Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin.

Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses. Skin is frequently exposed to the DNA damaging effects of UV irradiation, a known etiology in skin cancer. Thus, understanding the defense mechanisms in response to UV, including the role of SIRTs and PARPs, may be important in developing skin cancer prevention strategies. Here, we report expression of the seven SIRT family members in human skin. SIRTs gene expressions are progressively upregulated in A431 epidermoid carcinoma cells (SIRTs1 and 3), actinic keratoses (SIRTs 2, 3, 5, 6, and 7) and squamous cell carcinoma (SIRTs 1-7). Photodamage induces dynamic changes in SIRT expression with upregulation of both SIRT1 and SIRT4 mRNAs. Specific losses of SIRT proteins occur early after photodamage followed by accumulation later, especially for SIRT4. Niacin restriction, which decreases NAD(+), the sirtuin substrate, results in an increase in acetylated proteins, upregulation of SIRTs 2 and 4, increased inherent DNA damage, alterations in SIRT responses to photodamage, abrogation of PARP activation following photodamage, and increased sensitivity to photodamage that is completely reversed by repleting niacin. These data support the hypothesis that SIRTs and PARPs play important roles in resistance to photodamage and identify specific SIRTs that respond to photodamage and may be targets for skin cancer prevention

Thermionic research and development program Final report, 15 Jul. 1966 - 15 Jan. 1968

Thermionic research and development program - improvement of performance of low emitter temperature cesium vapor thermionic converter

Comment on “Does the Hydrated Electron Occupy a Cavity?” [Science 329, 65, (2010)]

Exact quantum mechanical calculations examining a recently implemented pseudopotential show that the results reported by Larsen et al. are based on a model that contains inaccuracies. We illustrate that, in contrast to the model used, the true electron-water interaction is repulsive in the region relevant to the reported extended electron distribution, consistent with the cavity model. The reported simulated properties of the hydrated electron are shown to be very sensitive to this problem

Passenger ride quality determined from commercial airline flights

The University of Virginia ride-quality research program is reviewed. Data from two flight programs, involving seven types of aircraft, are considered in detail. An apparatus for measuring physical variations in the flight environment and recording the subjective reactions of test subjects is described. Models are presented for predicting the comfort response of test subjects from the physical data, and predicting the overall comfort reaction of test subjects from their moment by moment responses. The correspondence of mean passenger comfort judgments and test subject response is shown. Finally, the models of comfort response based on data from the 5-point and 7-point comfort scales are shown to correspond

Application of ride quality technology to predict ride satisfaction for commuter-type aircraft

A method was developed to predict passenger satisfaction with the ride environment of a transportation vehicle. This method, a general approach, was applied to a commuter-type aircraft for illustrative purposes. The effect of terrain, altitude and seat location were examined. The method predicts the variation in passengers satisfied for any set of flight conditions. In addition several noncommuter aircraft were analyzed for comparison and other uses of the model described. The method has advantages for design, evaluation, and operating decisions

On the orientational ordering of long rods on a lattice

We argue that a system of straight rigid rods of length k on square lattice with only hard-core interactions shows two phase transitions as a function of density, rho, for k >= 7. The system undergoes a phase transition from the low-density disordered phase to a nematic phase as rho is increased from 0, at rho = rho_c1, and then again undergoes a reentrant phase transition from the nematic phase to a disordered phase at rho = rho_c2 < 1.Comment: epl.cl

Burner rig corrosion of SiC at 1000 deg C

Sintered alpha-SiC was examined in both oxidation and hot corrosion with a burner rig at 400 kPa (4 atm) and 1000 C with a flow velocity of 310 ft/sec. Oxidation tests for times to 46 hr produced virtually no attack, whereas tests with 4 ppm Na produced extensive corrosion in 13-1/2 hr. Thick glassy layers composed primarily of sodium silicate formed in the salt corrosion tests. This corrosion attack caused severe pitting of the silicon carbide substrate which led to a 32 percent strength decrease below the as-received material. Parallel furnace tests of Na2SO4/air induced attacked yielded basically similar results with some slight product composition differences. The differences are explained in terms of the continuous sulfate deposition which occurs in a burner rig

Transportation systems evaluation methodology development and applications, phase 3

Transportation systems or proposed changes in current systems are evaluated. Four principal evaluation criteria are incorporated in the process, operating performance characteristics as viewed by potential users, decisions based on the perceived impacts of the system, estimating what is required to reduce the system to practice; and predicting the ability of the concept to attract financial support. A series of matrix multiplications in which the various matrices represent evaluations in a logical sequence of the various discrete steps in a management decision process is used. One or more alternatives are compared with the current situation, and the result provides a numerical rating which determines the desirability of each alternative relative to the norm and to each other. The steps in the decision process are isolated so that contributions of each to the final result are readily analyzed. The ability to protect against bias on the part of the evaluators, and the fact that system parameters which are basically qualitative in nature can be easily included are advantageous

With the Iowa State Home Economics Association

Home Economics in relation to the American Home is the keynote of the program of the Iowa State Home Economics Association, whose annual meeting will be held in Des Moines on November 5 and 6