the dominant hemisphere. During normobaric normoxia, a higher 99mTc-HMPAO distribution in the right insula and subcortical structures as well as in bilateral hippocampi and anterior cingulated cortex was found. Conclusions: The present study firstly confirmed the rCBF distribution increase during HBO in sensory-motor and visual cortices, and it showed for the first time a higher perfusion tracer distribution in areas encompassed in dorsal attention system and in default mode network. These findings unfold both the externally directed cognition performance improvement related to the HBO and the internally directed cognition states during resting-state conditions, suggesting possible beneficial effects in TBI and stroke patients

All-Digital Massive MIMO Uplink and Downlink Rates under a Fronthaul Constraint

We characterize the rate achievable in a bidirectional quasi-static link where several user equipments communicate with a massive multiple-input multiple-output base station (BS). In the considered setup, the BS operates in full-digital mode, the physical size of the antenna array is limited, and there exists a rate constraint on the fronthaul interface connecting the (possibly remote) radio head to the digital baseband processing unit. Our analysis enables us to determine the optimal resolution of the analog-to-digital and digital-to-analog converters as well as the optimal number of active antenna elements to be used in order to maximize the transmission rate on the bidirectional link, for a given constraint on the outage probability and on the fronthaul rate. We investigate both the case in which perfect channel-state information is available, and the case in which channel-state information is acquired through pilot transmission, and is, hence, imperfect. For the second case, we present a novel rate expression that relies on the generalized mutual-information framework.Comment: 5 pages, 5 figure

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.

Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins. The immunomodulatory role of SPMs in adaptive immune cells is of interest. We report that D-series resolvins (resolvin D1 and resolvin D2) and maresin 1 modulate adaptive immune responses in human peripheral blood lymphocytes. These lipid mediators reduce cytokine production by activated CD8(+) T cells and CD4(+) T helper 1 (TH1) and TH17 cells but do not modulate T cell inhibitory receptors or abrogate their capacity to proliferate. Moreover, these SPMs prevented naïve CD4(+) T cell differentiation into TH1 and TH17 by down-regulating their signature transcription factors, T-bet and Rorc, in a mechanism mediated by the GPR32 and ALX/FPR2 receptors; they concomitantly enhanced de novo generation and function of Foxp3(+) regulatory T (Treg) cells via the GPR32 receptor. These results were also supported in vivo in a mouse deficient for DHA synthesis (Elovl2(-/-)) that showed an increase in TH1/TH17 cells and a decrease in Treg cells compared to wild-type mice. Additionally, either DHA supplementation in Elovl2(-/-) mice or in vivo administration of resolvin D1 significantly reduced cytokine production upon specific stimulation of T cells. These findings demonstrate actions of specific SPMs on adaptive immunity and provide a new avenue for SPM-based approaches to modulate chronic inflammation.This work was supported by Fondazione Italiana Sclerosi Multipla (FISM) to V.C. (grant 2015/R/8) and in part by National Institutes of Health (P01095467 and GM38765) to C.N.S, by Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN grant 2010–2011) to M.M., and by Ministero della Salute (RF-2011- 02346771) and FISM (grant 2013/R/2) to L.B